Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Vladimir, Snirc"'
Autor:
Milan Nagy, Ladislav Šoltés, Katarína Valachová, Lubica Surovcikova-Machova, Maria Banasova, Elena Priesolova, Ivo Juránek, Vladimir Snirc
Publikováno v:
General physiology and biophysics. 31:57-64
Stobadine·2HCl and its two hydrophilic derivatives SM1dM9dM10·2HCl and SME1i- ProC2·HCl were tested in the function of antioxidants on hyaluronan (HA) degradation induced by the Weissberger oxidative system (ascorbate plus Cu(II)). As a primary me
Autor:
Svorad Štolc, Gajdosíková A, Vladimir Snirc, Zdenka Gasparova, Oľga Ondrejičková, A. Gajdosik
Publikováno v:
Interdisciplinary Toxicology. 3:122-126
Oxidative stress induced by the Fe2+/ascorbic acid system or model ischemiain vitro: effect of carvedilol and pyridoindole antioxidant SMe1EC2 in young and adult rat brain tissueNew effective strategies and new highly effective neuroprotective agents
Autor:
Milan Stefek, Çimen Karasu, Lucia Račková, Vincenzo Carbone, Ossama El-Kabbani, Vladimir Snirc, Vassilis J. Demopoulos, Djoubissie Paul-Omer, Magdalena Majekova, Zelmira Bezakova
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:4908-4920
Starting from the efficient hexahydropyridoindole antioxidant stobadine, a series of carboxymethylated tetrahydro- and hexahydropyridoindole derivatives was synthesized and tested for the inhibition of aldose reductase, an enzyme involved in the etio
Autor:
Ružena Sotníková, Želmíra Bezáková, Pavol Májek, Svorad Štolc, Magdalena Majekova, Vladimir Snirc
Publikováno v:
Open Medicine, Vol 1, Iss 4, Pp 370-378 (2006)
α1 — adrenolytic activities of pyridoindole derivatives recently synthesized in the Institute of Experimental Pharmacology, Slovak Academy of Sciences, were measured. A characteristic set of derivatives (five active, one with a threshold activity
Autor:
S. Štvrtina, Gajdosíková A, Zdenka Gasparova, Vladimir Snirc, Magdalena Majekova, Svorad Štolc
Publikováno v:
Cellular and Molecular Neurobiology. 26:1493-1502
1. The role of oxidative stress, and accordingly uncontrolled reactive oxygen species generation/action, have been widely documented in a number of different neuronal pathologies. However, the concept of pharmacological interventions in prevention an
Publikováno v:
Journal of Medicinal Chemistry. 49:2543-2548
New synthetic substituted hexahydropyridoindoles were studied for their radical scavenging ability in a system of an ethanolic solution of alpha,alpha'-diphenyl-beta-picrylhydrazyl and for their lipid peroxidation inhibitory properties in a suspensio
Publikováno v:
Redox report : communications in free radical research. 18(2)
Objectives The subject of this study was the hexahydropyridoindole compound SMe1EC2 with reported antioxidant and neuroprotective effects and low toxicity. In this study, the antioxidant action of SMe1EC2 was investigated in a greater detail in the s
Autor:
Maria Juskova, Milan Stefek, Vladimir Snirc, Ivana Milackova, Nikos Triantos, Anna Tsantili-Kakoulidou
Publikováno v:
Bioorganicmedicinal chemistry. 19(23)
Novel carboxymethylated pyridoindoles, characterized by antioxidant activity combined with the ability to inhibit aldose reductase, represent an example of a multitarget approach to the treatment of diabetic complications - severe diabetes-related he
Publikováno v:
Interdisciplinary Toxicology
Previously, the pyridoindole SMe1EC2 was proved to inhibit lipoperoxidation and carbonylation of proteins in rat brain cortex in the system Fe(2+)/ascorbate and improvement of resistance of the rat hippocampus was reported against ischemic conditions
Autor:
Ol'ga Ondrejicková, Cinzia Mascia, Katarína Bauerová, Mária Stančíková, Danica Mihalova, Viera Jančinová, Giuseppe Poli, Vladimir Snirc, Radomír Nosál, Silvester Ponist
Publikováno v:
Acta biochimica Polonica. 57(2)
The aim of this study was to evaluate the therapeutic potential of oxidative stress (OS) reduction by using pyridoindole (PI) antioxidants in adjuvant arthritis (AA). The substances tested were stobadine dipalmitate (STB) and SMe1. AA was used as ani