Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Vladimír Rudajev"'
Publikováno v:
Acta Montanistica Slovaca, Vol 15, Iss 2, Pp 145-151 (2010)
The new approach to the P-wave arrival time determination based on acoustic emission data from loading experiments is tested.The algorithm used in this paper is built on the STA/LTA function computed by a convolution that speeds up the computation pr
Externí odkaz:
https://doaj.org/article/ab977d35d8234ab2a962f077522d6d8c
Autor:
Eva Machová, Vladimír Rudajev, Helena Smyčková, Henna Koivisto, Heikki Tanila, Vladimír Doležal
Publikováno v:
Neurobiology of Disease, Vol 38, Iss 1, Pp 27-35 (2010)
We investigated the functional characteristics of pre- and postsynaptic cholinergic transmission in APPswe/PS1dE9 double transgenic mice at a young age (7-10 weeks) before the onset of amyloid plaque formation and at adult age (5-6 months) at its ons
Externí odkaz:
https://doaj.org/article/7a87953ec4a14df6bc5ef8502288ddf6
Publikováno v:
British Journal of Pharmacology. 175:1731-1743
Background & Purpose The aim of this study was to develop potent and long-acting antagonists of muscarinic acetylcholine receptors. 4-hexyloxy and 4-butyloxy derivatives of 1-[2-(4-oxidobenzoyloxy)ethyl]-1,2,3,6-tetrahydropyridin-1-ium were synthesiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::076cae4d83b88d55d5791f42920075d6
https://doi.org/10.1111/bph.14187
https://doi.org/10.1111/bph.14187
Autor:
Vladimir Rudajev, Jiri Novotny
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-23 (2023)
Abstract Amyloid β is considered a key player in the development and progression of Alzheimer’s disease (AD). Many studies investigating the effect of statins on lowering cholesterol suggest that there may be a link between cholesterol levels and
Externí odkaz:
https://doaj.org/article/6f3c8bd9b9994db2951afd8edf5c355a
Autor:
Vladimír Doležal, Jan Jakubík, Vladimír Rudajev, Pavel Zimčík, Alena Randáková, Esam E. El-Fakahany
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Proper determination of agonist efficacy is essential in the assessment of agonist selectivity and signalling bias. Agonist efficacy is a relative term that is dependent on the system in which it is measured, especially being dependent on receptor ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117f7a83dba26cae936bb03f3a8bcbff
https://doi.org/10.1038/s41598-019-40993-w
https://doi.org/10.1038/s41598-019-40993-w
Publikováno v:
International Journal of Rock Mechanics and Mining Sciences. 88:235-241
In this study, surface seismic measurements in the field at a rock outcrop (peridotite) and laboratory high frequency seismic measurements of spherical rock samples were compared. Both the field and the laboratory velocities of P- and S- waves were d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f7b36de138dc7e6eaf492087d1f8af0
https://doi.org/10.1016/j.ijrmms.2016.07.027
https://doi.org/10.1016/j.ijrmms.2016.07.027
Autor:
Heikki Tanila, Eva Dolejší, Helena Janickova, Jan Jakubík, Esam E. El-Fakahany, Hennariikka Koivisto, Vladimír Rudajev, Vladimir Dolezal
Publikováno v:
Current Alzheimer Research. 12:923-931
Transgenic APPswe/PS1dE9 mice modeling Alzheimer's disease demonstrate ongoing accumulation of β-amyloid fragments resulting in formation of amyloid plaques that starts at the age of 4-5 months. Buildup of β-amyloid fragments is accompanied by impa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d525235524d5a15a8fce4534e3f1d8
https://doi.org/10.2174/1567205012666151027130350
https://doi.org/10.2174/1567205012666151027130350
Publikováno v:
British Journal of Pharmacology
Background and Purpose The aim of this study was to develop potent and long‐acting antagonists of muscarinic ACh receptors. The 4‐hexyloxy and 4‐butyloxy derivatives of 1‐[2‐(4‐oxidobenzoyloxy)ethyl]‐1,2,3,6‐tetrahydropyridin‐1‐iu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d8d4aa6562b57a310a17501398bbee3b
https://pubmed.ncbi.nlm.nih.gov/29498041
https://pubmed.ncbi.nlm.nih.gov/29498041
Autor:
Pavel Zimčík, Eva Dolejší, Vladimír Rudajev, Vladimír Doležal, Jan Jakubík, Alena Randáková, Esam E. El-Fakahany
Publikováno v:
Neuropharmacology. 133
Xanomeline (3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole) is a muscarinic agonist that is considered to be functionally selective for the M1/M4 receptor subtypes. Part of xanomeline binding is resistant to washing. Wash-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfc473597836d4bf081faa2fd3c0f46
https://pubmed.ncbi.nlm.nih.gov/29407765
https://pubmed.ncbi.nlm.nih.gov/29407765
Publikováno v:
International Journal of Rock Mechanics and Mining Sciences. 60:208-216
A method of velocity anisotropy analysis based on conventional ultrasonic transmission technique is proposed. Multiple transducers are used both to monitor acoustic emission and to measure velocities in different propagation directions. A sparse netw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc779c529d3ebe87bede032332340fff
https://doi.org/10.1016/j.ijrmms.2012.12.020
https://doi.org/10.1016/j.ijrmms.2012.12.020