Výsledky vyhledávání - "Vladimír Garaj"

Akademický článek

Optimization and Comparison of Synthetic Procedures for a Group of Triazinyl-Substituted Benzene-Sulfonamide Conjugates with Amino Acids

Autor: Dominika Krajčiová, Daniel Pecher, Vladimír Garaj, Peter Mikuš

Publikováno v: Molecules, Vol 22, Iss 9, p 1533 (2017)

Sulfonamides incorporating 1,3,5-triazine moieties can selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII, and XIV over cytosolic isoforms I and II. In the present work, a highly effective synthetic procedure was propo

Externí odkaz: https://doaj.org/article/c9cdccc29bd3426bbc5d3255fa6c0afb

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Akademický článek

7-Dialkylaminocoumarin Oximates: Small Molecule Fluorescent 'Turn-On' Chemosensors for Low-Level Water Content in Aprotic Organic Solvents

Autor: Marek Cigáň, Miroslav Horváth, Juraj Filo, Klaudia Jakusová, Jana Donovalová, Vladimír Garaj, Anton Gáplovský

Publikováno v: Molecules, Vol 22, Iss 8, p 1340 (2017)

The water sensing properties of two efficient two-component fluorescent “turn-on” chemo-sensors based on the 7-dialkylaminocoumarin oxime acid-base equilibrium were investigated. Interestingly, although simple frontier orbital analysis predicts a

Externí odkaz: https://doaj.org/article/14c93bf71cc34001be8f8904ad24f27f

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Novel 1,3,5-Triazinyl Aminobenzenesulfonamides Incorporating Aminoalcohol, Aminochalcone and Aminostilbene Structural Motifs as Potent Anti-VRE Agents, and Carbonic Anhydrases I, II, VII, IX, and XII Inhibitors

Autor: Eva Havránková, Vladimír Garaj, Šárka Mascaretti, Andrea Angeli, Zuzana Soldánová, Miroslav Kemka, Jozef Motyčka, Marie Brázdová, Jozef Csöllei, Josef Jampílek, Claudiu T. Supuran

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 231, p 231 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 231

A series of 1,3,5-triazinyl aminobenzenesulfonamides substituted by aminoalcohol, aminostilbene, and aminochalcone structural motifs was synthesized as potential human carbonic anhydrase (hCA) inhibitors. The compounds were evaluated on their inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94d142e1284716e7d58e5015931506d
https://www.mdpi.com/1422-0067/23/1/231

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Enantioseparation of citalopram enantiomers by capillary electrophoresis: Method development through experimental design and computational modeling

Autor: Vladimír Garaj, Anca Gabriela Cârje, Monica Budău, Lajos Attila Papp, Daniela Lucia Muntean, Gabriel Hancu

Publikováno v: Chirality. 32:1119-1128

Citalopram (CIT) is a frequently used modern antidepressant that inhibits selectively serotonin reuptake in the brain. It has a chiral center in its structure and is used in therapy as both racemic mixture and pure enantiomer as its pharmacological e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12eb434cf64e99621029125b6479be05
https://doi.org/10.1002/chir.23255

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Novel sulfonamides incorporating 1,3,5-triazine and amino acid structural motifs as inhibitors of the physiological carbonic anhydrase isozymes I, II and IV and tumor-associated isozyme IX

Autor: Branislav Horváth, Peter Mikuš, Claudiu T. Supuran, Dominika Krajčiová, Andrea Angeli, Mária Bodnár Mikulová, Vladimír Garaj, Daniel Pecher, Silvia Bua

Publikováno v: Bioorganic Chemistry. 81:241-252

A new series of thirty s-triazinyl-substituted aminoalkylbenzenesulfonamides, incorporating a symmetric pair of amino acid moieties, is reported, together with inhibition studies of physiologically relevant human carbonic anhydrase (hCA, EC 4.2.1.1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcf9db471db867a698a62f6588e96aa
https://doi.org/10.1016/j.bioorg.2018.08.005

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Venlafaxine Chiral Separation by Capillary Electrophoresis Using Cyclodextrin Derivatives as Chiral Selector and Experimental Design Method Optimization

Autor: Hajnal Kelemen, Daniela Lupu, Gabriel Hancu, Monica Budău, Andreea Milan, Vladimír Garaj

Publikováno v: Symmetry
Volume 12
Issue 5
Symmetry, Vol 12, Iss 849, p 849 (2020)

Venlafaxine (VFX) is a modern antidepressant from the serotonin and norepinephrine reuptake inhibitor (SNRI) class. It is a chiral substance used in therapy as a racemate, but differences between the pharmacological properties of the two enantiomers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433b01f40b67c6a8356782e662c264e2

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Novel sulfonamide incorporating piperazine, aminoalcohol and 1,3,5-triazine structural motifs with carbonic anhydrase I, II and IX inhibitory action

Autor: Claudiu T. Supuran, Vladimír Garaj, Jozef Csöllei, Daniela Vullo, Eva Havránková, Pavel Pazdera

Publikováno v: Bioorganic Chemistry. 77:25-37

A new series of s-triazine derivatives incorporating sulfanilamide, homosulfanilamide, 4-aminoethyl-benzenesulfonamide and piperazine or aminoalcohol structural motifs is reported. Molecular docking was exploited to select compounds from virtual comb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08abb49d2edb5a1e3425a63d576c365
https://doi.org/10.1016/j.bioorg.2017.12.034

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Virtual screening of combinatorial library of novel benzenesulfonamides on mycobacterial carbonic anhydrase II

Autor: F. Dikant, Vladimír Garaj, F. Gáplovský

Publikováno v: European Pharmaceutical Journal, Vol 63, Iss 2, Pp 1-6 (2016)

Combinatorial library of novel benzenesulfonamides was docked (Schrodinger Glide) into mycobacterial carbonic anhydrase (mtCA II) and human (hCA II) isoforms with an aim to find drug candidates with selective activity on mtCA II. The predicted select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60044f3bd3e6ce49e056cd3b5ff42d54
https://doi.org/10.1515/afpuc-2016-0020

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Photoswitching hydrazones based on benzoylpyridine

Autor: Andrea Bianco, Vladimír Garaj, Mariachiara Mantero, Klaudia Csicsai, Bernard Mravec, Juraj Filo, Marek Cigáň, Anna Marini, Miroslav Kemka

Publikováno v: Physical chemistry chemical physics : PCCP. 21(44)

The photoswitching properties of three readily accesible benzoylpyridine hydrazones were investigated. Interestingly, replacing classical stirring with ultrasound wave activation results in pure thermodynamically less stable E isomer crystallization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff448392ccac654bde5411de4834fd4
https://pubmed.ncbi.nlm.nih.gov/31681942

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