Optimization and Comparison of Synthetic Procedures for a Group of Triazinyl-Substituted Benzene-Sulfonamide Conjugates with Amino Acids

Autor: Dominika Krajčiová, Daniel Pecher, Vladimír Garaj, Peter Mikuš

Publikováno v: Molecules, Vol 22, Iss 9, p 1533 (2017)

Sulfonamides incorporating 1,3,5-triazine moieties can selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII, and XIV over cytosolic isoforms I and II. In the present work, a highly effective synthetic procedure was propo

Externí odkaz: https://doaj.org/article/c9cdccc29bd3426bbc5d3255fa6c0afb

Novel 1,3,5-Triazinyl Aminobenzenesulfonamides Incorporating Aminoalcohol, Aminochalcone and Aminostilbene Structural Motifs as Potent Anti-VRE Agents, and Carbonic Anhydrases I, II, VII, IX, and XII Inhibitors

Autor: Eva Havránková, Vladimír Garaj, Šárka Mascaretti, Andrea Angeli, Zuzana Soldánová, Miroslav Kemka, Jozef Motyčka, Marie Brázdová, Jozef Csöllei, Josef Jampílek, Claudiu T. Supuran

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 231, p 231 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 231

A series of 1,3,5-triazinyl aminobenzenesulfonamides substituted by aminoalcohol, aminostilbene, and aminochalcone structural motifs was synthesized as potential human carbonic anhydrase (hCA) inhibitors. The compounds were evaluated on their inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94d142e1284716e7d58e5015931506d
https://www.mdpi.com/1422-0067/23/1/231

Novel sulfonamides incorporating 1,3,5-triazine and amino acid structural motifs as inhibitors of the physiological carbonic anhydrase isozymes I, II and IV and tumor-associated isozyme IX

Autor: Branislav Horváth, Peter Mikuš, Claudiu T. Supuran, Dominika Krajčiová, Andrea Angeli, Mária Bodnár Mikulová, Vladimír Garaj, Daniel Pecher, Silvia Bua

Publikováno v: Bioorganic Chemistry. 81:241-252

A new series of thirty s-triazinyl-substituted aminoalkylbenzenesulfonamides, incorporating a symmetric pair of amino acid moieties, is reported, together with inhibition studies of physiologically relevant human carbonic anhydrase (hCA, EC 4.2.1.1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcf9db471db867a698a62f6588e96aa
https://doi.org/10.1016/j.bioorg.2018.08.005

Novel sulfonamide incorporating piperazine, aminoalcohol and 1,3,5-triazine structural motifs with carbonic anhydrase I, II and IX inhibitory action

Autor: Claudiu T. Supuran, Vladimír Garaj, Jozef Csöllei, Daniela Vullo, Eva Havránková, Pavel Pazdera

Publikováno v: Bioorganic Chemistry. 77:25-37

A new series of s-triazine derivatives incorporating sulfanilamide, homosulfanilamide, 4-aminoethyl-benzenesulfonamide and piperazine or aminoalcohol structural motifs is reported. Molecular docking was exploited to select compounds from virtual comb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08abb49d2edb5a1e3425a63d576c365
https://doi.org/10.1016/j.bioorg.2017.12.034

Photoswitching hydrazones based on benzoylpyridine

Autor: Andrea Bianco, Vladimír Garaj, Mariachiara Mantero, Klaudia Csicsai, Bernard Mravec, Juraj Filo, Marek Cigáň, Anna Marini, Miroslav Kemka

Publikováno v: Physical chemistry chemical physics : PCCP. 21(44)

The photoswitching properties of three readily accesible benzoylpyridine hydrazones were investigated. Interestingly, replacing classical stirring with ultrasound wave activation results in pure thermodynamically less stable E isomer crystallization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff448392ccac654bde5411de4834fd4
https://pubmed.ncbi.nlm.nih.gov/31681942