Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Vladimír Divoký"'
Autor:
Emanuel Maethner, Maria-Paz Garcia-Cuellar, Constanze Breitinger, Sylvia Takacova, Vladimir Divoky, Jay L. Hess, Robert K. Slany
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1553-1566 (2013)
Stimulation of transcriptional elongation is a key activity of leukemogenic MLL fusion proteins. Here, we provide evidence that MLL-ENL also inhibits Polycomb-mediated silencing as a prerequisite for efficient transformation. Biochemical studies iden
Externí odkaz:
https://doaj.org/article/640a9373d2684bb197a168258ccb394f
Publikováno v:
Haematologica, Vol 100, Iss 8 (2015)
Externí odkaz:
https://doaj.org/article/8ff49f30f67f4d069249a0ac95eb7402
Autor:
Dagmar Pospisilova, Dusan Holub, Zuzana Zidova, Lucie Sulovska, Jiri Houda, Vladimir Mihal, Ivana Hadacova, Lenka Radova, Petr Dzubak, Marian Hajduch, Vladimir Divoky, Monika Horvathova
Publikováno v:
Haematologica, Vol 99, Iss 7 (2014)
Externí odkaz:
https://doaj.org/article/0bf8e8df7bb646a68d8e1e4437687aa2
Autor:
Monika Horvathova, Katarina Kapralova, Zuzana Zidova, Dalibor Dolezal, Dagmar Pospisilova, Vladimir Divoky
Publikováno v:
Haematologica, Vol 97, Iss 10 (2012)
Background Hypochromic microcytic anemia associated with ineffective erythropoiesis caused by recessive mutations in divalent metal transporter 1 (DMT1) can be improved with high-dose erythropoietin supplementation. The aim of this study was to chara
Externí odkaz:
https://doaj.org/article/3182d082aa244e0cb4b6eff13443f91b
Autor:
Lucia Vráblová, Vladimír Divoký, Pavla Kořalková, Kateřina Machová Poláková, Eva Kriegová, Romana Janská, Jan Grohmann, Milena Holzerová, Tomáš Papajík, Edgar Faber
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2050 (2023)
The treatment outcome in patients with chronic myeloid leukaemia (CML) in blast crisis (BC) is unsatisfactory despite the use of allogeneic stem cell transplantation (ASCT). Moreover, in some patients ASCT is contraindicated, with limited treatment o
Externí odkaz:
https://doaj.org/article/a737d387330d491f96f3a793bafbcf86
Autor:
Karel Indrák, Martina Divoká, Dagmar Pospíšilová, Jaroslav Čermák, Monika Beličková, Monika Horváthová, Vladimír Divoký
Publikováno v:
Vnitřní lékařství. 64:476-487
Autor:
Karel Berka, Zuzana Klejová, Eva Řezníčková, Veronika Malínková, Tereza Radosova Muchova, Martin Lepšík, Haresh Ajani, Vladimír Divoký, Vladimír Kryštof, Radek Jorda, Václav Bazgier, Tomáš Gucký
Publikováno v:
Journal of Medicinal Chemistry. 61:3855-3869
FLT3 tyrosine kinase is a potential drug target in acute myeloid leukemia (AML) because patients with FLT3-ITD mutations respond poorly to standard cytotoxic agents and there is a clear link between the disease and the oncogenic properties of FLT3. W
Autor:
Tomáš, Gucký, Eva, Řezníčková, Tereza, Radošová Muchová, Radek, Jorda, Zuzana, Klejová, Veronika, Malínková, Karel, Berka, Václav, Bazgier, Haresh, Ajani, Martin, Lepšík, Vladimír, Divoký, Vladimír, Kryštof
Publikováno v:
Journal of medicinal chemistry. 61(9)
FLT3 tyrosine kinase is a potential drug target in acute myeloid leukemia (AML) because patients with FLT3-ITD mutations respond poorly to standard cytotoxic agents and there is a clear link between the disease and the oncogenic properties of FLT3. W
Autor:
Katarina Kapralova, Ondrej Jahoda, Pavla Koralkova, Jan Gursky, Lucie Lanikova, Dagmar Pospisilova, Vladimir Divoky, Monika Horvathova
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9652 (2020)
Molecular pathophysiology of Diamond-Blackfan anemia (DBA) involves disrupted erythroid-lineage proliferation, differentiation and apoptosis; with the activation of p53 considered as a key component. Recently, oxidative stress was proposed to play an
Externí odkaz:
https://doaj.org/article/2f3561f009884126b9f5644395a57b01
Autor:
Zuzana Zidova, Katarina Kapralova, Pavla Koralkova, Renata Mojzikova, Dalibor Dolezal, Vladimir Divoky, Monika Horvathova
Publikováno v:
Cellular Physiology and Biochemistry, Vol 34, Iss 6, Pp 2221-2231 (2014)
Background/Aims: Deficiency of the divalent metal transporter 1 (DMT1) leads to hypochromic microcytic anemia. We have previously shown that DMT1 deficiency impairs erythroid differentiation and induces apoptosis of erythroid cells. Here we analyzed
Externí odkaz:
https://doaj.org/article/92d214de61fb45f293f83625d43eee46