Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Vladimír Chytrý"'
Publikováno v:
Macromolecular Rapid Communications. 18:107-111
Time-dependent phase separation/transition was observed in aqueous solutions of poly(N-isopropylmethacrylamide) in the temperature range 38–42°C. The time before the second phase appears is a function of temperature and may reach up to several hou
Publikováno v:
Journal of Controlled Release. 16:255-262
The purpose of this study was to try to identify extrahepatic galactose-mediated recognition systems of potential therapeutic value, in order to permit study of galactose-mediated interactions in peripheral sites, possibly of low affinity, a HPMA-bas
Publikováno v:
Die Makromolekulare Chemie. 179:329-336
Insulin bound on a polymer carrier has been prepared by a reaction of insulin with the copolymer of N-(2-hydroxypropyl)methacrylamide and N-methacryloyldiglycyl p-nitrophenyl ester. The product isolated by gel chromatography contains ca. 60 wt.-% of
Publikováno v:
Die Makromolekulare Chemie. 9:35-42
A covalently bound complex of acetylcholinesterase with poly[N-(2-hydroxypropyl) methacrylamide] has been obtained, showing a 70-fold prolongation of the acetylcholinesterase activity survival in mouse blood after intravenous injection of the modifie
Publikováno v:
Collection of Czechoslovak Chemical Communications. 46:1466-1473
Chymotrypsin has been covalently bound on a water-soluble biocompatible carrier poly[N-(2-hydroxypropyl)methacrylamide] by three different methods. The catalytic activity of the polymer bound enzyme in the reaction with low-molecular substrates coinc
Autor:
Jindřich Kopeček, Vladimír Chytrý
Publikováno v:
Die Makromolekulare Chemie. 184:1345-1353
The amount of chymotrypsinogen linked to poly[N-(2-hydroxypropyl)methacrylamide], which was activated by cyanogen bromide, under various conditions was determined. The optimal activation time was found to be indicated by the beginning of an invariabl
Publikováno v:
Die Makromolekulare Chemie. 184:1339-1344
Proper reaction conditions were determined for the activation of water-soluble, biocompatible poly[N-(2-hydroxypropyl)methacrylamide] (1) by esterification with 4-nitrophenyl chloroformate (2). The rate constants of hydrolysis and aminolysis of the 4
Publikováno v:
Die Makromolekulare Chemie. 9:13-24
The homopolymer of N-(2-hydroxypropyl)methacrylamide (HPMA) and copolymers of HPMA differing in oligopeptide side chains (-Gly-Gly-OH;-Acap-Phe-OH;-Acap-Leu-HMDA and -Gly-Phe-Tyr-OH) or in their content (1.0, 3.5 and 8.4 mol. % of -Gly-Gly-OH side ch
Publikováno v:
Die Makromolekulare Chemie, Rapid Communications. 3:11-15
Publikováno v:
Die Makromolekulare Chemie. 182:799-809
A series of copolymers of N-(2-hydroxypropyl)methacrylamide were prepared, which contained side chains of the general formula -Gly-X-Y-NAp, where Gly ¨ glycine; X ¨ glycine, alanine, β-alanine, valine, leucine, isoleucine, phenylalanine; Y ¨ phen