Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Vlad Kovalik"'
Autor:
Amber L. Southwell, Sonia Franciosi, Erika B. Villanueva, Yuanyun Xie, Laurie A. Winter, Janaki Veeraraghavan, Alan Jonason, Boguslaw Felczak, Weining Zhang, Vlad Kovalik, Sabine Waltl, George Hall, Mahmoud A. Pouladi, Ernest S. Smith, William J. Bowers, Maurice Zauderer, Michael R. Hayden
Publikováno v:
Neurobiology of Disease, Vol 76, Iss , Pp 46-56 (2015)
Huntington disease (HD) is an inherited, fatal neurodegenerative disease with no disease-modifying therapy currently available. In addition to characteristic motor deficits and atrophy of the caudate nucleus, signature hallmarks of HD include behavio
Externí odkaz:
https://doaj.org/article/99a93dc1282c4cf6b5dc56f2438c4a79
Autor:
Bibiana K.Y. Wong, Dagmar E. Ehrnhoefer, Rona K. Graham, Dale D.O. Martin, Safia Ladha, Valeria Uribe, Lisa M. Stanek, Sonia Franciosi, Xiaofan Qiu, Yu Deng, Vlad Kovalik, Weining Zhang, Mahmoud A. Pouladi, Lamya S. Shihabuddin, Michael R. Hayden
Publikováno v:
Neurobiology of Disease, Vol 76, Iss , Pp 24-36 (2015)
Huntington Disease (HD) is a progressive neurodegenerative disease caused by an elongated CAG repeat in the huntingtin (HTT) gene that encodes a polyglutamine tract in the HTT protein. Proteolysis of the mutant HTT protein (mHTT) has been detected in
Externí odkaz:
https://doaj.org/article/93e64c557c8447099a3caa50455f7c0b
Autor:
Michael R. Hayden, Rona K. Graham, Xiaofan Qiu, Mahmoud A. Pouladi, Dale D.O. Martin, Lisa M. Stanek, Yu Deng, Safia Ladha, Vlad Kovalik, Lamya S. Shihabuddin, Dagmar E. Ehrnhoefer, Bibiana K. Y. Wong, Valeria Uribe, Sonia Franciosi, Weining Zhang
Publikováno v:
Neurobiology of Disease, Vol 76, Iss, Pp 24-36 (2015)
Huntington Disease (HD) is a progressive neurodegenerative disease caused by an elongated CAG repeat in the huntingtin (HTT) gene that encodes a polyglutamine tract in the HTT protein. Proteolysis of the mutant HTT protein (mHTT) has been detected in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ab4cf341a673da5f8b052ab51aedf4
https://doi.org/10.1016/j.nbd.2014.12.030
https://doi.org/10.1016/j.nbd.2014.12.030
Autor:
Boguslaw Felczak, Sabine Waltl, George Hall, Erika B. Villanueva, Yuanyun Xie, Michael R. Hayden, Weining Zhang, Ernest S. Smith, Amber L. Southwell, Maurice Zauderer, Vlad Kovalik, Laurie A. Winter, Alan S. Jonason, Sonia Franciosi, William J. Bowers, Mahmoud A. Pouladi, Janaki Veeraraghavan
Publikováno v:
Neurobiology of Disease, Vol 76, Iss, Pp 46-56 (2015)
Huntington disease (HD) is an inherited, fatal neurodegenerative disease with no disease-modifying therapy currently available. In addition to characteristic motor deficits and atrophy of the caudate nucleus, signature hallmarks of HD include behavio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4695d8f490b8ca0232dade08a084827b
https://doi.org/10.1016/j.nbd.2015.01.002
https://doi.org/10.1016/j.nbd.2015.01.002
Autor:
Amber L. Southwell, Katherine K. N. Mui, Crystal N. Doty, Liza M. Sutton, Fiona B. Young, Michael R. Hayden, Shaun S. Sanders, Weining Zhang, Sonia Franciosi, Roshni R. Singaraja, Vlad Kovalik, Mandi E. Schmidt, Stefanie L. Butland
Publikováno v:
Human Molecular Genetics. 22:452-465
Palmitoylation, the dynamic post-translational addition of the lipid, palmitate, to proteins by Asp-His-His-Cys-containing palmitoyl acyltransferase (PAT) enzymes, modulates protein function and localization and plays a key role in the nervous system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2b51de409bad8836f93c7eca3e2361
https://doi.org/10.1093/hmg/dds441
https://doi.org/10.1093/hmg/dds441
Autor:
Michael R. Hayden, X. William Yang, Erika B. Villanueva, Niels H. Skotte, Crystal N. Doty, Amber L. Southwell, Jeffrey B. Carroll, Vlad Kovalik, Sonia Franciosi, Weining Zhang, Mahmoud A. Pouladi, Jennifer A. Collins, Simon C. Warby, Yuanyun Xie
Publikováno v:
Human Molecular Genetics. 22:18-34
Silencing the mutant huntingtin gene (muHTT) is a direct and simple therapeutic strategy for the treatment of Huntington disease (HD) in principle. However, targeting the HD mutation presents challenges because it is an expansion of a common genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1b299ddb98f5fe7f29092cae6621d9
https://doi.org/10.1093/hmg/dds397
https://doi.org/10.1093/hmg/dds397