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Akademický článek

Myocardial steatosis across the spectrum of human health and disease

Autor: Andrew P. Oneglia, Lidia S. Szczepaniak, Vlad G. Zaha, Michael D. Nelson

Publikováno v: Experimental Physiology, Vol 109, Iss 2, Pp 202-213 (2024)

Abstract Preclinical data strongly suggest that myocardial steatosis leads to adverse cardiac remodelling and left ventricular dysfunction. Using 1H cardiac magnetic resonance spectroscopy, similar observations have been made across the spectrum of h

Externí odkaz: https://doaj.org/article/e03bfa49bdb94edd8888205abeb8adae

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Akademický článek

Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.

Publikováno v: PLoS Biology, Vol 4, Iss 11, p e369 (2006)

The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1beta (PGC-1beta) has been implicated in important metabolic processes. A mouse lacking PGC-1beta (PGC1betaKO) was generated and phenotyped using physiologic

Externí odkaz: https://doaj.org/article/a339d534b4bb4152b54fabbda95e6768

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Akademický článek

Cardiovascular perspectives on stem cell transplant and Car-T cell therapy: The old and the new for assessment and management

Autor: Anjali Rao, Vlad G. Zaha

Publikováno v: American Heart Journal Plus, Vol 22, Iss , Pp 100198- (2022)

Externí odkaz: https://doaj.org/article/3229c49f767b4fdebc8ee73a2d952c7f

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Akademický článek

Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Heart failure with preserved ejection fraction (HFpEF) is a global, major health issue for which no effective therapies are available. Here, the authors discover that the interplay between two transcription factors, Xbp1s and FoxO1, is critical for m

Externí odkaz: https://doaj.org/article/5e96ad72a7fc4e428e30cd13deb2825b

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Akademický článek

Assessment of Rapid Hepatic Glycogen Synthesis in Humans Using Dynamic 13C Magnetic Resonance Spectroscopy

Autor: Stefan Stender, Vlad G. Zaha, Craig R. Malloy, Jessica Sudderth, Ralph J. DeBerardinis, Jae Mo Park

Publikováno v: Hepatology Communications, Vol 4, Iss 3, Pp 425-433 (2020)

Carbon‐13 magnetic resonance spectroscopy (MRS) following oral intake of 13C‐labeled glucose is the gold standard for imaging glycogen metabolism in humans. However, the temporal resolution of previous studies has been >13 minutes. Here, we descr

Externí odkaz: https://doaj.org/article/e975fa7feda54cc8ba025fb0cc728917

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Akademický článek

Efficacy of Neurohormonal Therapies in Preventing Cardiotoxicity in Patients With Cancer Undergoing Chemotherapy

Autor: Muthiah Vaduganathan, MD, MPH, Sameer A. Hirji, MD, MPH, Arman Qamar, MD, Navkaranbir Bajaj, MD, MPH, Ankur Gupta, MD, PhD, Vlad G. Zaha, MD, Alvin Chandra, MD, Mark Haykowsky, PhD, Bonnie Ky, MD, MSCE, Javid Moslehi, MD, Anju Nohria, MD, Javed Butler, MD, MPH, MBA, Ambarish Pandey, MD, MSCS

Publikováno v: JACC. CardioOncology, Vol 1, Iss 1, Pp 54-65 (2019)

Objectives: This study sought to assess the effects of neurohormonal therapies in preventing cardiotoxicity in patients receiving chemotherapy. Background: Various cardioprotective approaches have been evaluated to prevent chemotherapy-related cardio

Externí odkaz: https://doaj.org/article/40f9d47a2efc4997b25c909e78ba9746

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