Copper sensing transcription factor ArsR2 regulates VjbR to sustain virulence in Brucella abortus

Autor: Feijie Zhi, Kemeng Liu, Hao Geng, Mengru Su, Jian Xu, Lei Fu, Ke Ma, Pengcheng Gao, Lvfeng Yuan, YueFeng Chu

Publikováno v: Emerging Microbes and Infections, Vol 13, Iss 1 (2024)

Brucellosis, caused by the intracellular pathogen Brucella, is a major zoonotic infection that promotes reproductive disease in domestic animals and chronic debilitating conditions in humans. The ArsR family of transcriptional regulators plays key ro

Externí odkaz: https://doaj.org/article/9fb962bdfd0a480ea3d05e8e6211e886

Brucella Rough Mutant Induce Macrophage Death via Activating IRE1α Pathway of Endoplasmic Reticulum Stress by Enhanced T4SS Secretion

Autor: Peng Li, Mingxing Tian, Yanqing Bao, Hai Hu, Jiameng Liu, Yi Yin, Chan Ding, Shaohui Wang, Shengqing Yu

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)

Brucella is a Gram-negative facultative intracellular pathogen that causes the worldwide zoonosis, known as brucellosis. Brucella virulence relies mostly on its ability to invade and replicate within phagocytic cells. The type IV secretion system (T4

Externí odkaz: https://doaj.org/article/0c1fe3c60998485b9d83f0f00ba3c970

ChIP-seq analysis of the LuxR-type regulator VjbR reveals novel insights into the Brucella virulence gene expression network

Autor: Rodrigo Sieira, Hernán Ruy Bonomi, Claudia L. Kleinman, Romina M. Rodríguez, Gabriela Sycz, Angeles Zorreguieta

Publikováno v: Nucleic Acids Research
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

LuxR-type transcription factors control diverse physiological functions necessary for bacterial adaptation to environmental changes. In the intracellular pathogen Brucella, the LuxR homolog VjbR has been shown to regulate the expression of virulence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c2fbcc8029f9fe43a0a167e2ed16c5
http://europepmc.org/articles/PMC5449634

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Expression of VjbR under Nutrient Limitation Conditions Is Regulated at the Post-Transcriptional Level by Specific Acidic pH Values and Urocanic Acid

Autor: Rodrigo Sieira, Gastón Maximiliano Arocena, Angeles Zorreguieta

Publikováno v: PLoS ONE
PLoS ONE 2012;7(4)
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
PLoS ONE, Vol 7, Iss 4, p e35394 (2012)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

VjbR is a LuxR homolog that regulates transcription of many genes including important virulence determinants of the facultative intracellular pathogen Brucella abortus. This transcription factor belongs to a family of regulators that participate in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f4e2fbbe0e30dc73fd4ae2be9c90ae
http://europepmc.org/articles/PMC3328445