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Systematic Comparison of CRISPR and shRNA Screens to Identify Essential Genes Using a Graph-Based Unsupervised Learning Model.

Autor: Ding Y; Central for High-Performance Computing, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.; Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada.; Cancer Research Department, Saskatchewan Cancer Agency, Saskatoon, SK S7N 5E5, Canada., Denomy C; Division of Oncology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Freywald A; Department of Pathology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Pan Y; Central for High-Performance Computing, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.; Department of Computer Science and Control Engineering, Shenzhen University of Advanced Technology, Shenzhen 518055, China., Vizeacoumar FJ; Cancer Research Department, Saskatchewan Cancer Agency, Saskatoon, SK S7N 5E5, Canada.; Division of Oncology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Vizeacoumar FS; Department of Pathology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Wu FX; Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada.; Department of Mechanical Engineering, Department of Computer Science, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada.

Publikováno v: Cells [Cells] 2024 Oct 04; Vol. 13 (19). Date of Electronic Publication: 2024 Oct 04.

The EphA2 Receptor Regulates Invasiveness and Drug Sensitivity in Canine and Human Osteosarcoma Cells.

Autor: Harris ED; Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N 5B4, Canada., Sharpe JC; Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N 5B4, Canada., Strozen T; Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N 5B4, Canada., Abdi S; Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N 5B4, Canada., Kliewer M; Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N 5B4, Canada., Sanchez MG; Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N 5B4, Canada.; Department of Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan, GA20 Health Sciences, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada., Hogan NS; Department of Animal and Poultry Science, College of Agriculture and Bioresources, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK S7N 5A8, Canada., MacDonald-Dickinson V; Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N 5B4, Canada., Vizeacoumar FJ; Cancer Research, Saskatchewan Cancer Agency and Division of Oncology, University of Saskatchewan, Health Sciences Building, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada., Toosi BM; Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N 5B4, Canada.

Publikováno v: Cells [Cells] 2024 Jul 16; Vol. 13 (14). Date of Electronic Publication: 2024 Jul 16.

Breast Tumor Metastasis and Its Microenvironment: It Takes Both Seed and Soil to Grow a Tumor and Target It for Treatment.

Autor: Bonni S; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB T2N 4N1, Canada.; The Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB T2N 4N1, Canada., Brindley DN; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada., Chamberlain MD; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 0W8, Canada.; Saskatchewan Cancer Agency, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada., Daneshvar-Baghbadorani N; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 0W8, Canada.; Saskatchewan Cancer Agency, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada., Freywald A; Department of Pathology, Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Hemmings DG; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada.; Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB T6G 2S2, Canada.; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada., Hombach-Klonisch S; Department of Human Anatomy and Cell Science, Faculty of Health Sciences, College of Medicine, University of Manitoba, Winnipeg, MB R3T 2N2, Canada., Klonisch T; Department of Human Anatomy and Cell Science, Faculty of Health Sciences, College of Medicine, University of Manitoba, Winnipeg, MB R3T 2N2, Canada., Raouf A; Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E OT5, Canada.; Cancer Care Manitoba Research Institute, Cancer Care Manitoba, Winnipeg, MB R3E OV9, Canada., Shemanko CS; The Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.; Department of Biological Sciences, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada., Topolnitska D; Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E OT5, Canada.; Cancer Care Manitoba Research Institute, Cancer Care Manitoba, Winnipeg, MB R3E OV9, Canada., Visser K; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada.; Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB T6G 2S2, Canada.; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada., Vizeacoumar FJ; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 0W8, Canada.; Saskatchewan Cancer Agency, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada., Wang E; Department of Biochemistry and Molecular Biology, Medical Genetics, and Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada., Gibson SB; Department of Oncology, University of Alberta, Edmonton, AB T6G 2R3, Canada.

Publikováno v: Cancers [Cancers (Basel)] 2024 Feb 23; Vol. 16 (5). Date of Electronic Publication: 2024 Feb 23.