Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Vivienne Sanderson"'
Autor:
Denise J. Burring, Carly L. Nichols, Vivienne Sanderson, David V. Batchelor, Charlotte Moira Norfor Allerton, Andrew Simon Cook, Julian Blagg, Joanne Phipps, Hugh Verrier, Stephen K.-F. Wong, Andrew Douglas Baxter, Christopher L. Carr
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6691-6696
This paper reports the synthesis and biological activity of a novel series of aryl-morpholine dopamine receptor agonists. Several compounds show high levels of functional selectivity for the D3 over the D2 dopamine receptor. Compound 26 has >1000-fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb0e1aac944b12f621b121b1b4a63c5
https://doi.org/10.1016/j.bmcl.2007.10.059
https://doi.org/10.1016/j.bmcl.2007.10.059
Autor:
Laura Foster, Michelle Y. Platts, Peter Stacey, Stephanie Foll, Sara Coggon, Christopher Kohl, Denise J. Burring, Vivienne Sanderson, Kevin Beaumont, Lyn H. Jones, Alan Stobie, David C. Pryde, Martin Corless, Andrew Simon Cook, Donald Stuart Middleton, Piet H. van der Graaf, Laura Barker
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:142-159
A series of substituted glutaramides were synthesised using Candoxatrilat 1 as a lead and evaluated for potency against neutral endopeptidase (NEP) as a potential treatment for female sexual arousal disorder (FSAD). In this paper, we describe studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66291a2d2f51d2a67e5ae1dfe4a8b181
https://doi.org/10.1016/j.bmc.2006.10.002
https://doi.org/10.1016/j.bmc.2006.10.002
Autor:
Martin P. Green, Vivienne Sanderson, Gordon McMurray, Lesa Watson, Edel Evrard, Kevin K.-C. Liu, Michael J. Ralph, Charlotte Moira Norfor Allerton, Robin Ward, David Ellis, Andrews Mark David, Julian Blagg
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(19)
The SAR of a series of pyridazinone derived 5-HT 2C agonists has been explored and resulted in identification of a compound with excellent levels of 5-HT 2C functional agonism and selectivity over 5-HT 2A and 5-HT 2B . This compound displayed good in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2064b35c0d38ca034a9006643d1e0f
https://pubmed.ncbi.nlm.nih.gov/19716297
https://pubmed.ncbi.nlm.nih.gov/19716297
Autor:
Michelle Y. Platts, Piet H. van der Graaf, Simon Paul Planken, Laura Foster, Maw Graham Nigel, Peter Stacey, Vivienne Sanderson, Barber Christopher Gordon, Christopher Kohl, Christopher Peter Wayman, Rachel Jane Russell, Laura Barker, Alan Stobie, David C. Pryde, Michael S. Tute, Kevin Beaumont, Debbie Morren, Martin Corless, Sara Coggon
Publikováno v:
Journal of medicinal chemistry. 49(14)
Female sexual arousal disorder (FSAD) is a highly prevalent sexual disorder affecting up to 40% of women. We describe herein our efforts to identify a selective neutral endopeptidase (NEP) inhibitor as a potential treatment for FSAD. The rationale fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd50c3a049a4868ca4ebec65ed1ecd90
https://pubmed.ncbi.nlm.nih.gov/16821800
https://pubmed.ncbi.nlm.nih.gov/16821800
Autor:
Peter Stacey, David C. Pryde, Sara Coggon, Vivienne Sanderson, Kevin Beaumont, Maw Graham Nigel, Martin Corless, Michelle Y. Platts, Piet H. van der Graaf, Simon Paul Planken, Christopher Peter Wayman, Alan Stobie, Christopher Kohl
Publikováno v:
Chemical biologydrug design. 67(1)
A series of small molecule glutaramides were synthesized and evaluated for potency against canine and human neutral endopeptidase using target criteria of molecular weight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abaec5ac81a8f792665b9205193a2d1e
https://pubmed.ncbi.nlm.nih.gov/16492151
https://pubmed.ncbi.nlm.nih.gov/16492151