Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Vivien Tissen"'
Autor:
Lisa-Maria Winter, Diana Reinhardt, Ariane Schatter, Vivien Tissen, Heike Wiora, Daniel Gerlach, Ulrike Tontsch-Grunt, Florian Colbatzky, Birgit Stierstorfer, Seong-Wook Yun
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract GDF15 has recently emerged as a key driver of the development of various disease conditions including cancer cachexia. Not only the tumor itself but also adverse effects of chemotherapy have been reported to contribute to increased GDF15. Al
Externí odkaz:
https://doaj.org/article/824669cb47604d63b4686cf0ba92e957
Autor:
Zhiheng Zhang, Jörg Kleeff, Nadja Maeritz, Susanne Raulefs, Xiaoping Zou, Helmut Friess, Christina Ludwig, Dianbo Yao, Kathleen Schuck, Metello Innocenti, Yamin Zhao, Shanshan Shen, Vivien Tissen, Achim Krüger, Christoph W. Michalski, Jan G. D’Haese, Rob A. van der Kammen, Carsten Jäger, Benjamin Schoeps, Anna Melissa Schlitter, Bo Kong
Background & Aims Oncogenic KrasG12D induces neoplastic transformation of pancreatic acinar cells through acinar-to-ductal metaplasia (ADM), an actin-based morphogenetic process, and drives pancreatic ductal adenocarcinoma (PDAC). mTOR (mechanistic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba34c09707c2496b2d8d168be927eda2
https://hdl.handle.net/10281/396252
https://hdl.handle.net/10281/396252
Autor:
Yamin, Zhao, Benjamin, Schoeps, Dianbo, Yao, Zhiheng, Zhang, Kathleen, Schuck, Vivien, Tissen, Carsten, Jäger, Anna Melissa, Schlitter, Rob, van der Kammen, Christina, Ludwig, Jan G, D'Haese, Susanne, Raulefs, Nadja, Maeritz, Shanshan, Shen, Xiaoping, Zou, Achim, Krüger, Jörg, Kleeff, Christoph W, Michalski, Helmut, Friess, Metello, Innocenti, Bo, Kong
Publikováno v:
Gastroenterology. 160(5)
Oncogenic KrasA mouse model of inflammation-accelerated KrasWe found that mTORC1 and mTORC2 are markedly activated in human and mouse ADM lesions, and cooperate to promote KrasHere, we show that mTORC1 and mTORC2 attain a dual, yet nonredundant regul