Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Vivien Pósa"'
Autor:
Nádia Ribeiro, Ipek Bulut, Baris Sergi, Vivien Pósa, Gabriella Spengler, Giuseppe Sciortino, Vânia André, Liliana P. Ferreira, Tarita Biver, Valeria Ugone, Eugenio Garribba, João Costa-Pessoa, Éva A. Enyedy, Ceyda Acilan, Isabel Correia
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
We report the synthesis and characterization of a group of benzoylhydrazones (Ln) derived from 2-carbaldehyde-8-hydroxyquinoline and benzylhydrazides containing distinct para substituents (R = H, Cl, F, CH3, OCH3, OH and NH2, for L1-7, respectively;
Externí odkaz:
https://doaj.org/article/39d0a688871541ab8b5f628dd3f7dc53
Autor:
Tamás Pivarcsik, Vivien Pósa, Hilda Kovács, Nóra V. May, Gabriella Spengler, Szonja P. Pósa, Szilárd Tóth, Zeinab Nezafat Yazdi, Csilla Özvegy-Laczka, Imre Ugrai, István Szatmári, Gergely Szakács, Éva A. Enyedy
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 593 (2022)
Multidrug resistance (MDR) in cancer is one of the major obstacles of chemotherapy. We have recently identified a series of 8-hydroxyquinoline Mannich base derivatives with MDR-selective toxicity, however with limited solubility. In this work, a nove
Externí odkaz:
https://doaj.org/article/2bf53682947340ca85e032c29c441c22
Autor:
Vivien Pósa, Alessia Stefanelli, Julia H. Bormio Nunes, Sonja Hager, Marlene Mathuber, Nóra V. May, Walter Berger, Bernhard K. Keppler, Christian R. Kowol, Éva A. Enyedy, Petra Heffeter
Publikováno v:
Cancers, Vol 14, Iss 18, p 4455 (2022)
COTI-2 is currently being evaluated in a phase I clinical trial for the treatment of gynecological and other solid cancers. As a thiosemicarbazone, this compound contains an N,N,S-chelating moiety and is, therefore, expected to bind endogenous metal
Externí odkaz:
https://doaj.org/article/3688b614d8fd4e1899b1ede1b72ed230
Triapine Derivatives Act as Copper Delivery Vehicles to Induce Deadly Metal Overload in Cancer Cells
Autor:
Kateryna Ohui, Iryna Stepanenko, Iuliana Besleaga, Maria V. Babak, Radu Stafi, Denisa Darvasiova, Gerald Giester, Vivien Pósa, Eva A. Enyedy, Daniel Vegh, Peter Rapta, Wee Han Ang, Ana Popović-Bijelić, Vladimir B. Arion
Publikováno v:
Biomolecules, Vol 10, Iss 9, p 1336 (2020)
Thiosemicarbazones continue to attract the interest of researchers as potential anticancer drugs. For example, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, or triapine, is the most well-known representative of this class of compounds that has
Externí odkaz:
https://doaj.org/article/f157861451a146cbb48e29d7fa7d856e
Autor:
Petra Heffeter, Sonja Hager, Christian R. Kowol, Alessia Stefanelli, Walter Berger, Éva A. Enyedy, Julia H Bormio Nunes, Alexander Roller, Bernhard K. Keppler, Vivien Pósa, Marlene Mathuber
Publikováno v:
Journal of Medicinal Chemistry
COTI-2 is a novel anticancer thiosemicarbazone in phase I clinical trial. However, the effects of metal complexation (a main characteristic of thiosemicarbazones) and acquired resistance mechanisms are widely unknown. Therefore, in this study, the co
Autor:
Vivien Pósa, Bálint Hajdu, Gábor Tóth, Orsolya Dömötör, Christian R. Kowol, Bernhard K. Keppler, Gabriella Spengler, Béla Gyurcsik, Éva A. Enyedy
Publikováno v:
SSRN Electronic Journal.
Thiosemicarbazones are promising candidates for anticancer therapy and their mechanism of action is often linked to their metal chelating ability. In this study, five (thio)semicarbazones with different donor sets (NNS, NNO, ONS, ONO) were selected a
Autor:
Vivien Pósa, Veronika F.S. Pape, Nikolett Jabronka, Éva A. Enyedy, Bianca Montsch, Lukas Uhlik, Sonja Hager, Bernhard K. Keppler, Szilárd Tóth, Christian R. Kowol, Petra Heffeter, Gergely Szakács
Publikováno v:
Antioxidants & Redox Signaling. 33:395-414
Aims: Due to their significant biological activity, thiosemicarbazones (TSCs) are promising candidates for anticancer therapy. In part, the efficacy of TSCs is linked to their ability to chelate essential metal ions such as copper and iron. Triapine,
Autor:
Nádia Ribeiro, Ipek Bulut, Vivien Pósa, Baris Sergi, Giuseppe Sciortino, João Costa Pessoa, Luisa B. Maia, Valeria Ugone, Eugenio Garribba, Éva A. Enyedy, Ceyda Acilan, Isabel Correia
Publikováno v:
Journal of Inorganic Biochemistry
We report the synthesis and characterization of a family of benzohydrazones (L-n, n = 1-6) derived from 2-car-baldehyde-8-hydroxyquinoline and benzylhydrazides containing different substituents in the para position. Their oxidovanadium(IV) complexes
Publikováno v:
European Journal of Pharmaceutical Sciences. 115:25-36
One of the latest trends is search for the new anti-psychotic drugs among coumarin derivatives with piperazine moiety. Their therapeutic potential can be hampered by poor physico-chemical parameters as low brain penetration or limited transport in th
Autor:
Bernhard K. Keppler, Veronika F.S. Pape, Christian R. Kowol, Éva A. Enyedy, Nikolett Jabronka, Lukas Uhlik, Szilárd Tóth, Walter Berger, Gergely Szakács, Bianca Montsch, Sonja Hager, Vivien Pósa, Petra Heffeter
Publikováno v:
Cancer Research. 80:1939-1939
Triapine, which is currently tested in a clinical phase III trial, is the best-studied thiosemicarbazone (TSC) for anticancer therapy. With regard to the mode of action, anticancer activity of TSCs is frequently linked to their ability to chelate ess