Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Vivien A. Warren"'
Autor:
Nina Jochnowitz, Catherine Abbadie, Clare London, Gregory J. Kaczorowski, Joseph L. Duffy, Birgit T. Priest, Erin McGowan, Kathryn A. Lyons, Maria L. Garcia, Vivien A. Warren, Xiaohua Li, Bindhu V. Karanam, Scott B. Hoyt, Brande Thomas-Fowlkes, John P. Felix, McHardy M. Smith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3640-3645
A series of benzazepinones were synthesized and evaluated for block of Nav1.7 sodium channels. Compound 30 from this series displayed potent channel block, good selectivity versus other targets, and dose-dependent oral efficacy in a rat model of neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7dd437fffdf8a590df11a0f8a3fac9
https://doi.org/10.1016/j.bmcl.2013.03.121
https://doi.org/10.1016/j.bmcl.2013.03.121
Autor:
Stephen P. Arneric, Vivien A. Warren, Joseph L. Duffy, Owen B. McManus, James B Herrington, Clare London, Terrance P. Snutch, Rodolfo Haedo, Randal M. Bugianesi, Gregory J. Kaczorowski, Ge Dai, Cyrus Eduljee, Scott B. Hoyt, David Parker, McHardy M. Smith, Andrew M. Swensen, Kevin S. Ratliff
Publikováno v:
Molecular Pharmacology. 81:488-497
Biological, genetic, and clinical evidence provide validation for N-type calcium channels (Ca V 2.2) as therapeutic targets for chronic pain. A state-dependent Ca V 2.2 inhibitor may provide an improved therapeutic window over ziconotide, the peptidy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec267e20b4e339380c1bc9d081bfad8
https://doi.org/10.1124/mol.111.075226
https://doi.org/10.1124/mol.111.075226
Autor:
Brande S. Williams, Mathew J. Wyvratt, Sriram Tyagarajan, Vivien A. Warren, Catherine Abbadie, Brett Taylor, William J. Martin, Xiaohua Li, William H. Parsons, Nina Jochnowitz, Erin McGowan, Sanjeev Kumar, Ann E. Weber, Gregory J. Kaczorowski, Michael H. Fisher, Bishan Zhou, John P. Felix, Tracy Klatt, McHardy M. Smith, Birgit T. Priest, Prasun K. Chakravarty, Kathryn A. Lyons, Joseph L. Duffy, Ronsar Eid, Maria L. Garcia, Richard M. Brochu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7479-7482
A series of novel biphenyl pyrazole dicarboxamides were identified as potential sodium channel blockers for treatment of neuropathic pain. Compound 20 had outstanding efficacy in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44809e16a6cd04e26b06d5a57716c59e
https://doi.org/10.1016/j.bmcl.2010.10.017
https://doi.org/10.1016/j.bmcl.2010.10.017
Autor:
James B Herrington, Brande S. Williams, Vivien A. Warren, Rodolfo Haedo, Annie Liang, Cyrus Eduljee, D. Euan MacIntyre, Terrance P. Snutch, Clare London, Randal M. Bugianesi, Shruti Mistry, Owen B. McManus, Gregory J. Kaczorowski, Scott B. Hoyt, McHardy M. Smith, Catherine Abbadie, Kathryn A. Lyons, Elizabeth Tringham, Ge Dai, Joseph L. Duffy, Patricia B. Bunting, Andrew M. Swensen, Sylvia Volksdorf, Valerie V. White, Stephen P. Arneric, Shu-Yu Sun, Nina Jochnowitz, Erin McGowan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 334:545-555
Voltage-gated calcium channel (Ca(v))2.2 (N-type calcium channels) are key components in nociceptive transmission pathways. Ziconotide, a state-independent peptide inhibitor of Ca(v)2.2 channels, is efficacious in treating refractory pain but exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd124339b84cf1477ace94a03c0afc3e
https://doi.org/10.1124/jpet.110.166363
https://doi.org/10.1124/jpet.110.166363
Autor:
Alison Rush, James B Herrington, Rodolfo Haedo, Mark E. Williams, Owen B. McManus, McHardy M. Smith, Andrew M. Swensen, Ge Dai, Kevin S. Ratliff, Randal M. Bugianesi, Vivien A. Warren
Publikováno v:
ASSAY and Drug Development Technologies. 6:195-212
Cav2.2 channels play a critical role in pain signaling by controlling synaptic transmission between dorsal root ganglion neurons and dorsal horn neurons. The Cav2.2-selective peptide blocker ziconotide (Prialt, Elan Pharmaceuticals, Dublin, Ireland)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54940784e8ad45d85e6d7baf0b563e61
https://doi.org/10.1089/adt.2008.136
https://doi.org/10.1089/adt.2008.136
Autor:
Matthew J. Wyvratt, Vivien A. Warren, John P. Felix, Maria L. Garcia, Scott B. Hoyt, William H. Parsons, Kathryn A. Lyons, Xiaohua Li, Michael H. Fisher, Clare London, McHardy M. Smith, Birgit T. Priest, Gregory J. Kaczorowski, Doreen E. Cashen, William J. Martin, D. Euan MacIntyre, Brande S. Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1963-1966
A series of 3-amino-1,5-benzodiazepinones were synthesized and evaluated as potential sodium channel blockers in a functional, membrane potential-based assay. One member of this series displayed subnanomolar, state-dependent sodium channel block, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b3b0b1ace18d4deb975e9213b0b5f2
https://doi.org/10.1016/j.bmcl.2008.01.123
https://doi.org/10.1016/j.bmcl.2008.01.123
Autor:
Charles J. Cohen, Margaret Z Chou, Brande S. Williams, Yui S. Tang, Ivy E. Dick, Brita S. Reiseter, Maria L. Garcia, Gregory J. Kaczorowski, Keith A. Wafford, William J. Martin, Samantha Clark, Vivien A. Warren, Peter T. Meinke, Ge Dai, William H. Parsons, Richard E. Middleton, William A. Schmalhofer, Martin Köhler, McHardy M. Smith, Richard M. Brochu, Shao Pengcheng Patrick, Chou J. Liu, Birgit T. Priest, John P. Felix
Publikováno v:
Biochemistry. 43:9866-9876
Sodium channel blockers are used clinically to treat a number of neuropathic pain conditions, but more potent and selective agents should improve on the therapeutic index of currently used drugs. In a high-throughput functional assay, a novel sodium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3ddd47eae5772bd4e88e362138fc4d
https://doi.org/10.1021/bi0493259
https://doi.org/10.1021/bi0493259
Autor:
Vivien A. Warren, Peter T. Meinke, Susan P. Rohrer, Brian R. Petuch, James M. Schaeffer, Gregory J. Kaczorowski, Dennis M. Schmatz, Brande S. Thomas, Eric A. Ertel, Richard M. Brochu, Charles J. Cohen, McHardy M. Smith, Yui Sing Tang
Publikováno v:
Biochemistry. 39:5543-5554
Nodulisporic acid (NA) is an indole diterpene fungal product with insecticidal activity. NA activates a glutamate-gated chloride channel (GluCl) in grasshopper neurons and potentiates channel opening by glutamate. The endectocide ivermectin (IVM) ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3aaa94933a9832a59a739e5642750f6
https://doi.org/10.1021/bi992943i
https://doi.org/10.1021/bi992943i
Autor:
Lois K. Miller, Vivien A. Warren, Jeffrey W. Warmke, McHardy M. Smith, Victor M. Garsky, Grigori G. Prikhod'ko, Charles J. Cohen, Holly J.R. Popham, Thomas J. Felcetto, Dan A. Ostlind
Publikováno v:
Biological Control. 12:66-78
Previously, we have described the properties of recombinant baculoviruses expressing three chimeric genes, mag4, sat2, and ssh1, that encode secretable insect selective sodium channel toxins, μ-Aga-IV from the spider Agelenopsis aperta, As II from t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::820d4dcaf26049eb3b73441d9d7cd587
https://doi.org/10.1006/bcon.1997.0605
https://doi.org/10.1006/bcon.1997.0605
Autor:
Catherine Abbadie, Vivien A. Warren, Xiaohua Li, James B Herrington, Gregory J. Kaczorowski, Shruti Mistry, Feng Ye, Andrew M. Swensen, Prasun K. Chakravarty, Rodolfo Haedo, Kathryn A. Lyons, Owen B. McManus, Randal M. Bugianesi, Mitchell D. Green, Shao Pengcheng Patrick, Maria L. Garcia, Shu-Yu Sun, McHardy M. Smith, Erin McGowan, Nina Jochnowitz, Joseph L. Duffy, Ge Dai
We report the investigation of sulfonamide-derived Cav2.2 inhibitors to address drug-metabolism liabilities with this lead class of analgesics. Modification of the benzamide substituent provided improvements in both potency and selectivity. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a14af3d556993551af77251b7d66937
https://europepmc.org/articles/PMC4027232/
https://europepmc.org/articles/PMC4027232/
