Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Vivianne Malmström"'
Autor:
Fatemeh Moadab, Xiaoxing Wang, Ethan Le, Tal Gazitt, Rayan Najjar, J. Lee Nelson, Vijay Joshua, Vivianne Malmström, Keith Elkon, Caroline Grönwall, Tomas Mustelin
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Anti-citrullinated protein autoantibodies (ACPA) are diagnostic for rheumatoid arthritis (RA). The antigens recognized by these autoantibodies are produced by protein arginine deiminases (PADs), particularly PAD4. However, it remains unknown
Externí odkaz:
https://doaj.org/article/2841507a27d0486f8b838b508e821257
A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis
Autor:
Yibo He, Changrong Ge, Àlex Moreno-Giró, Bingze Xu, Christian M. Beusch, Katalin Sandor, Jie Su, Lei Cheng, Erik Lönnblom, Christina Lundqvist, Linda M. Slot, Dongmei Tong, Vilma Urbonaviciute, Bibo Liang, Taotao Li, Gonzalo Fernandez Lahore, Mike Aoun, Vivianne Malmström, Theo Rispens, Patrik Ernfors, Camilla I. Svensson, Hans Ulrich Scherer, René E. M. Toes, Inger Gjertsson, Olov Ekwall, Roman A. Zubarev, Rikard Holmdahl
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Although elevated levels of anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA), the in vivo functions of these antibodies remain unclear. Here, we have expressed monoclonal ACPAs derived from patients w
Externí odkaz:
https://doaj.org/article/7b376f73d800450f955918dee2fa82ac
Autor:
Uta Hardt, Konstantin Carlberg, Erik af Klint, Peter Sahlström, Ludvig Larsson, Annika van Vollenhoven, Susana Hernandez Machado, Lena Israelsson, Khaled Amara, Karine Chemin, Marina Korotkova, Gunilla B. Karlsson Hedestam, Anca I. Catrina, Sarah A. Teichmann, Patrik L. Ståhl, Vivianne Malmström
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract B cells play a significant role in established Rheumatoid Arthritis (RA). However, it is unclear to what extent differentiated B cells are present in joint tissue already at the onset of disease. Here, we studied synovial biopsies (n = 8) ca
Externí odkaz:
https://doaj.org/article/b11045f7b39d467ebdebe0b878f195cf
Autor:
Alexandra Argyriou, Marc H. Wadsworth, Adrian Lendvai, Stephen M. Christensen, Aase H. Hensvold, Christina Gerstner, Annika van Vollenhoven, Kellie Kravarik, Aaron Winkler, Vivianne Malmström, Karine Chemin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Antibodies against citrullinated proteins (ACPA) can divide rheumatoid arthritis patients but the difference in immune phenotype is not clear. Here the authors characterise T peripheral helper cells in arthritic joints comparing ACPA+ and ACPA- patie
Externí odkaz:
https://doaj.org/article/7c4b331efe744bea9c025a9a5c5433f2
Autor:
Uta Hardt, Martin M. Corcoran, Sanjana Narang, Vivianne Malmström, Leonid Padyukov, Gunilla B. Karlsson Hedestam
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Immunoglobulin heavy chain (IGH) germline gene variations influence the B cell receptor repertoire, with resulting biological consequences such as shaping our response to infections and altering disease susceptibilities. However, the lack of informat
Externí odkaz:
https://doaj.org/article/2e40f5a7e7a942f8a395b4af40f422e8
Autor:
Sanja Vickovic, Denis Schapiro, Konstantin Carlberg, Britta Lötstedt, Ludvig Larsson, Franziska Hildebrandt, Marina Korotkova, Aase H. Hensvold, Anca I. Catrina, Peter K. Sorger, Vivianne Malmström, Aviv Regev, Patrik L. Ståhl
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Sanja Vickovic et al. use spatial transcriptomics to probe the local synovial tissue interactions in rheumatoid arthritis (RA) patients. Their results provide a valuable resource to understand the spatial organisation of cell populations in the synov
Externí odkaz:
https://doaj.org/article/9aa2cc593d9f4b808a9549f5788c0058
Autor:
Ravi K. Sharma, Sanjay V. Boddul, Niyaz Yoosuf, Sara Turcinov, Anatoly Dubnovitsky, Genadiy Kozhukh, Fredrik Wermeling, William W. Kwok, Lars Klareskog, Vivianne Malmström
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract We aimed to search for common features in the autoreactive T cell receptor (TCR) repertoire in patients with rheumatoid arthritis (RA), focusing on the newly identified candidate antigen citrullinated Tenascin C (cit-TNC). Mononuclear cells
Externí odkaz:
https://doaj.org/article/14d145fadcf44f8dbefb370495f5fe23
Autor:
Francesca Faustini, Nicky Dunn, Nastya Kharlamova, Malin Ryner, Annette Bruchfeld, Vivianne Malmström, Anna Fogdell-Hahn, Iva Gunnarsson
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-13 (2021)
Abstract Background Anti-drug antibodies (ADAs) can impact on the efficacy and safety of biologicals, today used to treat several chronic inflammatory conditions. Specific patient groups may be more prone to develop ADAs. Rituximab is routinely used
Externí odkaz:
https://doaj.org/article/b7257dfa012e4aaa8b14f9ea4767b718
Autor:
Alexandra Cîrciumaru, Marcelo Gomes Afonso, Heidi Wähämaa, Akilan Krishnamurthy, Monika Hansson, Linda Mathsson-Alm, Márton Keszei, Ragnhild Stålesen, Lars Ottosson, Charlotte de Vries, Miriam A. Shelef, Vivianne Malmström, Lars Klareskog, Anca I. Catrina, Caroline Grönwall, Aase Hensvold, Bence Réthi
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 630 (2023)
Background: Why the adaptive immune system turns against citrullinated antigens in rheumatoid arthritis (RA) and whether anti-citrullinated protein antibodies (ACPAs) contribute to pathogenesis are questions that have triggered intense research, but
Externí odkaz:
https://doaj.org/article/6999994fcf874f858a310c2f18e72d74
Autor:
Natalia Sherina, Charlotte de Vries, Nastya Kharlamova, Natalie Sippl, Xia Jiang, Boel Brynedal, Elin Kindstedt, Monika Hansson, Linda Mathsson-Alm, Lena Israelsson, Ragnhild Stålesen, Saedis Saevarsdottir, Rikard Holmdahl, Aase Hensvold, Gunnar Johannsen, Kaja Eriksson, Federica Sallusto, Anca I. Catrina, Johan Rönnelid, Caroline Grönwall, Tülay Yucel-Lindberg, Lars Alfredsson, Lars Klareskog, Luca Piccoli, Vivianne Malmström, Khaled Amara, Karin Lundberg
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Based on the epidemiological link between periodontitis and rheumatoid arthritis (RA), and the unique feature of the periodontal bacterium Porphyromonas gingivalis to citrullinate proteins, it has been suggested that production of anti-citrullinated
Externí odkaz:
https://doaj.org/article/526e09f1b5cb4ce898b6e91a70579ed3