Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Viviane S. De Paula"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Here, the authors present Methyl Assignments Using Satisfiability (MAUS), a method for the assignment of methyl groups using raw NOE data. They use eight proteins in the 10–45 kDa size range as test cases and show that MAUS yields 100% accurate ass
Externí odkaz:
https://doaj.org/article/cb22eaddf85f4c9698cd9093fadb2f6b
Autor:
Soumya P. Behera, Abhinav Dubey, Wan-Na Chen, Viviane S. De Paula, Meng Zhang, Nikolaos G. Sgourakis, Wolfgang Bermel, Gerhard Wagner, Paul W. Coote, Haribabu Arthanari
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
The structure and dynamics of large proteins and complexes can be studied by methyl-NMR but resonance assignment is still challenging. Here, the authors present a NMR method that leverages optimal control pulse design to unambiguously distinguish bet
Externí odkaz:
https://doaj.org/article/6d3ce66bd2fb4ffa8c649ac9c398510f
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Methyl-specific isotope labeling is a powerful tool to study the structure, dynamics and interactions of large proteins and protein complexes by solution-state NMR. However, widespread applications of this methodology have been limited by challenges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c0ea72250e8db6f463842b779fac92
https://doaj.org/article/cb22eaddf85f4c9698cd9093fadb2f6b
https://doaj.org/article/cb22eaddf85f4c9698cd9093fadb2f6b
Autor:
Kevin Jude, Viviane S. De Paula, K. Christopher Garcia, Santrupti Nerli, Caleb R. Glassman, Nikolaos G. Sgourakis
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance An extensive body of work has revealed that the conformational plasticity of IL-2 plays an important role in targeting the IL-2 receptor signaling axis in both agonist and antagonist mode; however, a more detailed understanding of such p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdef72cdafd9b8c0d4f64bd18387950d
https://doi.org/10.1073/pnas.2000419117
https://doi.org/10.1073/pnas.2000419117
The Cas9 endonuclease is broadly used for genome engineering applications by programming its single-guide RNA, where high specificity is required. Although mechanistic understanding of DNA cleavage in the CRISPR-Cas9 system has been guided by crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cea30c219bb1567677f6bb111d00416b
https://doi.org/10.1101/2020.12.06.413757
https://doi.org/10.1101/2020.12.06.413757
Autor:
Abhinav Dubey, Wolfgang Bermel, Wan-Na Chen, Nikolaos G. Sgourakis, Meng Zhang, Paul Coote, Soumya P. Behera, Gerhard Wagner, Haribabu Arthanari, Viviane S. De Paula
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Methyl-NMR enables atomic-resolution studies of structure and dynamics of large proteins in solution. However, resonance assignment remains challenging. The problem is to combine existing structural informational with sparse distance restraints and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3117484b083c4280f4389e30a6cdf7f1
https://pubmed.ncbi.nlm.nih.gov/33144564
https://pubmed.ncbi.nlm.nih.gov/33144564
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 13
Interleukin-2 (IL-2) is a small α-helical cytokine that regulates immune cell homeostasis through its recruitment to a high-affinity heterotrimeric receptor complex (IL-2Rα/IL-2Rβ/γc). IL-2 has been shown to have therapeutic efficacy for immune d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b7f25553015a0ba8e2bfd1870ae1c7
https://escholarship.org/uc/item/65v498gf
https://escholarship.org/uc/item/65v498gf
Autor:
Yulia Pustovalova, Irina Bezsonova, Fabio C. L. Almeida, Dmitry M. Korzhnev, Luciana Ferreira Machado, Ana Paula Valente, Viviane S. De Paula
Publikováno v:
Biochemistry. 57:5797-5806
Sugar cane defensin 5 (Sd5) is a small antifungal protein, whose structure is held together by four conserved disulfide bridges. Sd5 and other proteins sharing a cysteine-stabilized α-β (CSαβ) fold lack a regular hydrophobic core. Instead, they a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1310a3e84b5b824b7d469a806a3d91a
https://doi.org/10.1021/acs.biochem.8b00753
https://doi.org/10.1021/acs.biochem.8b00753
Autor:
Santrupti Nerli, Nikolaos G. Sgourakis, Viviane S. De Paula, K. Christopher Garcia, Kevin Jude, Caleb R. Glassman
Publikováno v:
Biophysical Journal. 118:51a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::708474419afa4bcaba4075bda09fc8b8
https://doi.org/10.1016/j.bpj.2019.11.459
https://doi.org/10.1016/j.bpj.2019.11.459
Autor:
Ivo M.B. Francischetti, Robson Q. Monteiro, Ana Paula Valente, Nikolaos G. Sgourakis, Fabio C. L. Almeida, Viviane S. De Paula
Publikováno v:
Blood
Ixolaris is a potent tick salivary anticoagulant that binds coagulation factor Xa (FXa) and zymogen FX, with formation of a quaternary tissue factor (TF)/FVIIa/ FX(a)/Ixolaris inhibitory complex. Ixolaris blocks TF-induced coagulation and PAR2 signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae279a8c84175862c29f5dca8d15ade
https://pubmed.ncbi.nlm.nih.gov/31439616
https://pubmed.ncbi.nlm.nih.gov/31439616