The relationship among sperm global DNA methylation, telomere length, and DNA fragmentation in varicocele: a cross-sectional study of 20 cases

Autor: Maria Aparecida Carneiro Vasconcelos, Rui Alberto Ferriani, Ester Silveira Ramos, Viviane Paiva Santana, Rosana Maria dos Reis, Matheus Credendio Eiras, Rodrigo T. Calado, Sandro C. Esteves, Cristiana Libardi Miranda-Furtado, Daiana Cristina Chielli Pedroso

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Varicocele pathophysiology is related to increased oxidative stress, which might result in loss sperm DNA integrity as well as in genomic instability. Sperm telomere shortening and loss of global DNA methylation are the main features of genomic insta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7182bc564fbb1cfe70f8021b5bd02715
https://doi.org/10.1080/19396368.2018.1557762

Seeking the elusive genes associated with varicocele: a step forward

Autor: Sandro C. Esteves, Viviane Paiva Santana

Publikováno v: Santana, V P & Esteves, S C 2021, ' Seeking the elusive genes associated with varicocele : a step forward ', Fertility and Sterility, vol. 115, no. 2, pp. 313-314 . https://doi.org/10.1016/j.fertnstert.2020.09.128

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48953cb86e49686c3acb2fe4b08eb0b4
https://pubmed.ncbi.nlm.nih.gov/32912637

Differential DNA methylation pattern and sperm quality in men with varicocele

Autor: Sandro C. Esteves, Emma R. James, Cristiana Libardi Miranda-Furtado, Viviane Paiva Santana, Mateus Felipe de Souza, Douglas T. Carrell, Timothy G. Jenkins, Rosana Maria dos Reis, Camila Pinho Pompeu, Kenneth I. Aston

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Objective To study the global DNA methylation pattern in spermatozoa of patients with varicocele as well as investigate their semen quality. Design Prospective observational case-control study. Setting University-affiliated hospital. Patient(s) A tot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec3de00e4fb79139d365a012f1c2e62

Genetics and Epigenetics of Varicocele Pathophysiology

Autor: Viviane Paiva Santana, Cristiana Libardi Miranda-Furtado, Rosana Maria dos Reis

Publikováno v: Varicocele and Male Infertility ISBN: 9783319791012

Varicocele is the main identifiable cause of male infertility. Despite the impairment of spermatogenesis and its associated infertility, not all men with varicocele are infertile or have alterations in semen parameters. Furthermore, varicocele can be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::549ce12bb0cf6213f445ca7c2985394a
https://doi.org/10.1007/978-3-319-79102-9_4

Skewed X-chromosome inactivation and shorter telomeres associate with idiopathic premature ovarian insufficiency

Autor: Ester Silveira Ramos, Rui Alberto Ferriani, Daiana Cristina Chielli Pedroso, Cristiana Libardi Miranda-Furtado, Viviane Paiva Santana, Fernando M. Reis, Cristina Laguna Benetti-Pinto, Mariella A. Maciel, Lisandra Cristina Caetano, Barbara A. Santana, Rodrigo T. Calado, Heloise R. Luchiari, Rosana Maria dos Reis, Gislaine Satyko Kogure

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Objective To analyze whether telomere length, X-chromosome inactivation (XCI), and androgen receptor (AR) GAG polymorphism are related to idiopathic premature ovarian insufficiency (POI). Design Case–control study. Setting University hospital. Pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426344724ad5932caa2e56b946c96bc4