Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Viviane Labrie"'
Autor:
Juozas Gordevicius, Peipei Li, Lee L. Marshall, Bryan A. Killinger, Sean Lang, Elizabeth Ensink, Nathan C. Kuhn, Wei Cui, Nazia Maroof, Roberta Lauria, Christina Rueb, Juliane Siebourg-Polster, Pierre Maliver, Jared Lamp, Irving Vega, Fredric P. Manfredsson, Markus Britschgi, Viviane Labrie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Dysfunction of the gastrointestinal system, and to the autophagy lysososmal pathway (ALP) have been reported in Parkinson’s disease. Here the authors report epigenetic disruption of ALP related genes in the appendix of individuals with Parkinson’
Externí odkaz:
https://doaj.org/article/f9f6d09087434442861f49df6420270e
Autor:
Sangeetha Vishweswaraiah, Sumeyya Akyol, Ali Yilmaz, Zafer Ugur, Juozas Gordevičius, Kyung Joon Oh, Patrik Brundin, Uppala Radhakrishna, Viviane Labrie, Stewart F. Graham
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Parkinson’s disease (PD) is second most prevalent neurodegenerative disorder following Alzheimer’s disease. Parkinson’s disease is hypothesized to be caused by a multifaceted interplay between genetic and environmental factors. Herein, and for
Externí odkaz:
https://doaj.org/article/4e5cb75fdff04f49bba0fcfc9dbc0b47
Autor:
Peipei Li, Elizabeth Ensink, Sean Lang, Lee Marshall, Meghan Schilthuis, Jared Lamp, Irving Vega, Viviane Labrie
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Abstract Background Hemispheric asymmetry in neuronal processes is a fundamental feature of the human brain and drives symptom lateralization in Parkinson’s disease (PD), but its molecular determinants are unknown. Here, we identify divergent epige
Externí odkaz:
https://doaj.org/article/09bfdfda0fb848b6983376e99e49cea9
Autor:
Peipei Li, Lee Marshall, Gabriel Oh, Jennifer L. Jakubowski, Daniel Groot, Yu He, Ting Wang, Arturas Petronis, Viviane Labrie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Epigenetic control of enhancers may contribute to neurological disease. Here the authors carry out genome-wide analysis of DNA methylation in neurons isolated postmortem from patients with Alzheimer’s disease.
Externí odkaz:
https://doaj.org/article/d5670791e46748e5b81b102dfc4bd386
Autor:
Shraddha Pai, Peipei Li, Bryan Killinger, Lee Marshall, Peixin Jia, Ji Liao, Arturas Petronis, Piroska E. Szabó, Viviane Labrie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Dopamine dysregulation is centrally linked to major psychosis. Here, the authors characterise the hypomethylation of an enhancer within the insulin-like growth factor 2 gene in neurons of patients with major psychosis and provide evidence that this e
Externí odkaz:
https://doaj.org/article/92406a1645fa465a86fc451c78740010
Autor:
Gabriel Oh, Karolis Koncevičius, Sasha Ebrahimi, Matthew Carlucci, Daniel Erik Groot, Akhil Nair, Aiping Zhang, Algimantas Kriščiūnas, Edward S. Oh, Viviane Labrie, Albert H. C. Wong, Juozas Gordevičius, Peixin Jia, Miki Susic, Art Petronis
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background Maintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of circadian rhythm may increase risk for malignant, psychiatric, metabolic, and other diseases. Resul
Externí odkaz:
https://doaj.org/article/0bb0cf17ddd74d83b454d4798856c92c
Autor:
Gabriel Oh, Sasha Ebrahimi, Matthew Carlucci, Aiping Zhang, Akhil Nair, Daniel E. Groot, Viviane Labrie, Peixin Jia, Edward S. Oh, Richie H. Jeremian, Miki Susic, Tenjin C. Shrestha, Martin R. Ralph, Juozas Gordevičius, Karolis Koncevičius, Art Petronis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
While epigenetic factors have been implicated in the circadian rhythm, the detection of circadian cytosine modifications has remained elusive. Here the authors identify a large number of epigenetically variable cytosines that show circadian oscillati
Externí odkaz:
https://doaj.org/article/89f9083153cf4657915ee2a746f9e965
Autor:
Peipei Li, Bryan A. Killinger, Elizabeth Ensink, Ian Beddows, Ali Yilmaz, Noah Lubben, Jared Lamp, Meghan Schilthuis, Irving E. Vega, Randy Woltjer, J. Andrew Pospisilik, Patrik Brundin, Lena Brundin, Stewart F. Graham, Viviane Labrie
Publikováno v:
Metabolites, Vol 11, Iss 1, p 29 (2021)
The gut microbiome can impact brain health and is altered in Parkinson’s disease (PD). The vermiform appendix is a lymphoid tissue in the cecum implicated in the storage and regulation of the gut microbiota. We sought to determine whether the appen
Externí odkaz:
https://doaj.org/article/b60cac34011e44b08f4a9fdd5f33b059
Autor:
Shraddha Pai, Shirley Hui, Philipp Weber, Soumil Narayan, Owen Whitley, Peipei Li, Viviane Labrie, Jan Baumbach, Anne L Wheeler, Gary D Bader
Publikováno v:
Cerebral Cortex.
An open challenge in human genetics is to better understand the systems-level impact of genotype variation on developmental cognition. To characterize the genetic underpinnings of peri-adolescent cognition, we performed genotype–phenotype and syste
Autor:
Markus Britschgi, Viviane Labrie, Irving E. Vega, Lee Marshall, Nazia Maroof, Juliane Siebourg-Polster, Nathan C. Kuhn, Peipei Li, Wei Cui, Juozas Gordevičius, Jared Lamp, Sean Lang, Fredric P. Manfredsson, Roberta Lauria, Christina Rueb, Elizabeth Ensink, Bryan A. Killinger, Pierre Maliver
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature communications, Berlin : Nature research, 2021, vol. 12, iss. 1, art. no. 5134, p. [1-18]
Nature Communications
Nature communications, Berlin : Nature research, 2021, vol. 12, iss. 1, art. no. 5134, p. [1-18]
The gastrointestinal tract may be a site of origin for α-synuclein pathology in idiopathic Parkinson’s disease (PD). Disruption of the autophagy-lysosome pathway (ALP) may contribute to α-synuclein aggregation. Here we examined epigenetic alterat