Výsledky vyhledávání - "Viviane Grazielle-Silva"

Akademický článek

Disruption of Active Trans-Sialidase Genes Impairs Egress from Mammalian Host Cells and Generates Highly Attenuated Trypanosoma cruzi Parasites

Autor: Gabriela de A. Burle-Caldas, Nailma S. A. dos Santos, Júlia T. de Castro, Fernanda L. B. Mugge, Viviane Grazielle-Silva, Antônio Edson R. Oliveira, Milton C. A. Pereira, João Luís Reis-Cunha, Anderson Coqueiro dos Santos, Dawidson Assis Gomes, Daniella C. Bartholomeu, Nilmar S. Moretti, Sergio Schenkman, Ricardo T. Gazzinelli, Santuza M. R. Teixeira

Publikováno v: mBio, Vol 13, Iss 1 (2022)

ABSTRACT Trans-sialidases (TS) are unusual enzymes present on the surface of Trypanosoma cruzi, the causative agent of Chagas disease. Encoded by the largest gene family in the T. cruzi genome, only few members of the TS family have catalytic activit

Externí odkaz: https://doaj.org/article/726ccde2ca8642a08b521362024bc308

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Akademický článek

Trypanosoma brucei and Trypanosoma cruzi DNA Mismatch Repair Proteins Act Differently in the Response to DNA Damage Caused by Oxidative Stress

Autor: Viviane Grazielle-Silva, Tehseen Fatima Zeb, Richard Burchmore, Carlos Renato Machado, Richard McCulloch, Santuza M. R. Teixeira

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)

MSH2, associated with MSH3 or MSH6, is a central component of the eukaryotic DNA Mismatch Repair (MMR) pathway responsible for the recognition and correction of base mismatches that occur during DNA replication and recombination. Previous studies hav

Externí odkaz: https://doaj.org/article/62cdf41985e24a529c8e7fd00a1f9173

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Akademický článek

Amastin Knockdown in Leishmania braziliensis Affects Parasite-Macrophage Interaction and Results in Impaired Viability of Intracellular Amastigotes.

Autor: Rita Marcia Cardoso de Paiva, Viviane Grazielle-Silva, Mariana Santos Cardoso, Brenda Naemi Nakagaki, Rondon Pessoa Mendonça-Neto, Adriana Monte Cassiano Canavaci, Normanda Souza Melo, Patrícia Massara Martinelli, Ana Paula Fernandes, Wanderson Duarte daRocha, Santuza M R Teixeira

Publikováno v: PLoS Pathogens, Vol 11, Iss 12, p e1005296 (2015)

Leishmaniasis, a human parasitic disease with manifestations ranging from cutaneous ulcerations to fatal visceral infection, is caused by several Leishmania species. These protozoan parasites replicate as extracellular, flagellated promastigotes in t

Externí odkaz: https://doaj.org/article/17e3c887ae7d437a9bbf8963e9a115c8

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Akademický článek

Distinct Phenotypes Caused by Mutation of MSH2 in Trypanosome Insect and Mammalian Life Cycle Forms Are Associated with Parasite Adaptation to Oxidative Stress.

Autor: Viviane Grazielle-Silva, Tehseen Fatima Zeb, Jason Bolderson, Priscila C Campos, Julia B Miranda, Ceres L Alves, Carlos R Machado, Richard McCulloch, Santuza M R Teixeira

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003870 (2015)

BACKGROUND:DNA repair mechanisms are crucial for maintenance of the genome in all organisms, including parasites where successful infection is dependent both on genomic stability and sequence variation. MSH2 is an early acting, central component of t

Externí odkaz: https://doaj.org/article/bb5b7def7a3c4fb4abd4675659eae563

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A Trypanosoma cruzi zinc finger protein that is implicated in the control of epimastigote-specific gene expression and metacyclogenesis

Autor: Fabiano Sviatopolk-Mirsky Pais, Bruna M. Valente, Fernanda L B Mügge, Antonio Edson R. Oliveira, Wanessa M. Goes, Santuza M. R. Teixeira, Ashton T. Belew, Najib M. El-Sayed, Thais S. Tavares, Viviane Grazielle-Silva, Alessandra A. Guarneri

Publikováno v: Parasitology

Trypanosoma cruzi has three biochemically and morphologically distinct developmental stages that are programmed to rapidly respond to environmental changes the parasite faces during its life cycle. Unlike other eukaryotes, Trypanosomatid genomes cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a178a34352a19deeef119fbf0a854a
https://doi.org/10.1017/s0031182020002176

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Trypanosoma brucei and Trypanosoma cruzi DNA Mismatch Repair Proteins Act Differently in the Response to DNA Damage Caused by Oxidative Stress

Autor: Tehseen Fatima Zeb, Carlos Renato Machado, Santuza M. R. Teixeira, Viviane Grazielle-Silva, Richard Burchmore, Richard McCulloch

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Frontiers in Cellular and Infection Microbiology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c405f25fd114bb1bcc8ef68747e922ff
https://www.frontiersin.org/article/10.3389/fcimb.2020.00154/full

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