A Rasch Analysis of the Charcot-Marie-Tooth Neuropathy Score (CMTNS) in a Cohort of Charcot-Marie-Tooth Type 1A Patients.

Autor: Wenjia Wang, Mickaël Guedj, Viviane Bertrand, Julie Foucquier, Elisabeth Jouve, Daniel Commenges, Cécile Proust-Lima, Niall P Murphy, Olivier Blin, Laurent Magy, Daniel Cohen, Shahram Attarian

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0169878 (2017)

The Charcot-Marie-Tooth Neuropathy Score (CMTNS) was developed as a main efficacy endpoint for application in clinical trials of Charcot-Marie-Tooth disease type 1A (CMT1A). However, the sensitivity of the CMTNS for measuring disease severity and pro

Externí odkaz: https://doaj.org/article/1ed5e395f7894e9c845085b6ded2e1f7

P1‐061: DOUBLE‐BLIND ARGUMENT FOR A SYNERGISTIC THERAPEUTIC EFFECT OF A FIXED LOW‐DOSE COMBINATION OF ACAMPROSATE AND BACLOFEN IN ALZHEIMER'S DISEASE

Autor: Daniel Cohen, Peter Schmidt, Jacques Touchon, Serguei Nabirotchkin, Robert Philippe, Rene Goedkoop, Sophie Auriacombe, Jacques Hugon, Mickaël Guedj, Jean-Marc Orgogozo, Rodolphe Hajj, Viviane Bertrand, Florence Pasquier, Pierre Jean Ousset, Claude Guériot

Publikováno v: Alzheimer's & Dementia. 14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::212103d47378e0894a51110725a5ecdd
https://doi.org/10.1016/j.jalz.2018.06.063

Combining two repurposed drugs as a promising approach for Alzheimer's disease therapy

Autor: Emmanuel Vial, Damien Toulorge, Nathalie Cholet, Yannick Pereira, Rémy Steinschneider, Esther Graudens, Tangui Maurice, Julie Foucquier, Rodolphe Hajj, Ilya Chumakov, Serguei Nabirotchkin, Aude Milet, Daniel Cohen, Catherine Scart-Grès, Aurélie Boucard, Noelle Callizot, Mickaël Guedj, Sory Traoré, Viviane Bertrand

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2015, 5 (1), ⟨10.1038/srep07608⟩
Scientific Reports, 2015, 5 (1), ⟨10.1038/srep07608⟩

Alzheimer disease (AD) represents a major medical problem where mono-therapeutic interventions demonstrated only a limited efficacy so far. We explored the possibility of developing a combinational therapy that might prevent the degradation of neuron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97b170dd001135da9749208d50aa097
https://hal.archives-ouvertes.fr/hal-01922611

Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy

Autor: Yannick Pereira, Julien Laffaire, Gwenaël Primas, Emmanuel Vial, Jonas Mandel, Serguei Nabirotchkin, Aude Milet, Esther Graudens, Mickaël Guedj, Fabrice Glibert, Ilya Chumakov, Julie Foucquier, Michael W. Sereda, Daniel Cohen, Nathalie Cholet, Klaus-Armin Nave, Aurélie Boucard, Rodolphe Hajj, Viviane Bertrand

Publikováno v: Orphanet Journal of Rare Diseases

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited sensory and motor peripheral neuropathy. It is caused by PMP22 overexpression which leads to defects of peripheral myelination, loss of long axons, and progressive impairment th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93103b85734e265012438f4aaacfa7ed
http://europepmc.org/articles/PMC4279797

Distal deletion of 1p in colorectal tumors

Autor: Viviane Bertrand, Daniel Couturier, Marie-Hélène Couturier-Turpin

Publikováno v: Cancer Genetics and Cytogenetics. 124:47-55

Cytogenetics studies have suggested that short arm deletion in chromosome 1 is involved in triggering colorectal tumor development. To elucidate the role of 1p under-representation in the tumoral process, we investigated by fluorescence in situ hybri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7e6dd923a8d40eff89ecab4a2525dc5
https://doi.org/10.1016/s0165-4608(00)00325-3