Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Viviana I. Pérez"'
Autor:
Natalia Díaz-Valdivia, Layla Simón, Jorge Díaz, Samuel Martinez-Meza, Pamela Contreras, Renato Burgos-Ravanal, Viviana I. Pérez, Balz Frei, Lisette Leyton, Andrew F. G. Quest
Publikováno v:
Cancers; Volume 14; Issue 12; Pages: 2862
Cancer cells often display impaired mitochondrial function, reduced oxidative phosphorylation, and augmented aerobic glycolysis (Warburg effect) to fulfill their bioenergetic and biosynthetic needs. Caveolin-1 (CAV1) is a scaffolding protein that pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0196987ffecee5e9f6326da971803ed9
Autor:
Bharath Sunchu, Viviana I. Pérez, Andrew C. Drake, Jovita Dimas-Munoz, Ido Almog, Ruben T. Riordan, Zhen Yu
Publikováno v:
J Gerontol A Biol Sci Med Sci
The capacity of cells to maintain proteostasis declines with age, causing rapid accumulation of damaged proteins and protein aggregates, which plays an important role in age-related disease etiology. While our group and others have identified that pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a269b18b2d5f9008ea3f7798076095
https://doi.org/10.1093/gerona/glaa069
https://doi.org/10.1093/gerona/glaa069
Autor:
Lisette Leyton, Balz Frei, Pamela Contreras, Viviana I. Pérez, Renato Burgos-Ravanal, Jorge Díaz, Andrew F. G. Quest, Natalia Diaz-Valdivia, Vicente A. Torres, Victoria Rojas-Celis, Lorena Lobos-González, America Campos
Publikováno v:
Oncogene
Caveolin-1 (CAV1) enhanced migration, invasion, and metastasis of cancer cells is inhibited by co-expression of the glycoprotein E-cadherin. Although the two proteins form a multiprotein complex that includes β-catenin, it remained unclear how this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6787aac69048020a263f9b95c6dcc1
http://europepmc.org/articles/PMC7190567
http://europepmc.org/articles/PMC7190567
Autor:
Wilson C Fok, Yidong Chen, Alex Bokov, Yiqiang Zhang, Adam B Salmon, Vivian Diaz, Martin Javors, William H Wood, Yongqing Zhang, Kevin G Becker, Viviana I Pérez, Arlan Richardson
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83988 (2014)
Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways th
Externí odkaz:
https://doaj.org/article/b87bcfcb78e646c3b77649ae5180f55d
Autor:
Viviana I. Pérez, Rong Wang
Publikováno v:
Nrf2 and its Modulation in Inflammation ISBN: 9783030445973
Inflammation is a common feature of chronic age-related diseases. Therefore, controlling inflammation by manipulation in the molecular mechanisms that cause the inflammatory process becomes critical to improve human health by preventing various disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8be3b6421d56edf5b0257b953a7e6d4d
https://doi.org/10.1007/978-3-030-44599-7_1
https://doi.org/10.1007/978-3-030-44599-7_1
Autor:
Armando Luna-López, Viviana I. Pérez, Claudio Torres, Roxana Rodríguez-Barrera, Jorge Antonio García-Álvarez, Sandra Lizbeth Morales-Rosales, Alejandro Silva-Palacios, Luis Ángel Maciel-Barón, Mina Königsberg
Publikováno v:
Biogerontology. 19:415-433
In the central nervous system (CNS), senescent astrocytes have been associated with neurodegeneration. Senescent cells secrete a complex mixture of pro-inflammatory factors, which are collectively called Senescence Associated Secretory Phenotype (SAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c8c120b3286b118ab2f0b1cde70d01
https://doi.org/10.1007/s10522-018-9767-3
https://doi.org/10.1007/s10522-018-9767-3
Autor:
Dawn A. Olson, Rong Wang, Adam J. Branscum, Zhen Yu, Ruben T. Riordan, Allan M. Aguirre-Burk, Russell T. Turner, Carmen P. Wong, Viviana I. Pérez, Stephen A. Martin, Urszula T. Iwaniec
Publikováno v:
Experimental Gerontology. 154:111516
Advanced age is the strongest risk factor for osteoporosis. The immunomodulator drug rapamycin extends lifespan in numerous experimental model organisms and is being investigated as a potential therapeutic to slow human aging, but little is known abo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432ecdb9eea8875d2e36b888f9f10a88
https://doi.org/10.1016/j.exger.2021.111516
https://doi.org/10.1016/j.exger.2021.111516
Autor:
Yuji Ikeno, Michael E. Walsh, Alex Bokov, Holly Van Remmen, Yuhong Liu, Arlan Richardson, Yiqiang Zhang, Young C. Jang, Viviana I. Pérez
Publikováno v:
Mechanisms of Ageing and Development. 154:1-8
Genetic ablation of CuZn-superoxide dismutase (Sod1) in mice (Sod1(-/-) mice) leads to shortened lifespan with a dramatic increase in hepatocellular carcinoma and accelerated aging phenotypes, including early onset sarcopenia. To study the tissue spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6ce3b410e5c2f332e30e1ab6c6f1d5
https://doi.org/10.1016/j.mad.2016.01.005
https://doi.org/10.1016/j.mad.2016.01.005
Autor:
Stacy A. Hussong, Andy Q. Banh, Candice E. Van Skike, Angela O. Dorigatti, Stephen F. Hernandez, Matthew J. Hart, Beatriz Ferran, Haneen Makhlouf, Maria Gaczynska, Pawel A. Osmulski, Salome A. McAllen, Kelly T. Dineley, Zoltan Ungvari, Viviana I. Perez, Rakez Kayed, Veronica Galvan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Vascular mechanisms of Alzheimer’s disease (AD) may constitute a therapeutically addressable biological pathway underlying dementia. We previously demonstrated that soluble pathogenic forms of tau (tau oligomers) accumulate in brain microv
Externí odkaz:
https://doaj.org/article/a5155c1e3b244cd383da055394ad656e
Autor:
Alexander Coles, Zhen Yu, Jillian Mochnick, Rochelle Buffenstein, Harrison Pride, Viviana I. Pérez, Peter J. Hornsby, Bharath Sunchu, Yiqiang Zhang, Steven N. Austad
Publikováno v:
Biochemical and Biophysical Research Communications. 457:669-675
Our previous studies have shown that the liver from Naked Mole Rats (NMRs), a long-lived rodent, has increased proteasome activity and lower levels of protein ubiquitination compared to mice. This suggests that protein quality control might play a ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148b9f65f34be25d57a731bbc346f7d9
https://doi.org/10.1016/j.bbrc.2015.01.046
https://doi.org/10.1016/j.bbrc.2015.01.046