Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Viviana I Pérez"'
Autor:
Wilson C Fok, Yidong Chen, Alex Bokov, Yiqiang Zhang, Adam B Salmon, Vivian Diaz, Martin Javors, William H Wood, Yongqing Zhang, Kevin G Becker, Viviana I Pérez, Arlan Richardson
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83988 (2014)
Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways th
Externí odkaz:
https://doaj.org/article/b87bcfcb78e646c3b77649ae5180f55d
Autor:
Natalia Díaz-Valdivia, Layla Simón, Jorge Díaz, Samuel Martinez-Meza, Pamela Contreras, Renato Burgos-Ravanal, Viviana I. Pérez, Balz Frei, Lisette Leyton, Andrew F. G. Quest
Publikováno v:
Cancers; Volume 14; Issue 12; Pages: 2862
Cancer cells often display impaired mitochondrial function, reduced oxidative phosphorylation, and augmented aerobic glycolysis (Warburg effect) to fulfill their bioenergetic and biosynthetic needs. Caveolin-1 (CAV1) is a scaffolding protein that pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0196987ffecee5e9f6326da971803ed9
Autor:
Bharath Sunchu, Viviana I. Pérez, Andrew C. Drake, Jovita Dimas-Munoz, Ido Almog, Ruben T. Riordan, Zhen Yu
Publikováno v:
J Gerontol A Biol Sci Med Sci
The capacity of cells to maintain proteostasis declines with age, causing rapid accumulation of damaged proteins and protein aggregates, which plays an important role in age-related disease etiology. While our group and others have identified that pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a269b18b2d5f9008ea3f7798076095
https://doi.org/10.1093/gerona/glaa069
https://doi.org/10.1093/gerona/glaa069
Autor:
Lisette Leyton, Balz Frei, Pamela Contreras, Viviana I. Pérez, Renato Burgos-Ravanal, Jorge Díaz, Andrew F. G. Quest, Natalia Diaz-Valdivia, Vicente A. Torres, Victoria Rojas-Celis, Lorena Lobos-González, America Campos
Publikováno v:
Oncogene
Caveolin-1 (CAV1) enhanced migration, invasion, and metastasis of cancer cells is inhibited by co-expression of the glycoprotein E-cadherin. Although the two proteins form a multiprotein complex that includes β-catenin, it remained unclear how this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6787aac69048020a263f9b95c6dcc1
http://europepmc.org/articles/PMC7190567
http://europepmc.org/articles/PMC7190567
Autor:
Viviana I. Pérez, Rong Wang
Publikováno v:
Nrf2 and its Modulation in Inflammation ISBN: 9783030445973
Inflammation is a common feature of chronic age-related diseases. Therefore, controlling inflammation by manipulation in the molecular mechanisms that cause the inflammatory process becomes critical to improve human health by preventing various disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8be3b6421d56edf5b0257b953a7e6d4d
https://doi.org/10.1007/978-3-030-44599-7_1
https://doi.org/10.1007/978-3-030-44599-7_1
Autor:
Armando Luna-López, Viviana I. Pérez, Claudio Torres, Roxana Rodríguez-Barrera, Jorge Antonio García-Álvarez, Sandra Lizbeth Morales-Rosales, Alejandro Silva-Palacios, Luis Ángel Maciel-Barón, Mina Königsberg
Publikováno v:
Biogerontology. 19:415-433
In the central nervous system (CNS), senescent astrocytes have been associated with neurodegeneration. Senescent cells secrete a complex mixture of pro-inflammatory factors, which are collectively called Senescence Associated Secretory Phenotype (SAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c8c120b3286b118ab2f0b1cde70d01
https://doi.org/10.1007/s10522-018-9767-3
https://doi.org/10.1007/s10522-018-9767-3
Autor:
Dawn A. Olson, Rong Wang, Adam J. Branscum, Zhen Yu, Ruben T. Riordan, Allan M. Aguirre-Burk, Russell T. Turner, Carmen P. Wong, Viviana I. Pérez, Stephen A. Martin, Urszula T. Iwaniec
Publikováno v:
Experimental Gerontology. 154:111516
Advanced age is the strongest risk factor for osteoporosis. The immunomodulator drug rapamycin extends lifespan in numerous experimental model organisms and is being investigated as a potential therapeutic to slow human aging, but little is known abo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432ecdb9eea8875d2e36b888f9f10a88
https://doi.org/10.1016/j.exger.2021.111516
https://doi.org/10.1016/j.exger.2021.111516
Autor:
Yuji Ikeno, Michael E. Walsh, Alex Bokov, Holly Van Remmen, Yuhong Liu, Arlan Richardson, Yiqiang Zhang, Young C. Jang, Viviana I. Pérez
Publikováno v:
Mechanisms of Ageing and Development. 154:1-8
Genetic ablation of CuZn-superoxide dismutase (Sod1) in mice (Sod1(-/-) mice) leads to shortened lifespan with a dramatic increase in hepatocellular carcinoma and accelerated aging phenotypes, including early onset sarcopenia. To study the tissue spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6ce3b410e5c2f332e30e1ab6c6f1d5
https://doi.org/10.1016/j.mad.2016.01.005
https://doi.org/10.1016/j.mad.2016.01.005
Autor:
Alexander Coles, Zhen Yu, Jillian Mochnick, Rochelle Buffenstein, Harrison Pride, Viviana I. Pérez, Peter J. Hornsby, Bharath Sunchu, Yiqiang Zhang, Steven N. Austad
Publikováno v:
Biochemical and Biophysical Research Communications. 457:669-675
Our previous studies have shown that the liver from Naked Mole Rats (NMRs), a long-lived rodent, has increased proteasome activity and lower levels of protein ubiquitination compared to mice. This suggests that protein quality control might play a ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148b9f65f34be25d57a731bbc346f7d9
https://doi.org/10.1016/j.bbrc.2015.01.046
https://doi.org/10.1016/j.bbrc.2015.01.046
Autor:
Luis Ángel, Maciel-Barón, Viviana I, Pérez, Carmen, Torres, Viridiana Y, González-Puertos, Mina, Konigsberg, Norma Edith, López-Diazguerrero
Publikováno v:
Revista medica del Instituto Mexicano del Seguro Social. 55(4)
Cellular senescence has been traditionally characterized by cell cycle arrest of pot-mitotic cells as a response to a cellular damage. Now is known that senescent cells secret a diverse array of cytokines, chemokines, growth factors and other that al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6cdaca9589de07995f9117367cdcb1a5
https://pubmed.ncbi.nlm.nih.gov/28591504
https://pubmed.ncbi.nlm.nih.gov/28591504