Enhancing structural diversity through chemical engineering of Ambrosia tenuifolia extract for novel anti-glioblastoma compounds

Autor: Tonino G. Adessi, Paula M. Wagner, Fabricio R. Bisogno, Viviana E. Nicotra, Mario E. Guido, Manuela E. García

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract Natural products are an unsurpassed source of leading structures in drug discovery. The biosynthetic machinery of the producing organism offers an important source for modifying complex natural products, leading to analogs that are unattaina

Externí odkaz: https://doaj.org/article/c8d319c9433946028c34d5f37cd71e49

New Withanolides from Two Varieties of Jaborosa Caulescens

Autor: Gerardo Burton, Juan C. Oberti, Roberto R. Gil, Viviana E. Nicotra

Publikováno v: Molecules, Vol 5, Iss 3, Pp 514-515 (2000)

The phytochemical study of two species of Jaborosa caulescens (var. caulescens and var. bipinnatifida) yielded the four new withanolides 1-4. The structures of the new compounds were determined using a combination of spectroscopic techniques (includi

Externí odkaz: https://doaj.org/article/01f117a8cf05416998866be3deeae7dd

Late‐stage Rh(II)‐catalyzed Nitrene Transfer for the Synthesis of Guaianolide Analogs with Enhanced Antiproliferative Activity

Autor: Philippe Dauban, Viviana E. Nicotra, Benjamin Darses, José M. Padrón, Sebastián J Castro

Publikováno v: European Journal of Organic Chemistry
European Journal of Organic Chemistry, Wiley-VCH Verlag, 2021, 2021 (12), pp.1859-1863. ⟨10.1002/ejoc.202100074⟩
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Consejo Nacional de Investigaciones Científicas y Técnicas
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A set of new guaianolide derivatives (1–9) was obtained from ludartin, achalensolide, and 11,13-dihydroachalensolide by application of catalytic nitrene transfer reactions. Intermolecular nitrene C(sp3)−H insertions led to the amination of C-1, C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27617c7d421a19843e9003dc6838879f
https://doi.org/10.1002/ejoc.202100074

Psilostachyins as trypanocidal compounds: Bioguided fractionation of Ambrosia tenuifolia chemically modified extract

Autor: Yamile Ana, Mónica C. García, Manuela E. García, Tonino G. Adessi, Viviana E. Nicotra, Fabricio R. Bisogno, Cinthia C. Stempin

Publikováno v: Phytochemistry. 194

This work focusses on the chemical diversification of an Ambrosia tenuifolia extract and its bioguided fractionation, aiming to unveil the chemical entity responsible for the trypanocidal activity. Besides, a revision of the phytochemical study of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2b9d01ff75c3ccebb3ba0109aeada6
https://pubmed.ncbi.nlm.nih.gov/34798411

Withanolides from the genus Exodeconus (Solanaceae). Chemotaxonomical considerations

Autor: Gloria Estela Barboza, Carina Noelia Casero, Viviana E. Nicotra, Adriana Pacciaroni, Fátima Gutiérrez Nicolás, Segundo Leiva González

Five Exodeconus species were phytochemically analyzed. From the aerial parts of E. pusillus, the 7α,27-dihydroxy-1-oxo-22R-witha-2,5,24-trienolide and three other previously unreported normal-type withanolides were isolated. All the studied species

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8b90a4df2e9ddb670fcd47f4991db1
https://linkinghub.elsevier.com/retrieve/pii/S0039128X20301264