Regulation of multidrug resistance proteins by genistein in a hepatocarcinoma cell line: impact on sorafenib cytotoxicity.

Autor: Juan Pablo Rigalli, Nadia Ciriaci, Agostina Arias, María Paula Ceballos, Silvina Stella Maris Villanueva, Marcelo Gabriel Luquita, Aldo Domingo Mottino, Carolina Inés Ghanem, Viviana Alicia Catania, María Laura Ruiz

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119502 (2015)

Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide. Sorafenib is the only drug available that improves the overall survival of HCC patients. P-glycoprotein (P-gp), Multidrug resistance-associated proteins 2 and 3 (MRP2 and 3)

Externí odkaz: https://doaj.org/article/f67cc32f5d164bbe83f394190ac70a9b

Induction of P-glycoprotein expression and activity by prolactin in female rat liver

Autor: Daniel E. Francés, María L. Ruiz, Marcelo G. Luquita, M.G. Sedlmeier, Juan Pablo Rigalli, María Teresa Ronco, Mariana Semeniuk, Viviana A. Catania, Lucila Inés Ceré

Publikováno v: Life Sciences, 287

Contains fulltext : 244825.pdf (Publisher’s version ) (Closed access) AIM: P-glycoprotein (P-gp) plays a critical role in the excretion of xenobiotics into bile. Previous studies have demonstrated that prolactin (PRL) regulates biotransformation an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27df619ec10c77427b19454d5bb3485
https://hdl.handle.net/2066/244825

Regulation of hepatic P-gp expression and activity by genistein in rats

Autor: M. Bucci-Muñoz, María Laura Ruiz, Mariana Semeniuk, Silvina Stella Maris Villanueva, Nadia Ciriaci, Aldo D. Mottino, Viviana A. Catania, Lucila Inés Ceré, Juan Pablo Rigalli

Publikováno v: Archives of Toxicology, 94, 5, pp. 1625-1635
Archives of Toxicology, 94, 1625-1635

Contains fulltext : 220963.pdf (Publisher’s version ) (Closed access) P-glycoprotein (P-gp) is an ABC transporter exhibiting high pharmacotoxicological relevance by extruding a wide range of cytotoxic compounds out of the cells. Previously, we demo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff9de0b63baf6c340440d9e064fd655
https://hdl.handle.net/2066/220963

Benznidazole, the trypanocidal drug used for Chagas disease, induces hepatic NRF2 activation and attenuates the inflammatory response in a murine model of sepsis

Autor: Flavia Lambertucci, Paloma Martín-Sanz, María Teresa Ronco, Daniel E. Francés, María de Luján Alvarez, Omar Motiño, Juan Pablo Rigalli, Ariel D. Quiroga, Viviana A. Catania, Silvina R. Villar, Cristina E. Carnovale

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Molecular mechanisms on sepsis progression are linked to the imbalance between reactive oxygen species (ROS) production and cellular antioxidant capacity. Previous studies demonstrated that benznidazole (BZL), known for its antiparasitic action on Tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98632badc3c574d91b0388fdda446527
https://doi.org/10.1016/j.taap.2016.11.015

Up-regulation of ATP-binding cassette transporters in the THP-1 human macrophage cell line by the antichagasic benznidazole

Autor: Virginia Gabriela Perdomo, Marcelo G. Luquita, María Laura Ruiz, Viviana A. Catania, José M. Pellegrino, Juan Pablo Rigalli

Publikováno v: Memórias do Instituto Oswaldo Cruz
Memórias do Instituto Oswaldo Cruz, Volume: 111, Issue: 11, Pages: 707-711, Published: 24 OCT 2016
Memórias do Instituto Oswaldo Cruz., Vol 111, Iss 11, Pp 707-711

The effect of benznidazole (BZL) on the expression and activity of P-glycoprotein (P-gp, ABCB1) and multidrug resistance-associated protein 2 (MRP2, ABCC2), the two major transporters of endogenous and exogenous compounds, was evaluated in differenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48bf924ed571757756c6531222d3393
http://europepmc.org/articles/PMC5125048