Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Viviana, Marzaioli"'
Autor:
Sinead Harney, Tim O'Sullivan, Douglas J. Veale, Arthritis Ireland, Ursula Fearon, Mary Canavan, Viviana Marzaioli, Siobhan Wade, Alexander Fraser, Alex Donnelly
Publikováno v:
HRB Open Research, Vol 4 (2023)
Background: Patient engagement with clinicians results in shared decision making and increased adherence to medication. However, in order for strong patient: clinician partnerships to be achieved, communication barriers need to be identified. Therefo
Externí odkaz:
https://doaj.org/article/902d5cf4549d459d8f436fe7d79aed3e
Autor:
Brianne E. Barker, Megan M. Hanlon, Viviana Marzaioli, Conor M. Smith, Clare C. Cunningham, Jean M. Fletcher, Douglas J. Veale, Ursula Fearon, Mary Canavan
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
ObjectivesThe mammalian target of Rapamycin (mTOR) is a metabolic master regulator of both innate and adaptive immunity; however, its exact role in stromal cell biology is unknown. In this study we explored the role of the mTOR pathway on Rheumatoid
Externí odkaz:
https://doaj.org/article/0e55b94f1a6145e8b76fc1a644bfe9b2
Autor:
Achilleas Floudas, Aine Gorman, Nuno Neto, Michael G. Monaghan, Zoe Elliott, Ursula Fearon, Viviana Marzaioli
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Inflammatory arthritis is a chronic systemic autoimmune disease of unknown etiology, which affects the joints. If untreated, these diseases can have a detrimental effect on the patient's quality of life, leading to disabilities, and therefore, exhibi
Externí odkaz:
https://doaj.org/article/ff3218653d654c61a221dcee21eb411e
Autor:
Viviana Marzaioli, Mary Canavan, Achilleas Floudas, Keelin Flynn, Ronan Mullan, Douglas J. Veale, Ursula Fearon
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Dendritic cells (DC) have a key role in the initiation and progression of inflammatory arthritis (IA). In this study, we identified a DC population that derive from monocytes, characterized as CD209/CD14+ DC, expressing classical DC markers (HLADR, C
Externí odkaz:
https://doaj.org/article/f2d3cf08d5d045468511d49074c3fd24
Autor:
Mary Canavan, Viviana Marzaioli, Vipul Bhargava, Sunil Nagpal, Phil Gallagher, Conor Hurson, Ronan Mullan, Douglas J. Veale, Ursula Fearon
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
ObjectiveTo examine the role of synovial CD1c+DCs in patients with Inflammatory Arthritis (IA) with a specific focus on the transcriptional and maturation signatures that govern their function.MethodsRNA sequencing was performed on healthy control (H
Externí odkaz:
https://doaj.org/article/71c0a64c744d457b9582855f3937bb8d
Targeting JAK-STAT Signalling Alters PsA Synovial Fibroblast Pro-Inflammatory and Metabolic Function
Autor:
Aisling O’Brien, Megan Mary Hanlon, Viviana Marzaioli, Siobhan C. Wade, Keelin Flynn, Ursula Fearon, Douglas J. Veale
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
ObjectivesPsoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis. Janus Kinase inhibitors (JAKi) have emerged as an encouraging class of drugs for the treatment of PsA. Here, we compare the effect of four JAKi on primar
Externí odkaz:
https://doaj.org/article/d6653fec4c3b4650bfc9bbc9e205e170
Publikováno v:
Pharmaceutical Biology, Vol 57, Iss 1, Pp 55-63 (2019)
Context: Syzygium aromaticum (L.) Merr. & Perry (Myrtaceae), commonly known as clove, originally found in the Muluku Islands in East Indonesia, is widely used as a spice and has numerous medicinal properties. Objective: This study investigated the an
Externí odkaz:
https://doaj.org/article/da0d67964c4b47a597c0369fe7b900a3
Autor:
Achilleas Floudas, Nuno Neto, Viviana Marzaioli, Kieran Murray, Barry Moran, Michael G. Monaghan, Candice Low, Ronan H. Mullan, Navin Rao, Vinod Krishna, Sunil Nagpal, Douglas J. Veale, Ursula Fearon
Publikováno v:
JCI Insight, Vol 5, Iss 21 (2020)
While autoantibodies are used in the diagnosis of rheumatoid arthritis (RA), the function of B cells in the inflamed joint remains elusive. Extensive flow cytometric characterization and SPICE algorithm analyses of single-cell synovial tissue from pa
Externí odkaz:
https://doaj.org/article/84eac101717343a58bf6b2f685169e06
Autor:
Viviana Marzaioli, Mary Canavan, Achilleas Floudas, Siobhan C. Wade, Candice Low, Douglas J. Veale, Ursula Fearon
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Monocyte-derived Dendritic cells (Mo-DC) are a distinct DC subset, involved in inflammation and infection, they originate from monocytes upon stimulation in the circulation and their activation and function may vary in autoimmune diseases. In this st
Externí odkaz:
https://doaj.org/article/155d81e54d094abe949e2f458b97e3d7
Autor:
Sahra Amel Belambri, Viviana Marzaioli, Margarita Hurtado-Nedelec, Coralie Pintard, Shiyu Liang, Yezhou Liu, Tarek Boussetta, Marie-Anne Gougerot-Pocidalo, Richard D. Ye, Pham My-Chan Dang, Jamel El-Benna
Publikováno v:
Blood. 139:2512-2522
Superoxide production by the phagocyte reduced NAD phosphate (NADPH) oxidase is essential for innate immunity as shown in chronic granulomatous disease (CGD), an immunodeficiency disease resulting from mutations in 1 of its genes. The NADPH oxidase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0b343ebd6dade70fdc74ac8b76eba6
https://doi.org/10.1182/blood.2021011134
https://doi.org/10.1182/blood.2021011134