Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Viviana, De Luca"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
This study refers to the intricate world of Acinetobacter baumannii, a resilient pathogenic bacterium notorious for its propensity at antibiotic resistance in nosocomial infections. Expanding upon previous findings that emphasised the bifunctional en
Externí odkaz:
https://doaj.org/article/2695134eb484442e93e679573d836733
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Toxoplasmosis, induced by the intracellular parasite Toxoplasma gondii, holds considerable implications for global health. While treatment options primarily focusing on folate pathway enzymes have notable limitations, current research endeavours conc
Externí odkaz:
https://doaj.org/article/f91536a23fc84dd687c7b04590f9c026
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
The γ-carbonic anhydrase (CA, EC 4.2.1.1) from the pathogenic bacterium, Mammaliicoccus (Staphylococcus) sciuri (MscCAγ) was recently cloned and purified by our groups. Here we investigated inhibition of this enzyme with (in)organic simple and comp
Externí odkaz:
https://doaj.org/article/37083c9acd3742bf945bb361909dda21
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
A small library of novel thiazolone-benzenesulphonamides has been prepared and evaluated for their ability to inhibit three human cytosolic carbonic anhydrases (hCA I, hCA II, and hCA VII) and three bacterial carbonic anhydrases (MscCAβ, StCA1, and
Externí odkaz:
https://doaj.org/article/78761aff2ac64346a46d67d671031268
Autor:
Viviana De Luca, Andrea Angeli, Alessio Nocentini, Paola Gratteri, Silvia Pratesi, Damiano Tanini, Vincenzo Carginale, Antonella Capperucci, Claudiu T. Supuran, Clemente Capasso
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 971 (2024)
The implementation of innovative approaches is crucial in an ongoing endeavor to mitigate the impact of COVID-19 pandemic. The present study examines the strategic application of the SARS-CoV-2 Main Protease (Mpro) as a prospective instrument in the
Externí odkaz:
https://doaj.org/article/b3acc9c8f6664737adbe3c121f289e9c
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2092-2098 (2022)
Carbonic anhydrases, catalysing the reversible CO2 hydration reaction, contribute in all living organisms to the maintenance of stable metabolic functions depending on intracellular concentrations of carbon dioxide, bicarbonate, and protons. Recent s
Externí odkaz:
https://doaj.org/article/c24a82beb06d4e3fbdd07d88c98bb8a8
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 680-685 (2022)
Coumarins were discovered to act as inhibitors of α-carbonic anhydrases (CAs, EC 4.2.1.1) after undergoing hydrolysis mediated by the esterase activity of the enzyme to the corresponding 2-hydroxycinnamic acids. Other classes of CAs among the eight
Externí odkaz:
https://doaj.org/article/147989acf6304c66964b6afec2088733
Autor:
Giulia Nannini, Viviana De Luca, Chiara D’Ambrosio, Andrea Scaloni, Antonio Taddei, Maria Novella Ringressi, Fabio Cianchi, Fabio Staderini, Clemente Capasso, Amedeo Amedei, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1651-1655 (2022)
Several carbonic anhydrase (CA, EC 4.2.1.1) isoforms play an essential role in processes connected to tumorigenesis, as they efficiently accelerate the hydration of carbon dioxide to bicarbonate and proton. In this context, examples are CA IX and CA
Externí odkaz:
https://doaj.org/article/ccdc8927d42a4c0796beaaa633e26856
Autor:
Viviana De Luca, Andrea Angeli, Valeria Mazzone, Claudia Adelfio, Vincenzo Carginale, Andrea Scaloni, Fabrizio Carta, Silvia Selleri, Claudiu T. Supuran, Clemente Capasso
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 62-68 (2022)
Warm-blooded animals may have Malassezia pachydermatis on healthy skin, but changes in the skin microenvironment or host defences induce this opportunistic commensal to become pathogenic. Malassezia infections in humans and animals are commonly treat
Externí odkaz:
https://doaj.org/article/5aced237767d4c40b6a1967628837f35
Autor:
Anna Di Fiore, Viviana De Luca, Emma Langella, Alessio Nocentini, Martina Buonanno, Simona Maria Monti, Claudiu T. Supuran, Clemente Capasso, Giuseppina De Simone
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4185-4194 (2022)
Melioidosis is a severe disease caused by the highly pathogenic gram-negative bacterium Burkholderia pseudomallei. Several studies have highlighted the broad resistance of this pathogen to many antibiotics and pointed out the pivotal importance of im
Externí odkaz:
https://doaj.org/article/e1e1a715c8fe4cd6b9cd71bf1b21ca33