Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Vivian Wy Lui"'
Publikováno v:
The Journal of Pathology. 249:19-25
Multiple primary tumors are defined by the presence of two or more independent primary tumors in the same or different organs of an individual patient. However, the underlying genetic cause for the development of multiple primary tumors is largely un
Autor:
Levi A. Garraway, Eliezer M. Van Allen, Vivian Wy Lui, Fan Zhang, Jennifer R. Grandis, Yan Zeng, Hua Li, Gordon B. Mills, Jonas T. Johnson
Publikováno v:
Cancer Research. 73:4565-4565
Activating mutations of EGFR, primarily found in a subgroup of lung cancers, serve as predictive biomarkers for EGFR tyrosine kinase inhibitor (TKI) sensitivity. Clinical responses to EGFR TKIs in other cancers are only moderate and predictive biomar
Autor:
Cesar Sc Wong, Cecilia Py Lau, Anthony T.C. Chan, Eric K. C. Wong, Edwin P. Hui, Herbert H. Loong, Connie Wc Hui, Vivian Wy Lui
Publikováno v:
Cancer Research. 72:1373-1373
Background: We have previously demonstrated promising activity of sunitinib, a multi-targeted tyrosine kinase inhibitor (TKI) against vascular endothelial growth factor (VEGF) receptor, platelet-derived growth factor receptor (PDGFR), c-kit and RET,
Autor:
S.W. Tsao, Cecilia Lau, Edwin P. Hui, Vivian Wy Lui, Margaret H.L. Ng, Chi Hin Wong, Brigette B.Y. Ma, Connie W.C. Hui, Li Yan, Anthony T.C. Chan
Publikováno v:
Cancer Research. 72:4602-4602
MK2206 is an allosteric inhibitor of AKT with potent activity in cancer cell lines that exhibit genetic aberrations in the PI3K-AKT-PTEN pathway. AKT is frequently activated in nasopharyngeal carcinoma (NPC), while PIK3CA amplification is found in 40
Autor:
Sai Wah Tsao, Cesar Sc Wong, Andrew Sk Chan, Gordon B. Mills, Elaine Yl Wong, Vivian Wy Lui, Anthony T.C. Chan, Cecilia Py Lau, Emily Ky Lam, Edwin P. Hui
Publikováno v:
Cancer Research. 71:1006-1006
TIGAR (TP53-induced glycolysis and apoptosis regulator) is a novel dual regulator of glycolysis and apoptosis regulated by p53. TIGAR was first found to protect normal cells from oxidative stress by inducing cellular production of NADPH, a powerful r
Autor:
Anthony T.C. Chan, Sai Wah Tsao, Brigette B.Y. Ma, Edwin P. Hui, Michael Shi, Kakiu Ho, Vivian Wy Lui, Chi Man Tsang, Cecilia Py Lau, Suk Hang Cheng, Margaret Hl Ng
Publikováno v:
Cancer Research. 70:1638-1638
Undifferentiated nasopharyngeal carcinoma (NPC) is endemic to parts of Asia and ubiquitously associated with Epstein-Barr virus (EBV) infection. AKT is frequently activated in NPC and PIK3CA amplification can be found in 40% of NPC tissues. BEZ235 is
Autor:
Vivian Wy Lui, Raja R. Seethala, Sufi M. Thomas, Stephen Y. Lai, Athanassios Argiris, William E. Gooding, Barton F. Branstetter, Priya Koppikar, Jennifer R. Grandis
Publikováno v:
Journal of Clinical Oncology. 25:6009-6009
6009 Background: SCCHN is characterized by upregulation of the EGFR where EGFR expression levels in the tumor correlate with decreased survival. We developed a novel anti-EGFR therapy with a therapeutic gene consisting of an EGFR AS sequence under th