Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Vivian Tat"'
Autor:
Aleksandra K Drelich, Kempaiah Rayavara, Jason Hsu, Panatda Saenkham-Huntsinger, Barbara M Judy, Vivian Tat, Thomas G Ksiazek, Bi-Hung Peng, Chien-Te K Tseng
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1011777 (2024)
COVID-associated coagulopathy seemly plays a key role in post-acute sequelae of SARS- CoV-2 infection. However, the underlying pathophysiological mechanisms are poorly understood, largely due to the lack of suitable animal models that recapitulate ke
Externí odkaz:
https://doaj.org/article/78ac24cbabc8479ca375a96c56644f89
Autor:
Brandon Carter, Pinghan Huang, Ge Liu, Yuejin Liang, Paulo J. C. Lin, Bi-Hung Peng, Lindsay G. A. McKay, Alexander Dimitrakakis, Jason Hsu, Vivian Tat, Panatda Saenkham-Huntsinger, Jinjin Chen, Clarety Kaseke, Gaurav D. Gaiha, Qiaobing Xu, Anthony Griffiths, Ying K. Tam, Chien-Te K. Tseng, David K. Gifford
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Licensed COVID-19 vaccines ameliorate viral infection by inducing production of neutralizing antibodies that bind the SARS-CoV-2 Spike protein and inhibit viral cellular entry. However, the clinical effectiveness of these vaccines is transitory as vi
Externí odkaz:
https://doaj.org/article/37d4703fe4c94f879a346594ee70e087
Autor:
Jingen Zhu, Swati Jain, Jian Sha, Himanshu Batra, Neeti Ananthaswamy, Paul B. Kilgore, Emily K. Hendrix, Yashoda M. Hosakote, Xiaorong Wu, Juan P. Olano, Adeyemi Kayode, Cristi L. Galindo, Simran Banga, Aleksandra Drelich, Vivian Tat, Chien-Te K. Tseng, Ashok K. Chopra, Venigalla B. Rao
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The U.S. Food and Drug Administration-authorized mRNA- and adenovirus-based SARS-CoV-2 vaccines are intramuscularly injected in two doses and effective in preventing COVID-19, but they do not induce efficient mucosal immunity or prevent vira
Externí odkaz:
https://doaj.org/article/bce3c0d8931d4e4fb22673c9a20b9eda
Autor:
Jiyun Zhu, Linfeng Li, Aleksandra Drelich, Bala C. Chenna, Drake M. Mellott, Zane W. Taylor, Vivian Tat, Christopher Z. Garcia, Ardala Katzfuss, Chien-Te K. Tseng, Thomas D. Meek
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these prote
Externí odkaz:
https://doaj.org/article/83d373bc5b624e3288eb3d76ea8c126b
Autor:
Brandon Carter, Pinghan Huang, Ge Liu, Yuejin Liang, Paulo J.C. Lin, Bi-Hung Peng, Lindsay McKay, Alexander Dimitrakakis, Jason Hsu, Vivian Tat, Panatda Saenkham-Huntsinger, Jinjin Chen, Clarety Kaseke, Gaurav D. Gaiha, Qiaobing Xu, Anthony Griffiths, Ying K. Tam, Chien-Te K. Tseng, David K. Gifford
Clinically licensed COVID-19 vaccines ameliorate viral infection by inducing vaccinee production of neutralizing antibodies that bind to the SARS-CoV-2 Spike protein to inhibit viral cellular entry (Walsh et al., 2020; Baden et al., 2021), however th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9ec084ab6bc6577b4e37eed79a7683
https://doi.org/10.1101/2022.09.23.509206
https://doi.org/10.1101/2022.09.23.509206
Autor:
Aleksandra Drelich, Miriam A. Giardini, Pavla Fajtová, Drake M. Mellott, Vivian Hook, Thomas D. Meek, Jason C. Hsu, Demetrios H. Kostomiris, Aaron F. Carlin, Frank M. Raushel, Klaudia I. Kocurek, Jair L. Siqueira-Neto, Zane W. Taylor, Anthony J. O’Donoghue, Felix W Frueh, Jiyun Zhu, Ardala Katzfuss, Chien Te K. Tseng, Sungjun Beck, Hong Wang, Brett L. Hurst, Laura Beretta, Ken Hirata, James H. McKerrow, Alex E. Clark, Linfeng Li, Daniel C Maneval, Danielle E. Skinner, Balachandra Chenna, Vivian Tat, Michael C Yoon
Publikováno v:
ACS Chemical Biology. 16:642-650
Host-cell cysteine proteases play an essential role in the processing of the viral spike protein of SARS coronaviruses. K777, an irreversible, covalent inactivator of cysteine proteases that has recently completed phase 1 clinical trials, reduced SAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef76261f31ca7bfffc0f062695cd8aeb
https://doi.org/10.1021/acschembio.0c00875
https://doi.org/10.1021/acschembio.0c00875
Autor:
Hang Ma, Chien-Te K. Tseng, Huifang Zong, Yunji Liao, Yong Ke, Haoneng Tang, Lei Wang, Zhenyu Wang, Yang He, Yunsong Chang, Shusheng Wang, Aleksandra Drelich, Jason Hsu, Vivian Tat, Yunsheng Yuan, Mingyuan Wu, Junjun Liu, Yali Yue, Wenbo Xu, Xiaoju Zhang, Ziqi Wang, Li Yang, Hua Chen, Yanlin Bian, Baohong Zhang, Haiyang Yin, Yi Chen, En Zhang, Xiaoxiao Zhang, John Gilly, Tao Sun, Lei Han, Yueqing Xie, Hua Jiang, Jianwei Zhu
Numerous mutations in the spike protein of SARS-CoV-2 B.1.1.529 Omicron variant pose a crisis for antibody-based immunotherapies. The efficacy of emergency use authorized (EUA) antibodies that developed in early SARS-CoV-2 pandemic seems to be in flo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b638adee6d45cf0d13e392b1a319d3a6
https://doi.org/10.1101/2022.02.25.482049
https://doi.org/10.1101/2022.02.25.482049
Autor:
Te Faye Yap, Kempaiah Rayavara, Daniel J. Preston, Jason C. Hsu, K. Tseng Chien-Te, Vivian Tat, Zhen Liu
Publikováno v:
Journal of Hazardous Materials
Dry heat decontamination has been shown to effectively inactivate viruses without compromising the integrity of delicate personal protective equipment (PPE), allowing safe reuse and helping to alleviate shortages of PPE that have arisen due to COVID-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051dc7353e04d95f0643392a8385def0
http://europepmc.org/articles/PMC8572375
http://europepmc.org/articles/PMC8572375
Autor:
Jian Shang, Aleksandra Drelich, Ke Shi, Stanley Perlman, Christopher Massey, Hideki Aihara, Chien Te K. Tseng, Lanying Du, Vivian Tat, Aaron M. LeBeau, Jian Zheng, Joseph P. Gallant, Yushun Wan, Gang Ye, Fang Li, Kempaiah Rayavara Kempaiah, Wanbo Tai, Abby E. Odle, Molly A. Vickers
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
eLife
article-version (status) pre
article-version (number) 1
eLife
Combating the COVID-19 pandemic requires potent and low-cost therapeutics. We identified a novel series of single-domain antibodies (i.e., nanobody), Nanosota-1, from a camelid nanobody phage display library. Structural data showed thatNanosota-1boun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fbd8616f9f67a2414e0fb4437a568a
https://doi.org/10.1101/2020.11.17.386532
https://doi.org/10.1101/2020.11.17.386532
Publikováno v:
The Journal of Immunology. 206:20.15-20.15
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become pandemic, resulting in severe morbidity and mortality around the world. COVID-19 pathogenesis includes lung inflammation, cytokine s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eae5755498daf34526be915665bd6390
https://doi.org/10.4049/jimmunol.206.supp.20.15
https://doi.org/10.4049/jimmunol.206.supp.20.15