Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Vivian R Wang"'
Autor:
Andrew J. Staab, James M. Clark, Steve Weinheimer, Dennis Hernandez, James W. Janc, Joane Litvak, Emma J. Shelton, Jeffrey R. Spencer, Richard Goldsmith, Anthony R. Gangloff, Kenneth D. Rice, David Sperandio, Kap-Sun Yeung, Kyle Elrod, Brian Lee Venables, Nicholas A. Meanwell, Vivian R. Wang, Jason M. Hataye
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3129-3133
Screening of a diverse set of bisbenzimidazoles for inhibition of the hepatitis C virus (HCV) serine protease NS3/NS4A led to the identification of a potent Zn(2+)-dependent inhibitor (1). Optimization of this screening hit afforded a 10-fold more po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2bf90718813bb49178a8c8937321ab
https://doi.org/10.1016/s0960-894x(02)00680-7
https://doi.org/10.1016/s0960-894x(02)00680-7
Autor:
Elaine Y.-L Kuo, Daun Putnam, Kenneth D. Rice, Gangloff Anthony R, Martin Wong, Dener Jeffrey M, William S Newcomb, Vivian R. Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2325-2330
Truncation of potent and selective dibasic inhibitors afforded monocharged inhibitors of human mast-cell tryptase. Using two classes of analogues as lead structures, several monocharged derivatives were identified with K(i) values ranging from 0.084
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f50550b2cc1ee06ce49e786bfc5a875
https://doi.org/10.1016/s0960-894x(01)00444-9
https://doi.org/10.1016/s0960-894x(01)00444-9
Autor:
Gayane Godjoian, Vivian R Wang, Alfredo M Ayala, Carlos G. Gutierrez, Ruben V Martínez, Rolando Martínez-Bernhardt
Publikováno v:
Tetrahedron Letters. 37:433-436
Stannylene acetals prepared from disubstituted vicinal diols can be alkylated with a half equivalent of 1,2-dibromoethane to produce tetrasubstituted triethylene glycols 2 , or with two equivalents of 2-chloroethanol to produce disubstituted triethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5905e8298bc8763c87421ae7045a1127
https://doi.org/10.1016/0040-4039(95)02211-2
https://doi.org/10.1016/0040-4039(95)02211-2
Publikováno v:
Tetrahedron Letters. 43:8459-8461
Conjugated dienes preferentially undergo intramolecular [3+2] cycloaddition to TMM diradicals. Subsequent sigmatropic rearrangement of affords products corresponding to those expected from a direct [4+3] path.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20849998ced5e0190800a81d3cc35494
https://doi.org/10.1016/s0040-4039(02)02098-1
https://doi.org/10.1016/s0040-4039(02)02098-1
Autor:
Emma J. Shelton, Vivian R. Wang, David Sperandio, Gangloff Anthony R, Rice Kenneth D, Joane Litvak
Publikováno v:
Tetrahedron Letters. 42:1441-1443
Tetrabutylammonium fluoride (TBAF) was found to be a mild and efficient catalyst for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles. Using 0.1–1.0 equivalents of TBAF in THF for 1–24 h at room temperature, alkanoyl- and aroyloxyamidines wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aef08fa976e4efca697fd8e2593df51
https://doi.org/10.1016/s0040-4039(00)02288-7
https://doi.org/10.1016/s0040-4039(00)02288-7
Autor:
Vivian R Wang, Gayane Godjoian, Rolando Martínez-Bernhardt, Alfredo M Ayala, Carlos G. Gutierrez, Ruben V Martínez
Publikováno v:
ChemInform. 27
Stannylene acetals prepared from disubstituted vicinal diols can be alkylated with a half equivalent of 1,2-dibromoethane to produce tetrasubstituted triethylene glycols 2 , or with two equivalents of 2-chloroethanol to produce disubstituted triethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44e1c5c5031f66b2627189c51b2e2abf
https://doi.org/10.1002/chin.199619084
https://doi.org/10.1002/chin.199619084
Autor:
Emma J. Shelton, Gangloff Anthony R, David Sperandio, Rice Kenneth D, Vivian R. Wang, Joane Litvak
Publikováno v:
ChemInform. 32
Tetrabutylammonium fluoride (TBAF) was found to be a mild and efficient catalyst for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles. Using 0.1–1.0 equivalents of TBAF in THF for 1–24 h at room temperature, alkanoyl- and aroyloxyamidines wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93448dce363179ae86e05a5459d90086
https://doi.org/10.1002/chin.200121115
https://doi.org/10.1002/chin.200121115
Autor:
Martin Wong, Vivian R. Wang, Elaine Y.-L Kuo, Daun Putnam, Lynne Cregar, Kenneth D. Rice, Wendy B. Young, William S Newcomb, Gangloff Anthony R, Dener Jeffrey M
Publikováno v:
ChemInform. 32
A survey of charged groups and linkers for a series of symmetrical and unsymmetrical dibasic inhibitors is described, leading to several classes of potent and selective inhibitors. In particular, the benzamidine functionality was identified as the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21650afae3afd0676322e5aa638ebe20
https://doi.org/10.1002/chin.200147131
https://doi.org/10.1002/chin.200147131
Autor:
William S Newcomb, Martin Wong, Wendy B. Young, Vivian R. Wang, Daun Putnam, Kenneth D. Rice, Gangloff Anthony R, Dener Jeffrey M, Elaine Y.-L Kuo, Lynne Cregar
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(13)
A survey of charged groups and linkers for a series of symmetrical and unsymmetrical dibasic inhibitors is described, leading to several classes of potent and selective inhibitors. In particular, the benzamidine functionality was identified as the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3caaa9bcf40876bab04f25f2b9020f6b
https://pubmed.ncbi.nlm.nih.gov/11425524
https://pubmed.ncbi.nlm.nih.gov/11425524
Autor:
Elaine Y.-L Kuo, Lynne Cregar, William S Newcomb, Kenneth D. Rice, Lum Robert T, Robert L. Warne, Chris Havel, Daun Putnam, Vivian R. Wang, Martin Wong, Dener Jeffrey M, Anthony R. Gangloff
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(20)
The synthesis and optimization of a novel class of reversible and active-site directed dibasic inhibitors of human mast cell tryptase are described. The compounds were shown to be both remarkably potent and selective for tryptase with Ki values for o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3622f16de6337e0f52a59a105abf45ec
https://pubmed.ncbi.nlm.nih.gov/11055355
https://pubmed.ncbi.nlm.nih.gov/11055355