Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Vivian L Weiss"'
Autor:
Vivian L Weiss, Timothy H Lee, Hong Song, Theodore S Kouo, Chelsea M Black, George Sgouros, Elizabeth M Jaffee, Todd D Armstrong
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31962 (2012)
Cancer vaccines are designed to activate and enhance cancer-antigen-targeted T cells that are suppressed through multiple mechanisms of immune tolerance in cancer-bearing hosts. T regulatory cell (Treg) suppression of tumor-specific T cells is one ba
Externí odkaz:
https://doaj.org/article/8e03c679d1a24ecb8ea89378e05b17c2
Autor:
Victoria H. Ng, Zachary Spencer, Leif R. Neitzel, Anmada Nayak, Matthew A. Loberg, Chen Shen, Sara N. Kassel, Heather K. Kroh, Zhenyi An, Christin C. Anthony, Jamal M. Bryant, Amanda Lawson, Lily Goldsmith, Hassina Benchabane, Amanda G. Hansen, Jingjing Li, Starina D’Souza, Andres M. Lebensohn, Rajat Rohatgi, William A. Weiss, Vivian L. Weiss, Charles Williams, Charles C. Hong, David J. Robbins, Yashi Ahmed, Ethan Lee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The relative abundance of Wnt receptors plays a crucial role in controlling Wnt signaling in tissue homeostasis and human disease. While the ubiquitin ligases that ubiquitylate Wnt receptors are well-characterized, the deubiquitylase that re
Externí odkaz:
https://doaj.org/article/ef64ae66e0614f03b079cfeb3260d710
Autor:
George J. Xu, Matthew A. Loberg, Jean-Nicolas Gallant, Quanhu Sheng, Sheau-Chiann Chen, Brian D. Lehmann, Sophia M. Shaddy, Megan L. Tigue, Courtney J. Phifer, Li Wang, Mario W. Saab-Chalhoub, Lauren M. Dehan, Qiang Wei, Rui Chen, Bingshan Li, Christine Y. Kim, Donna C. Ferguson, James L. Netterville, Sarah L. Rohde, Carmen C. Solórzano, Lindsay A. Bischoff, Naira Baregamian, Aaron C. Shaver, Mitra Mehrad, Kim A. Ely, Daniel W. Byrne, Thomas P. Stricker, Barbara A. Murphy, Jennifer H. Choe, Luciane T. Kagohara, Elizabeth M. Jaffee, Eric C. Huang, Fei Ye, Ethan Lee, Vivian L. Weiss
Publikováno v:
Cell Genomics, Vol 3, Iss 10, Pp 100409- (2023)
Summary: Genomic and transcriptomic analysis has furthered our understanding of many tumors. Yet, thyroid cancer management is largely guided by staging and histology, with few molecular prognostic and treatment biomarkers. Here, we utilize a large c
Externí odkaz:
https://doaj.org/article/fc1b6ef5686b46cf86fe3857f3b602c5
Autor:
Chi Yan, Sheau-Chiann Chen, Gregory D. Ayers, Caroline A. Nebhan, Joseph T. Roland, Vivian L. Weiss, Douglas B. Johnson, Ann Richmond
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-6 (2022)
Abstract Acquired resistance to BRAF/MEK-targeted therapy occurs in the majority of melanoma patients that harbor BRAF mutated tumors, leading to relapse or progression and the underlying mechanism is unclear in many cases. Using multiplex immunohist
Externí odkaz:
https://doaj.org/article/e4ad515d7bef45609e1d3c63d929983a
Autor:
Matthew E. Bechard, Rana Smalling, Akimasa Hayashi, Yi Zhong, Anna E. Word, Sydney L. Campbell, Amanda V. Tran, Vivian L. Weiss, Christine Iacobuzio-Donahue, Kathryn E. Wellen, Oliver G. McDonald
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Distant metastases from pancreatic cancer patients were previously reported by the authors to be dependent on the glucose-metabolizing enzyme phosphogluconate dehydrogenase (PGD). Here the authors report a novel metabolic adaptation that that stably
Externí odkaz:
https://doaj.org/article/4506861df93c451294cd63802d5a994b
Autor:
Kensey N. Bergdorf, Courtney J. Phifer, Matthew E. Bechard, Mason A. Lee, Oliver G. McDonald, Ethan Lee, Vivian L. Weiss
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100578- (2021)
Summary: Our organoid generation technique has allowed for the development of downstream organoid applications. Here, we detail an accessible, straightforward protocol for immunofluorescent staining and imaging of thyroid cancer organoids, particular
Externí odkaz:
https://doaj.org/article/dfec79b1216148019e6d990d20a2546f
Autor:
Courtney J. Phifer, Kensey N. Bergdorf, Matthew E. Bechard, Anna Vilgelm, Naira Baregamian, Oliver G. McDonald, Ethan Lee, Vivian L. Weiss
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100220- (2021)
Summary: Patient-derived tumor organoid cultures are an essential and innovative methodology for translational research. However, current techniques to establish these cultures are cumbersome, expensive, and often require irreplaceable clinical tissu
Externí odkaz:
https://doaj.org/article/2191ce4fe9eb4249bf0083cec3ced77e
Autor:
Naira Baregamian, Konjeti R. Sekhar, Evan S. Krystofiak, Maria Vinogradova, Giju Thomas, Emmanuel Mannoh, Carmen C. Solórzano, Colleen M. Kiernan, Anita Mahadevan-Jansen, Naji Abumrad, Michael L. Freeman, Vivian L. Weiss, Jeffrey C. Rathmell, W. Kimryn Rathmell
Publikováno v:
Surgery. 173:67-75
Recent advancements in 3-dimensional patient-derived organoid models have revolutionized the field of cancer biology. There is an urgent need for development of endocrine tumor organoid models for medullary thyroid carcinoma, adrenocortical carcinoma
Autor:
Ruey Hu, MD, MPH, George Xu, Thomas Stricker, MD, PhD, Bingshan Li, PhD, Vivian L. Weiss, MD, PhD, Lindsay Bischoff, MD
Publikováno v:
AACE Clinical Case Reports, Vol 6, Iss 5, Pp e273-e278 (2020)
ABSTRACT: Objective: Here we present 2 cases of papillary thyroid microcarcinomas (PMCs) that had metastasized at presentation. The 2015 American Thyroid Association and the American College of Radiology Thyroid Imaging Reporting and Data System (TI-
Externí odkaz:
https://doaj.org/article/2991f365b0cd4528bc2348ca03950046
Autor:
Anna E. Vilgelm, Kensey Bergdorf, Melissa Wolf, Vijaya Bharti, Rebecca Shattuck-Brandt, Ashlyn Blevins, Caroline Jones, Courtney Phifer, Mason Lee, Cindy Lowe, Rachel Hongo, Kelli Boyd, James Netterville, Sarah Rohde, Kamran Idrees, Joshua A. Bauer, David Westover, Bradley Reinfeld, Naira Baregamian, Ann Richmond, W. Kimryn Rathmell, Ethan Lee, Oliver G. McDonald, Vivian L. Weiss
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101408- (2020)
Summary: Patient-derived cancer organoids hold great potential to accurately model and predict therapeutic responses. Efficient organoid isolation methods that minimize post-collection manipulation of tissues would improve adaptability, accuracy, and
Externí odkaz:
https://doaj.org/article/8afed6fb0a4e4ebb9491411bebb640fc