Engineering transferrable microvascular meshes for subcutaneous islet transplantation

Autor: Wei Song, Alan Chiu, Long-Hai Wang, Robert E. Schwartz, Bin Li, Nikolaos Bouklas, Daniel T. Bowers, Duo An, Soon Hon Cheong, James A. Flanders, Yehudah Pardo, Qingsheng Liu, Xi Wang, Vivian K. Lee, Guohao Dai, Minglin Ma

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

The success of engineered tissue depends on the integration of a dense vascular network to supply nutrients and remove waste products. Here the authors design high density microvascular meshes made through an anchored self-assembly mechanism, and use

Externí odkaz: https://doaj.org/article/5c336738950d43f49fb0ec15b15f0af4

Three Dimensional Bioprinting of a Vascularized and Perfusable Skin Graft Using Human Keratinocytes, Fibroblasts, Pericytes, and Endothelial Cells

Autor: Jordan S. Pober, Guohao Dai, Tânia Baltazar, Carolina Motter Catarino, Catherine B. Xie, Vivian K. Lee, Stéphanie Yuki Kolbeck Hotta, Frederico Castelo Ferreira, Pankaj Karande, Jonathan Merola, W. Mark Saltzman, Nancy C. Kirkiles-Smith, Xiaowei Xu

Publikováno v: Baltazar, T, Merola, J, Catarino, C, Xie, C B, Kirkiles-Smith, N C, Lee, V, Hotta, S, Dai, G, Xu, X, Ferreira, F C, Saltzman, W M, Pober, J S & Karande, P 2020, ' Three Dimensional Bioprinting of a Vascularized and Perfusable Skin Graft Using Human Keratinocytes, Fibroblasts, Pericytes, and Endothelial Cells ', Tissue Engineering. Part A, vol. 26, no. 5-6, pp. 227-238 . https://doi.org/10.1089/ten.TEA.2019.0201
Tissue Eng Part A

Multilayered skin substitutes comprising allogeneic cells have been tested for the treatment of nonhealing cutaneous ulcers. However, such nonnative skin grafts fail to permanently engraft because they lack dermal vascular networks important for inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafb54f6cb8fb26975c37d9eb5a89c5c
https://doi.org/10.1089/ten.tea.2019.0201

ANGI-13. PLEXIN-B2 FACILITATES DIFFUSE GLIOMA INVASION BY REGULATING CELL ADHESION AND ACTO-MYOSIN DYNAMICS

Autor: Yong Huang, Vivian K. Lee, Ramsey A. Foty, Chrystian Junqueira Alves, Guohao Dai, Roland H. Friedel, Rut Tejero, Hongyan Zou

Publikováno v: Neuro Oncol

Diffuse invasion of glioblastoma (GBM) cells into brain tissue is a key factor for its high lethality. GBM cell migration is affected by functions of plexins, which are transmembrane receptors of semaphorins that regulate cell adhesion and cytoskelet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d149b93670e25a10d3b1e0f8d0118fa
https://europepmc.org/articles/PMC6847662/

High Resolution Tomographic Analysis of in vitro 3D Glioblastoma Tumor Model under Long-Term Drug Treatment

Autor: Mehmet S. Ozturk, Vivian K. Lee, Guohao Dai, Hongyan Zou, Roland H. Friedel, Xavier Intes

Glioblastoma multiforme (GBM) is an extremely lethal type of brain tumor as it frequently develops therapeutic resistance over months of chemotherapy cycles. Hence, there is a critical need to provide relevant biological systems to guide the developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a1b58d6355978d972b04630f5073de

Engineering transferrable microvascular meshes for subcutaneous islet transplantation

Autor: Robert E. Schwartz, Vivian K. Lee, James A. Flanders, Bin Li, Alan Chiu, Minglin Ma, Daniel T. Bowers, Guohao Dai, Xi Wang, Duo An, Yehudah Pardo, Long-Hai Wang, Nikolaos Bouklas, Wei Song, Qingsheng Liu, Soon Hon Cheong

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

The success of engineered cell or tissue implants is dependent on vascular regeneration to meet adequate metabolic requirements. However, development of a broadly applicable strategy for stable and functional vascularization has remained challenging.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663a6724b7b2f501b64b50b1560c7e22
https://pubmed.ncbi.nlm.nih.gov/31601796