Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Vivian Gonzalez-Perez"'
Autor:
Pedro L Martinez-Espinosa, Jianping Wu, Chengtao Yang, Vivian Gonzalez-Perez, Huifang Zhou, Hongwu Liang, Xiao-Ming Xia, Christopher J Lingle
Publikováno v:
eLife, Vol 4 (2015)
Two mammalian genes, Kcnt1 and Kcnt2, encode pore-forming subunits of Na+-dependent K+ (KNa) channels. Progress in understanding KNa channels has been hampered by the absence of specific tools and methods for rigorous KNa identification in native cel
Externí odkaz:
https://doaj.org/article/3e7131681543466e9bccd504328f46df
Publikováno v:
J Physiol
Large conductance K(+) channels, termed BK channels, regulate a variety of cellular and physiologic functions. Although universally activated by changes in voltage or [Ca(2+)](i), the threshold for BK channel activation varies among loci of expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2bf06b1dc2a8029fc77ff65e66e30cf
https://doi.org/10.1113/jp281952
https://doi.org/10.1113/jp281952
Autor:
Xiao Ming Xia, Monica Sala-Rabanal, Pedro L. Martinez-Espinosa, Nikhil Bharadwaj, Jenny K. Gustafsson, Vivian Gonzalez-Perez, Albert C. Chen, Hongzhen Hu, Christopher J. Lingle, Matthew A. Ciorba, David M. Alvarado
Publikováno v:
Proc Natl Acad Sci U S A
Goblet cells (GCs) are specialized cells of the intestinal epithelium contributing critically to mucosal homeostasis. One of the functions of GCs is to produce and secrete MUC2, the mucin that forms the scaffold of the intestinal mucus layer coating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b162ec5885208bbd51ec8b4eaeb23bb
https://doi.org/10.1101/2020.10.23.341396
https://doi.org/10.1101/2020.10.23.341396
Publikováno v:
Proceedings of the National Academy of Sciences. 115:9923-9928
Structural symmetry is a hallmark of homomeric ion channels. Nonobligatory regulatory proteins can also critically define the precise functional role of such channels. For instance, the pore-forming subunit of the large conductance voltage and calciu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6635ff527f8a74ecb31516bb4504d4fd
https://doi.org/10.1073/pnas.1804560115
https://doi.org/10.1073/pnas.1804560115
Autor:
Hans Moldenhauer, David Naranjo, Vivian Gonzalez-Perez, Nieves Navarro-Quezada, Ignacio Diaz-Franulic
Publikováno v:
Proceedings of the National Academy of Sciences. 115:8203-8208
Indexación: Scopus. ACKNOWLEDGMENTS. We thank Chris Lingle and Yu Zhou (Washington University) for critical reading of the manuscript and Victoria Prado for Xenopus care and oocyte preparation. We also thank Millennium Scientific Initiative P029-022
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27aff654cbcb9bcbb006a49629af9a8
https://doi.org/10.1073/pnas.1806578115
https://doi.org/10.1073/pnas.1806578115
Ca2+- and voltage-gated K+ channels of large conductance (BK channels) are expressed in a diverse variety of both excitable and inexcitable cells, with functional properties presumably uniquely calibrated for the cells in which they are found. Althou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de82966182df14d453f94fcdff910804
https://europepmc.org/articles/PMC6380188/
https://europepmc.org/articles/PMC6380188/
Autor:
Xiao-Ming Xia, James E. Melvin, Taro Mukaibo, Vivian Gonzalez-Perez, Christopher J. Lingle, Chengtao Yang
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Leucine-rich-repeat-containing protein 26 (LRRC26) is the regulatory γ1 subunit of Ca2+- and voltage-dependent BK-type K+ channels. BK channels that contain LRRC26 subunits are active near normal resting potentials even without Ca2+, suggesting they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac5311ff65dacd5a61a33d6f0682f3b
https://doi.org/10.1073/pnas.1703081114
https://doi.org/10.1073/pnas.1703081114
Autor:
Vivian Gonzalez-Perez, Xiao-Ming Xia, Chengtao Yang, Christopher J. Lingle, Pedro L. Martinez-Espinosa
Publikováno v:
The Journal of General Physiology
Chromaffin cells from mice lacking the BK β2 subunit show decreased action potential firing during current injection but an increase in spontaneous burst firing.
Rat and mouse adrenal medullary chromaffin cells (CCs) express an inactivating BK
Rat and mouse adrenal medullary chromaffin cells (CCs) express an inactivating BK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276c98ef62a7bac95d9091c9af9491ae
https://doi.org/10.1085/jgp.201411253
https://doi.org/10.1085/jgp.201411253
Autor:
Xiao-Ming Xia, Pedro L. Martinez-Espinosa, Nikhil Bharadwaj, Monica Sala-Rabanal, Vivian Gonzalez-Perez, Matthew A. Ciorba, Christopher J. Lingle
Publikováno v:
Gastroenterology. 156:S85
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8daee2630d0343dfda9e08906fb19b
https://doi.org/10.1053/j.gastro.2019.01.197
https://doi.org/10.1053/j.gastro.2019.01.197
Publikováno v:
Nature
Two-step BK channel inactivation mediated by an intrinsically disordered BK β-subunit peptide involves a stereospecific binding interaction that precedes blockade. After K+ ion channels open, they frequently 'inactivate' when a cytosolic segment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313e3a9b25a42eae8beb8b4a11180a7c
http://europepmc.org/articles/PMC3348258
http://europepmc.org/articles/PMC3348258