Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Vivian Chua"'
Autor:
Vivian Chua, Marlana Orloff, Jessica LF Teh, Takahito Sugase, Connie Liao, Timothy J Purwin, Bao Q Lam, Mizue Terai, Grazia Ambrosini, Richard D Carvajal, Gary Schwartz, Takami Sato, Andrew E Aplin
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 2, Pp 1-16 (2019)
Abstract Alterations in transcriptional programs promote tumor development and progression and are targetable by bromodomain and extraterminal (BET) protein inhibitors. However, in a multi‐site clinical trial testing the novel BET inhibitor, PLX511
Externí odkaz:
https://doaj.org/article/ad9494b5987a443bb7fdef74004cf81b
Autor:
VIVIAN CHUA, LI JING CHONG, YAN TAN, XIN YING TENG, PUI EE NG, FATHMATH EMAN MOHAMED, CAI PING KOH, NAM WENG SIT
Publikováno v:
Acta Poloniae Pharmaceutica; May/Jun2024, Vol. 81 Issue 3, p467-481, 15p
Autor:
Aplin, Anna Han, Dzmitry Mukha, Vivian Chua, Timothy J. Purwin, Manoela Tiago, Bhavik Modasia, Usman Baqai, Jenna L. Aumiller, Nelisa Bechtel, Emily Hunter, Meggie Danielson, Mizue Terai, Philip B. Wedegaertner, Takami Sato, Solange Landreville, Michael A. Davies, Stefan Kurtenbach, J. William Harbour, Zachary T. Schug, Andrew E.
Publikováno v:
Cancers; Volume 15; Issue 13; Pages: 3451
Uveal melanoma (UM) displays a high frequency of metastasis; however, effective therapies for metastatic UM are limited. Identifying unique metabolic features of UM may provide a potential targeting strategy. A lipid metabolism protein expression sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::b28f5cc1baa42f552d8710310248e0a9
Supplementary Figures 1-5 from Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma
Autor:
Andrew E. Aplin, Julio Aguirre-Ghiso, Michael A. Davies, Takami Sato, Nelisa Bechtel, Connie Liao, Usman Baqai, Prem Patel, Vivian Chua, Anna Han, Timothy J. Purwin, Jessica L.F. Teh
Supplemental Figure 1. CDK4/6i + MEKi treatment does not modulate proteins within the apoptotic signaling pathway. Supplemental Figure 2. Growth of UM001 xenografts treated with MEKi and/or CDK4/6i. Supplemental Figure 3. RNA-seq samples cluster base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85006f5b1b7ea2fe04bccacbd4f5ada8
https://doi.org/10.1158/1535-7163.22521028
https://doi.org/10.1158/1535-7163.22521028
Autor:
Andrew E. Aplin, J. William Harbour, Jeffim N. Kuznetsoff, Edward J. Hartsough, Anna Han, Vivian Chua, Nelisa Bechtel, Timothy J. Purwin, Usman Baqai
Supplementary Data from Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20af899ad689f236b717ccd27af4793c
https://doi.org/10.1158/1541-7786.22527609
https://doi.org/10.1158/1541-7786.22527609
Autor:
Andrew E. Aplin, Takami Sato, Michael A. Davies, Ken Kageyama, Mizue Terai, Timothy J. Purwin, Connie Liao, Vivian Chua, Hanyin Cheng
Supplemental Table 1: Patient characteristics and treatment history.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c8eff6353e333392a201e27a98f86c
https://doi.org/10.1158/1535-7163.22509588
https://doi.org/10.1158/1535-7163.22509588
Autor:
Andrew E. Aplin, Julio Aguirre-Ghiso, Michael A. Davies, Takami Sato, Nelisa Bechtel, Connie Liao, Usman Baqai, Prem Patel, Vivian Chua, Anna Han, Timothy J. Purwin, Jessica L.F. Teh
Supplemental Table 1. RNA Seq z-score values for genes significantly up- or downregulated in MEKi-R or CDK4/6i-T groups compared to controls, corresponding to figure 3A. Data are indexed to show which genes are significant for each comparison (BHFDR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010561c8e09e98e68d8256516c17c305
https://doi.org/10.1158/1535-7163.22521025.v1
https://doi.org/10.1158/1535-7163.22521025.v1
Autor:
Andrew E. Aplin, Takami Sato, Michael A. Davies, Ken Kageyama, Mizue Terai, Timothy J. Purwin, Connie Liao, Vivian Chua, Hanyin Cheng
Patients with metastatic uveal melanoma usually die within 1 year of diagnosis, emphasizing an urgent need to develop new treatment strategies. The liver is the most common site of metastasis. Mitogen-activated protein kinase kinase (MEK) inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a73bcb3b678a5be53735d3d8802761
https://doi.org/10.1158/1535-7163.c.6539340
https://doi.org/10.1158/1535-7163.c.6539340
Autor:
Andrew E. Aplin, Julio Aguirre-Ghiso, Michael A. Davies, Takami Sato, Nelisa Bechtel, Connie Liao, Usman Baqai, Prem Patel, Vivian Chua, Anna Han, Timothy J. Purwin, Jessica L.F. Teh
Frequent GNAQ and GNA11 mutations in uveal melanoma hyperactivate the MEK–ERK signaling pathway, leading to aberrant regulation of cyclin-dependent kinases (CDK) and cell-cycle progression. MEK inhibitors (MEKi) alone show poor efficacy in uveal me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8060e37103f45fc1d0c5ac98b19764a9
https://doi.org/10.1158/1535-7163.c.6542872
https://doi.org/10.1158/1535-7163.c.6542872
Autor:
Andrew E. Aplin, J. William Harbour, Jeffim N. Kuznetsoff, Edward J. Hartsough, Anna Han, Vivian Chua, Nelisa Bechtel, Timothy J. Purwin, Usman Baqai
Supplementary Figure from Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5baa07879eb936f8d44c7e0ed2a573
https://doi.org/10.1158/1541-7786.22527606
https://doi.org/10.1158/1541-7786.22527606