Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Vivian, Hook"'
Autor:
Jehad Almaliti, Momen Alhindy, Michael C. Yoon, Vivian Hook, Tadeusz F. Molinski, Anthony J. O’Donoghue, William H. Gerwick
Publikováno v:
ACS Omega, Vol 9, Iss 3, Pp 3997-4003 (2024)
Externí odkaz:
https://doaj.org/article/c37339e22da74790a82befae2753392d
Autor:
Ben Boyarko, Sonia Podvin, Barry Greenberg, Jeremiah D. Momper, Yadong Huang, William H. Gerwick, Anne G. Bang, Luisa Quinti, Ana Griciuc, Doo Yeon Kim, Rudolph E. Tanzi, Howard H. Feldman, Vivian Hook
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Therapeutics discovery and development for Alzheimer’s disease (AD) has been an area of intense research to alleviate memory loss and the underlying pathogenic processes. Recent drug discovery approaches have utilized in silico computational strate
Externí odkaz:
https://doaj.org/article/d3f3f5cf111246e3bec8557366792dd9
Autor:
Shanshan Wang, Joseph S. Leem, Sonia Podvin, Vivian Hook, Natalia Kleschevnikov, Paul Savchenko, Mehul Dhanani, Kimberly Zhou, Isabella C. Kelly, Tong Zhang, Atsushi Miyanohara, Phuong Nguyen, Alexander Kleschevnikov, Steve L. Wagner, John Q. Trojanowski, David M. Roth, Hemal H. Patel, Piyush M. Patel, Brian P. Head
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 434-450 (2021)
Alzheimer’s disease (AD) is the most common form of neurodegeneration and cognitive dysfunction in the elderly. Identifying molecular signals that mitigate and reverse neurodegeneration in AD may be exploited therapeutically. Transgenic AD mice (PS
Externí odkaz:
https://doaj.org/article/9a008a9a994349fab892e7d7e193a9c9
Autor:
Sonia Podvin, Alexander Jones, Qing Liu, Brent Aulston, Charles Mosier, Janneca Ames, Charisse Winston, Christopher B. Lietz, Zhenze Jiang, Anthony J. O’Donoghue, Tsuneya Ikezu, Robert A. Rissman, Shauna H. Yuan, Vivian Hook
Publikováno v:
ACS Omega, Vol 6, Iss 20, Pp 13033-13056 (2021)
Externí odkaz:
https://doaj.org/article/85df60e77971439a9aa48ddc16680670
Autor:
Ben Boyarko, Vivian Hook
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The human tau protein is implicated in a wide range of neurodegenerative “tauopathy” diseases, consisting of Alzheimer’s disease (AD) and frontotemporal lobar degeneration which includes progressive supranuclear palsy, corticobasal degeneration
Externí odkaz:
https://doaj.org/article/cb4ba1ac247c41ee9191c586140b259e
Autor:
Sonia Podvin, Zhenze Jiang, Ben Boyarko, Leigh-Ana Rossitto, Anthony O’Donoghue, Robert A. Rissman, Vivian Hook
Publikováno v:
ACS Chemical Neuroscience. 13:1992-2005
Synaptic dysfunction and loss occur in Alzheimer's disease (AD) brains, which results in cognitive deficits and brain neurodegeneration. Neuropeptides comprise the major group of synaptic neurotransmitters in the nervous system. This study evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55a291fb7a244e3179cab74ef3e8736
https://doi.org/10.1021/acschemneuro.2c00222
https://doi.org/10.1021/acschemneuro.2c00222
Publikováno v:
J Alzheimers Dis
The lysosomal cysteine protease cathepsin B (CTSB) has been suggested as a biomarker for Alzheimer’s disease (AD) because elevated serum CTSB in AD patients has been found to correlate with cognitive dysfunction. Furthermore, CTSB gene knockout (KO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615650dd4bf051a5365488e69fc3a8d6
https://europepmc.org/articles/PMC10185432/
https://europepmc.org/articles/PMC10185432/
Autor:
Elisa Maffioli, Zhenze Jiang, Simona Nonnis, Armando Negri, Valentina Romeo, Christopher B. Lietz, Vivian Hook, Giuseppe Ristagno, Giuseppe Baselli, Erik B. Kistler, Federico Aletti, Anthony J. O’Donoghue, Gabriella Tedeschi
Publikováno v:
Molecules, Vol 25, Iss 18, p 4071 (2020)
Proteomic technologies have identified 234 peptidases in plasma but little quantitative information about the proteolytic activity has been uncovered. In this study, the substrate profile of plasma proteases was evaluated using two nano-LC-ESI-MS/MS
Externí odkaz:
https://doaj.org/article/56f4355b40ca4683aca2643805949002
Publikováno v:
Heliyon, Vol 4, Iss 7, Pp e00673- (2018)
Proteases are required to generate active peptide neurotransmitters, known as neuropeptides, from pro-neuropeptides. Model animal systems have recently illustrated roles for the cathepsin V (CTSV) and cathepsin L (CTSL) cysteine proteases, combined w
Externí odkaz:
https://doaj.org/article/59a98c129f914ba991cac300c47c4e0c
Autor:
Leigh-Ana Rossitto, Robert H. Mills, Rebecca Daly, Vivian Hook, Dilip V. Jeste, Toer W. Stevens, Anaamika Campeau, David Gonzalez, Pieter C. Dorrestein, Michael J. Meehan, Tanya T. Nguyen
Publikováno v:
Molecular Psychiatry. 27:1217-1225
Schizophrenia is a devastating psychiatric illness that detrimentally affects a significant portion of the worldwide population. Aging of schizophrenia patients is associated with reduced longevity, but the potential biological factors associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09ae6d11b960fd6ec3caa26f95a3023f
https://doi.org/10.1038/s41380-021-01339-z
https://doi.org/10.1038/s41380-021-01339-z