Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Vivi F. H. Jensen"'
Autor:
Vivi F. H. Jensen, Anne-Marie Mølck, Jette Nowak, Johannes J. Fels, Jens Lykkesfeldt, Ingrid B. Bøgh
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Pancreatic β-cells have an extraordinary ability to adapt to acute fluctuations in glucose levels by rapid changing insulin production to meet metabolic needs. Although acute changes have been characterised, effects of prolonged metabolic s
Externí odkaz:
https://doaj.org/article/e3de2ad81ff644939436faa21a79b44b
Autor:
Vivi F. H. Jensen, Anne-Marie Mølck, Melissa Chapman, Lene Alifrangis, Lene Andersen, Jens Lykkesfeldt, Ingrid B. Bøgh
Publikováno v:
International Journal of Endocrinology, Vol 2017 (2017)
The brain is vulnerable to hypoglycaemia due to a continuous need of energy substrates to meet its high metabolic demands. Studies have shown that severe acute insulin-induced hypoglycaemia results in oxidative stress in the rat brain, when neuroglyc
Externí odkaz:
https://doaj.org/article/e70575f29fa044dc8a5932cf5841bac9
Autor:
Vivi F. H. Jensen, Line H. Schefe, Helene Jacobsen, Anne-Marie Mølck, Kasper Almholt, Ingrid Sjögren, Charlotte M. Dalsgaard, Rikke K Kirk, Andrew J. Benie, Bent O. Petersen, Mette S. Kyhn, Anne J. Overgaard, Inga Bjørnsdottir, Diane R. Stannard, Hanne K. Offenberg, Emil Egecioglu
Publikováno v:
International journal of toxicology. 41(6)
N9-GP/Rebinyn®/Refixia® is an approved PEGylated (polyethylene glycol-conjugated) recombinant human factor IX intended for prophylactic and/or on-demand treatment in adults and children with haemophilia B. A juvenile neurotoxicity study was conduct
Autor:
Anne-Marie Mølck, Ingrid Sjögren, Jette Nowak, Vivi F. H. Jensen, Inger Thorup, Peter R. Brinck
Publikováno v:
International Journal of Toxicology. 39:560-576
For nonclinical safety-assessment of insulin analogues in vivo, mitogenic effects are compared to that of human insulin. Besides histopathologic evaluation, this usually includes assessment of cell proliferation (CP) in mammary glands. Insulin analog
Autor:
Vivi F. H. Jensen, Anne-Marie Mølck, Jette Nowak, Maria Wohlfarth, Eva Nüsken, Damien Demozay, Kai-Dietrich Nüsken, Ingrid B. Bøgh
Publikováno v:
PLOS ONE. 17:e0265988
Maternal malnutrition is associated with decreased nutrient transfer to the foetus, which may lead to foetal growth restriction, predisposing children to a variety of diseases. However, regulation of placental nutrient transfer during decreased nutri
Autor:
Louise Pedersen, Jette Nowak, Pernille Tveden-Nyborg, Anne Marie Mølck, Birgitte M. Viuff, Jens Lykkesfeldt, Vivi F. H. Jensen, Suzi H. Madsen, Kristina Åkesson, Johannes Josef Fels, Ingrid Brück Bøgh, Fiona E. McGuigan, Charlotte Lund Rasmussen
Publikováno v:
Scientific Reports
Jensen, V F H, Mølck, A-M, Bøgh, I B, Nowak, J, Viuff, B M, Rasmussen, C L M, Pedersen, L, Fels, J J, Madsen, S H, McGuigan, F E, Tveden-Nyborg, P, Lykkesfeldt, J & Akesson, K E 2020, ' Inner histopathologic changes and disproportionate zone volumes in foetal growth plates following gestational hypoglycaemia in rats ', Scientific Reports, vol. 10, no. 1, 5609 . https://doi.org/10.1038/s41598-020-62554-2
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Jensen, V F H, Mølck, A-M, Bøgh, I B, Nowak, J, Viuff, B M, Rasmussen, C L M, Pedersen, L, Fels, J J, Madsen, S H, McGuigan, F E, Tveden-Nyborg, P, Lykkesfeldt, J & Akesson, K E 2020, ' Inner histopathologic changes and disproportionate zone volumes in foetal growth plates following gestational hypoglycaemia in rats ', Scientific Reports, vol. 10, no. 1, 5609 . https://doi.org/10.1038/s41598-020-62554-2
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Maternal hypoglycaemia throughout gestation until gestation day (GD)20 delays foetal growth and skeletal development. While partially prevented by return to normoglycaemia after completed organogenesis (GD17), underlying mechanisms are not fully unde
Publikováno v:
Reproductive Toxicology. 77:1-24
Glucose is the major energy substrate during embryogenesis and the embryo is dependent on glucose from the maternal circulation to ensure normal metabolism and growth. The placenta plays a key role in this nutrient transfer in mammals, both during em
Autor:
Anne-Marie Mølck, Vivi F. H. Jensen, Jette Nowak, Ingrid Brück Bøgh, Henrik Søeborg, Melissa Chapman, Jens Lykkesfeldt
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 122:165-175
Peripheral neuropathy is one of the most common complications of diabetic hyperglycaemia. Insulin-induced hypoglycaemia (IIH) might potentially exacerbate or contribute to neuropathy as hypoglycaemia also causes peripheral neuropathy. In rats, IIH in
Autor:
Vivi F. H. Jensen, Ruth Renaut, Lene Nonboe Andersen, Kristina Åkesson, Johannes Josef Fels, Anne Marie Mølck, Ingrid Brück Bøgh, Fiona E. McGuigan, Jens Lykkesfeldt
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 91
The aim was to investigate embryo-foetal effects of continuous maternal insulin-induced hypoglycaemia extending throughout gestation or until gestation day (GD)17 (typical last day of dosing during pre-clinical evaluation) providing comparator data f
Autor:
Anne-Marie Mølck, Ingrid Brück Bøgh, Jens Lykkesfeldt, Melissa Chapman, Lene Nonboe Andersen, Lene Alifrangis, Vivi F. H. Jensen
Publikováno v:
Jensen, V F H, Molck, A-M, Chapman, M, Alifrangis, L, Andersen, L, Lykkesfeldt, J & Bogh, I B 2017, ' Chronic Hyperinsulinaemic Hypoglycaemia in Rats Is Accompanied by Increased Body Weight, Hyperleptinaemia, and Decreased Neuronal Glucose Transporter Levels in the Brain ', International Journal of Endocrinology, vol. 2017, 7861236 . https://doi.org/10.1155/2017/7861236
International Journal of Endocrinology, Vol 2017 (2017)
International Journal of Endocrinology
International Journal of Endocrinology, Vol 2017 (2017)
International Journal of Endocrinology
The brain is vulnerable to hypoglycaemia due to a continuous need of energy substrates to meet its high metabolic demands. Studies have shown that severe acute insulin-induced hypoglycaemia results in oxidative stress in the rat brain, when neuroglyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f282d1ecd9513ea67c29b835efac0a
https://curis.ku.dk/portal/da/publications/chronic-hyperinsulinaemic-hypoglycaemia-in-rats-is-accompanied-by-increased-body-weight-hyperleptinaemia-and-decreased-neuronal-glucose-transporter-levels-in-the-brain(a74a1a3a-7233-4ea1-b614-eb0b3e8ea6e9).html
https://curis.ku.dk/portal/da/publications/chronic-hyperinsulinaemic-hypoglycaemia-in-rats-is-accompanied-by-increased-body-weight-hyperleptinaemia-and-decreased-neuronal-glucose-transporter-levels-in-the-brain(a74a1a3a-7233-4ea1-b614-eb0b3e8ea6e9).html