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Autor:
Jean L, Grem, Nancy, Harold, Bruce, Keith, Alice P, Chen, Viven, Kao, Chris H, Takimoto, J Michael, Hamilton, Janet, Pang, Marie, Pace, Gada B, Jasser, Mary G, Quinn, Brian P, Monahan
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 8(7)
Pyrazoloacridine (PZA) is an investigational nucleic acid binding agent that inhibits the activity of topoisomerases I and II through a mechanism distinct from other topoisomerase poisons. PZA shows schedule-independent cytotoxicity against tumor cel