Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Vivekanand P. Kamath"'
Autor:
Vivekanand P. Kamath, Jesus J. Juarez-Brambila, Christopher B. Morris, Christopher D. Winslow, Philip E. Morris
Publikováno v:
Organic Process Research & Development. 13:928-932
A practical synthesis of the purine nucleoside phosphorylase (PNP) inhibitor BCX-4208 (1) was accomplished in three telescoped steps. Mannich condensation of the 4-benzyloxy-9-deazahypoxanthine with (3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine and
Autor:
Jonathan M. Gregson, Vivekanand P. Kamath, Robert E. Yeske, Ying R. Fang, R. Murray Ratcliffe, Monica M. Palcic
Publikováno v:
Carbohydrate Research. 339:1141-1146
The Pk-trisaccharide, linked to a solid carrier, is a potential agent for neutralization of shiga-like toxin in the gastrointestinal tract. Two approaches to the multigram-scale synthesis of a linkable Pk-trisaccharide derivative were therefore inves
Autor:
R. Murray Ratcliffe, Ying R. Fang, Jonathan M. Gregson, Monica M. Palcic, Vivekanand P. Kamath, Robert E. Yeske
Publikováno v:
Synthesis. 2004:2293-2296
Trisaccharide 1, 8-methoxycarbonyloctyl-O-(α-D-galactopyranosyl)-(1→3)-(β-D-galactopyranosyl)-(1→4)-β-D-glucopyranoside, linked to a solid support can be used to remove Clostridium difficile toxin A from the intestinal tract. Therefore, multi-
Autor:
Vivekanand P. Kamath, Markus B. Streiff, Albin Otter, Yeuk-Chuen Liu, Monica M. Palcic, Hong Li
Publikováno v:
Canadian Journal of Chemistry. 80:540-545
The enzymatic synthesis of trimeric sialyl Lewisxpentadecasaccharide (6), a 15-mer, from a trimannoside precursor required six different glycosyltransferase enzymes and four nucleotide donor sugars. Three N-acetylglucosaminyl residues were transferre
Publikováno v:
Tetrahedron Letters. 50:5198-5200
Forodesine HCl is being investigated as a potential target for the control of T-cell proliferation. Herein we present an alternative route for the synthesis of the target molecule with addition of lactam to the lithiated deazahypoxanthine (generated
Autor:
Vivekanand P, Kamath, Jie, Xue, Jesus J, Juarez-Brambila, Christopher B, Morris, Rakesh, Ganorkar, Philip E, Morris
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2624-2626
Forodesine HCl is being investigated as a potential therapeutic target for the control of T-cell proliferation. During our ongoing process development work on forodesine HCl several novel compounds were identified as possible impurities in the proces
Publikováno v:
Drug Testing and Analysis. 1:125-127
BCX-4208, a novel inhibitor of the enzyme purine nucleoside phosphorylase, mimics the charged ribosyl oxocarbenium ion formed during the transition state of the enzyme-catalyzed C-N bond cleavage of nucleosides. A slow-onset, tight-binding inhibitor
Publikováno v:
Glycoconjugate Journal. 16:599-606
We report the chemical synthesis of αFuc(1→2)αGal-O(CH2)7CH3 (1) an analog of the natural blood group (O)H disaccharide αFuc(1→2)βGal-OR. Compound 1 was a good substrate for recombinant blood group B glycosyltransferase (GTB) and was used as
Publikováno v:
Glycoconjugate Journal. 13:315-319
The 8-methoxycarbonyloctyl glycosides of GlcNAc beta, Gal beta 1-4Glc beta, Fuc alpha 1-2Fuc alpha 1-3GalNAc beta and Fuc alpha 1-2Gal beta 1-3[Fuc alpha 1-4]GlcNac beta were converted to primary amines by reaction with neat ethylenediamine and then
Autor:
Ole Hindsgaul, Vivekanand P. Kamath
Publikováno v:
Carbohydrate Research. 280:323-330