Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Vivek M. Philip"'
Autor:
Vivek M. Philip, Hao He, Michael C. Saul, Price E. Dickson, Jason A. Bubier, Elissa J. Chesler
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-8 (2023)
Abstract Brain transcriptional variation is a heritable trait that mediates complex behaviors, including addiction. Expression quantitative trait locus (eQTL) mapping reveals genomic regions harboring genetic variants that influence transcript abunda
Externí odkaz:
https://doaj.org/article/cd099f304859405393bcd6b6262c1d1e
Autor:
Abbas Raza, Sean A. Diehl, Dimitry N. Krementsov, Laure K. Case, Dawei Li, Jason Kost, Robyn L. Ball, Elissa J. Chesler, Vivek M. Philip, Rui Huang, Yan Chen, Runlin Ma, Anna L. Tyler, J. Matthew Mahoney, Elizabeth P. Blankenhorn, Cory Teuscher
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Mice with the histamine sensitization resistant alleles are still susceptible to histamine shock, with a locus on chromosome 6 associated with histamine sensitization reported.
Externí odkaz:
https://doaj.org/article/fc0123809ac846b9beb61338ed557c62
Autor:
Jared R. Bagley, Lauren S. Bailey, Leona H. Gagnon, Hao He, Vivek M. Philip, Laura G. Reinholdt, Lisa M. Tarantino, Elissa J. Chesler, James D. Jentsch
Publikováno v:
Addiction Neuroscience, Vol 4, Iss , Pp 100045- (2022)
Impulsive behavior and impulsivity are heritable phenotypes that are strongly associated with risk for substance use disorders. Identifying the neurogenetic mechanisms that influence impulsivity may also reveal novel biological insights into addictio
Externí odkaz:
https://doaj.org/article/8d7ae0d3eb4240ea808588b686a11961
Autor:
Sarah A. Schoenrock, Leona Gagnon, Ashley Olson, Michael Leonardo, Vivek M. Philip, Hao He, Laura G. Reinholdt, Stacey J. Sukoff Rizzo, James D. Jentsch, Elissa J. Chesler, Lisa M. Tarantino
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Cocaine use and overdose deaths attributed to cocaine have increased significantly in the United States in the last 10 years. Despite the prevalence of cocaine use disorder (CUD) and the personal and societal problems it presents, there are currently
Externí odkaz:
https://doaj.org/article/41d4f62f80874b009ee9b8e8ee035d32
Autor:
Jennifer K. Sargent, Mark A. Warner, Benjamin E. Low, William H. Schott, Todd Hoffert, David Coleman, Xing Yi Woo, Todd Sheridan, Sonia Erattupuzha, Philipp P. Henrich, Vivek M. Philip, Jeffrey H. Chuang, Michael V. Wiles, Muneer G. Hasham
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 9 (2022)
Externí odkaz:
https://doaj.org/article/cd0b8ed3add94265be8d44e04d45e0f5
Autor:
Sam-Moon Kim, Chelsea A. Vadnie, Vivek M. Philip, Leona H. Gagnon, Kodavali V. Chowdari, Elissa J. Chesler, Colleen A. McClung, Ryan W. Logan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Circadian variability is driven by genetics and Diversity Outbred (DO) mice is a powerful tool for examining the genetics of complex traits because their high genetic and phenotypic diversity compared to conventional mouse crosses. The DO po
Externí odkaz:
https://doaj.org/article/b12b457980724ac89299756c29d2f1e8
Autor:
Guillermo M. Alexander, Terry D. Heiman-Patterson, Frank Bearoff, Roger B. Sher, Laura Hennessy, Shannon Terek, Nicole Caccavo, Gregory A. Cox, Vivek M. Philip, Elizabeth A. Blankenhorn
Publikováno v:
PLoS ONE, Vol 17, Iss 9 (2022)
Amyotrophic lateral sclerosis (ALS) is the most common degenerative motor neuron disorder. Although most cases of ALS are sporadic, 5–10% of cases are familial, with mutations associated with over 40 genes. There is variation of ALS symptoms within
Externí odkaz:
https://doaj.org/article/c5e45c28b7ff4ee8a44b61046dc065b0
Autor:
Amy R. Dunn, Niran Hadad, Sarah M. Neuner, Ji-Gang Zhang, Vivek M. Philip, Logan Dumitrescu, Timothy J. Hohman, Jeremy H. Herskowitz, Kristen M. S. O’Connell, Catherine C. Kaczorowski
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Developing strategies to maintain cognitive health is critical to quality of life during aging. The basis of healthy cognitive aging is poorly understood; thus, it is difficult to predict who will have normal cognition later in life. Individuals may
Externí odkaz:
https://doaj.org/article/55c45b3c6f334db690a33914c1daf442
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Substance use disorders are prevalent and present a tremendous societal cost but the mechanisms underlying addiction behavior are poorly understood and few biological treatments exist. One strategy to identify novel molecular mechanisms of addiction
Externí odkaz:
https://doaj.org/article/dd4646bee8a64168a84671bcedca49fb
Autor:
Ying-Wooi Wan, Rami Al-Ouran, Carl G. Mangleburg, Thanneer M. Perumal, Tom V. Lee, Katherine Allison, Vivek Swarup, Cory C. Funk, Chris Gaiteri, Mariet Allen, Minghui Wang, Sarah M. Neuner, Catherine C. Kaczorowski, Vivek M. Philip, Gareth R. Howell, Heidi Martini-Stoica, Hui Zheng, Hongkang Mei, Xiaoyan Zhong, Jungwoo Wren Kim, Valina L. Dawson, Ted M. Dawson, Ping-Chieh Pao, Li-Huei Tsai, Jean-Vianney Haure-Mirande, Michelle E. Ehrlich, Paramita Chakrabarty, Yona Levites, Xue Wang, Eric B. Dammer, Gyan Srivastava, Sumit Mukherjee, Solveig K. Sieberts, Larsson Omberg, Kristen D. Dang, James A. Eddy, Phil Snyder, Yooree Chae, Sandeep Amberkar, Wenbin Wei, Winston Hide, Christoph Preuss, Ayla Ergun, Phillip J. Ebert, David C. Airey, Sara Mostafavi, Lei Yu, Hans-Ulrich Klein, Gregory W. Carter, David A. Collier, Todd E. Golde, Allan I. Levey, David A. Bennett, Karol Estrada, T. Matthew Townsend, Bin Zhang, Eric Schadt, Philip L. De Jager, Nathan D. Price, Nilüfer Ertekin-Taner, Zhandong Liu, Joshua M. Shulman, Lara M. Mangravite, Benjamin A. Logsdon
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107908- (2020)
Summary: We present a consensus atlas of the human brain transcriptome in Alzheimer’s disease (AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples. We discover 30 brain coexpression modules from seven regions as
Externí odkaz:
https://doaj.org/article/c0a8fce1711e4e8caa8aeb71e0b9458a