Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Vivek M Rangnekar"'
Autor:
Karine Z Oben, Beth W Gachuki, Sara S Alhakeem, Mary K McKenna, Ying Liang, Daret K St Clair, Vivek M Rangnekar, Subbarao Bondada
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169767 (2017)
An understanding of how each individual 5q chromosome critical deleted region (CDR) gene contributes to malignant transformation would foster the development of much needed targeted therapies for the treatment of therapy related myeloid neoplasms (t-
Externí odkaz:
https://doaj.org/article/4bcd361048fb4b30a37263d3c348d29a
Autor:
Karthikeyan Subburayan, Faisal Thayyullathil, Siraj Pallichankandy, Anees Rahman Cheratta, Ameer Alakkal, Mehar Sultana, Nizar Drou, Muhammad Arshad, L. Palanikumar, Mazin Magzoub, Vivek M. Rangnekar, Sehamuddin Galadari
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Ferroptosis is a unique iron-dependent form of non-apoptotic cell death characterized by devastating lipid peroxidation. Whilst growing evidence suggests that ferroptosis is a type of autophagy-dependent cell death, the underlying molecular
Externí odkaz:
https://doaj.org/article/b042898b09fd4d3082a06ae086a75503
Autor:
Shayan eSarkar, Sumeet eJain, Vineeta eRai, Dipak Kumar Sahoo, Sumita eRaha, Sujit eSuklabaidya, Shantibhushan eSenapati, Vivek M Rangnekar, Indu Bhushan Maiti, Nrisingha eDey
Publikováno v:
Frontiers in Plant Science, Vol 6 (2015)
The gene Par-4 (Prostate Apoptosis Response 4) was originally identified in prostate cancer cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic activity. Particularly, the SAC domain of Par-4 (SAC-Par-4) selectively
Externí odkaz:
https://doaj.org/article/18a64cd92ee648fba6af884626f5a4d6
Autor:
Anmi Jose, Pallavi Kulkarni, Jaya Thilakan, Murali Munisamy, Anvita Gupta Malhotra, Jitendra Singh, Ashok Kumar, Vivek M. Rangnekar, Neha Arya, Mahadev Rao
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-24 (2024)
Abstract Despite advancements in treatment protocols, cancer is one of the leading cause of deaths worldwide. Therefore, there is a need to identify newer and personalized therapeutic targets along with screening technologies to combat cancer. With t
Externí odkaz:
https://doaj.org/article/0e6245e997e244a0a3c9088ed927cc6b
Autor:
Damayanti Das Ghosh, Hannah McDonald, Rajeswari Dutta, Keerthana Krishnan, Jaya Thilakan, Manash K. Paul, Neha Arya, Mahadev Rao, Vivek M. Rangnekar
Publikováno v:
Cells, Vol 13, Iss 21, p 1785 (2024)
Non-small cell lung cancer (NSCLC) has established predictive biomarkers that enable decisions on treatment regimens for many patients. However, resistance to therapy is widespread. It is therefore essential to have a panel of molecular biomarkers th
Externí odkaz:
https://doaj.org/article/94bd03e134ca40ab8503cdd668fbc111
Autor:
James Sledziona, Ravshan Burikhanov, Nathalia Araujo, Jieyun Jiang, Nikhil Hebbar, Vivek M. Rangnekar
Publikováno v:
Cells, Vol 13, Iss 17, p 1495 (2024)
Prostate apoptosis response-4 (Par-4, also known as PAWR) is a ubiquitously expressed tumor suppressor protein that induces apoptosis selectively in cancer cells, while leaving normal cells unaffected. Our previous studies indicated that genetic loss
Externí odkaz:
https://doaj.org/article/392f32452a5943538017099d1fe8b91c
Autor:
Preetiparna Parida, Shirley Lewis, Krishna Sharan, Mehta Vedant Kamal, Naveena A. N. Kumar, Vishwapriya M. Godkhindi, Sooryanarayana Varambally, Vivek M. Rangnekar, Mahadev Rao, Rama Rao Damerla
Publikováno v:
Cells, Vol 12, Iss 21, p 2530 (2023)
C1orf74, also known as URCL4, has been reported to have higher expression and be associated with poor prognosis in lung adenocarcinoma patients, and its role in regulation of the EGFR/AKT/mTORC1 pathway has been recently elucidated. In the current st
Externí odkaz:
https://doaj.org/article/c1eab0dd1a784f15bb0f85ca18d31ead
Autor:
Jill Kolesar, Spencer Peh, Levin Thomas, Gayathri Baburaj, Nayonika Mukherjee, Raveena Kantamneni, Shirley Lewis, Ananth Pai, Karthik S. Udupa, Naveena Kumar AN, Vivek M. Rangnekar, Mahadev Rao
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-22 (2022)
Abstract The advent of molecular profiling has revolutionized the treatment of lung cancer by comprehensively delineating the genomic landscape of the epidermal growth factor receptor (EGFR) gene. Drug resistance caused by EGFR mutations and genetic
Externí odkaz:
https://doaj.org/article/1f5edd8ffa8246c4a8eba583dadef412
Autor:
Nathalia Araujo, James Sledziona, Sunil K. Noothi, Ravshan Burikhanov, Nikhil Hebbar, Saptadwipa Ganguly, Tripti Shrestha-Bhattarai, Beibei Zhu, Wendy S. Katz, Yi Zhang, Barry S. Taylor, Jinze Liu, Li Chen, Heidi L. Weiss, Daheng He, Chi Wang, Andrew J. Morris, Lisa A. Cassis, Mariana Nikolova-Karakashian, Prabhakar R. Nagareddy, Olle Melander, B. Mark Evers, Philip A. Kern, Vivek M. Rangnekar
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Prostate apoptosis response-4 (Par-4) is a tumor suppressor that induces apoptosis in cancer cells. However, the physiological function of Par-4 remains unknown. Here we show that conventional Par-4 knockout (Par-4-/-) mice and adipocyte-specific Par
Externí odkaz:
https://doaj.org/article/4120df1ef9614b949185e69e897e61c9
Autor:
Vivek M. Rangnekar, Kojo S.J. Elenitoba-Johnson, Yanming Zhao, Shirley Qiu, Nidhi Shukla, Ravshan Burikhanov, Nikhil Hebbar
SUPPLEMENTARY DATA (1) Figure S1 shows that Paclitaxel induces paracrine apoptosis in Paclitaxel-resistant cells by inducing the secretion of a Par-4-like secreted factor. (2) Figure S2 shows that Par-4 is cleaved to produce the 15 kDa fragment. (3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad73d02ed40d2ab034a607b10f4efb6
https://doi.org/10.1158/0008-5472.22414463
https://doi.org/10.1158/0008-5472.22414463
