Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Vivek K Vishnudas"'
Autor:
Heather E Arsenault, Julie M Ghizzoni, Cassandra M Leech, Anne R Diers, Stephane Gesta, Vivek K Vishnudas, Niven R Narain, Rangaprasad Sarangarajan, Jennifer A Benanti
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 12 (2021)
AbstractThe spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase. Activation of the spindle checkpoint results in inhibit
Externí odkaz:
https://doaj.org/article/925891e8da284d118b898b3fe1cf5c4a
Autor:
Khampaseuth Thapa, Kai Connie Wu, Aishwarya Sarma, Eric M. Grund, Angela Szeto, Armando J. Mendez, Stephane Gesta, Vivek K. Vishnudas, Niven R. Narain, Rangaprasad Sarangarajan
Publikováno v:
Cell & Bioscience, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Background Diabetes mellitus is associated with an increased risk in diabetic cardiomyopathy (DCM) that is distinctly not attributed to co-morbidities with other vasculature diseases. To date, while dysregulation of calcium handling is a key
Externí odkaz:
https://doaj.org/article/56b449c48fb14bcc80a8f66ce09979f5
Autor:
Enxuan Jing, Pragalath Sundararajan, Ishita Deb Majumdar, Suwagmani Hazarika, Samantha Fowler, Angela Szeto, Stephane Gesta, Armando J. Mendez, Vivek K. Vishnudas, Rangaprasad Sarangarajan, Niven R. Narain
Publikováno v:
Nutrition & Metabolism, Vol 15, Iss 1, Pp 1-10 (2018)
Abstract Background Inhibition of Hsp90 has been shown to improve glucose tolerance and insulin sensitivity in mouse models of diabetes. In the present report, the specific isoform Hsp90ab1, was identified as playing a major role in regulating insuli
Externí odkaz:
https://doaj.org/article/d75f9c8e8cd84ed48bbe767a8e883d40
Autor:
Jialiang Yang, Jacob Hagen, Kalyani V. Guntur, Kimaada Allette, Sarah Schuyler, Jyoti Ranjan, Francesca Petralia, Stephane Gesta, Robert Sebra, Milind Mahajan, Bin Zhang, Jun Zhu, Sander Houten, Andrew Kasarskis, Vivek K. Vishnudas, Viatcheslav R. Akmaev, Rangaprasad Sarangarajan, Niven R. Narain, Eric E. Schadt, Carmen A. Argmann, Zhidong Tu
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background Exosomes and other extracellular vesicles (EVs) have emerged as an important mechanism of cell-to-cell communication. However, previous studies either did not fully resolve what genetic materials were shuttled by exosomes or only
Externí odkaz:
https://doaj.org/article/0c940c9ca1524a2aba2cc141c228b9cc
Autor:
Louisa Dowal, Pooja Parameswaran, Sarah Phat, Syamala Akella, Ishita Deb Majumdar, Jyoti Ranjan, Chahan Shah, Saie Mogre, Kalyani Guntur, Khampaseuth Thapa, Stephane Gesta, Vivek K. Vishnudas, Niven R. Narain, Rangaprasad Sarangarajan
Publikováno v:
Mediators of Inflammation, Vol 2017 (2017)
Obesity is marked by chronic, low-grade inflammation. Here, we examined whether intrinsic differences between white and brown adipocytes influence the inflammatory status of macrophages. White and brown adipocytes were characterized by transcriptiona
Externí odkaz:
https://doaj.org/article/4440b470a131444c8abf9b4b553092fa
Autor:
Stephane Gesta, Jennifer A. Benanti, Niven R. Narain, Heather E. Arsenault, Anne R. Diers, Cassandra M. Leech, Julie M Ghizzoni, Vivek K. Vishnudas, Rangaprasad Sarangarajan
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 12 (2021)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
The spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase. Activation of the spindle checkpoint results in inhibition of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbfc468d5ce990fd8e80e59985e971b
https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkab346
https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkab346
Autor:
Jeremy Drolet, Vladimir Tolstikov, Brian A. Williams, Bennett P. Greenwood, Collin Hill, Vivek K. Vishnudas, Rangaprasad Sarangarajan, Niven R. Narain, Michael A. Kiebish
Publikováno v:
Metabolites, Vol 7, Iss 3, p 35 (2017)
(1) Background: Interest in the application of metabolomics toward clinical diagnostics development and population health monitoring has grown significantly in recent years. In spite of several advances in analytical and computational tools, obtainin
Externí odkaz:
https://doaj.org/article/f1bbf71e2a0244e88f2047bf739910f5
Autor:
Anne R. Diers, Vivek K. Vishnudas, Arindam Bose, Karl T. Diedrich, Shiva Kazerounian, Michael A. Kiebish, Manuel Hidalgo, Stephane Gesta, Carrie Spencer, Emily Y. Chen, Rangaprasad Sarangarajan, Fei Gao, Hannah E. Rockwell, Justice McDaniel, Vijetha Vemulapalli, Niven R. Narain, Pallavi Awate, Ryan Ng, Khampaseuth Thapa, A. James Moser, Saie Mogre, Senthil K. Muthuswamy, Viatcheslav R. Akmaev, Elder Granger, Katerina Krumova, Tulin Dadali, Leonardo O. Rodrigues
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
Reactive oxygen species (ROS) are implicated in triggering cell signalling events and pathways to promote and maintain tumorigenicity. Chemotherapy and radiation can induce ROS to elicit cell death allows for targeting ROS pathways for effective anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bac2498c8c00168a4b400dc264bc1d4
https://doi.org/10.1038/s41598-021-84852-z
https://doi.org/10.1038/s41598-021-84852-z
Autor:
Maria-Dorothea Nastke, Marisa Permatteo, Pragalath Sundararajan, Shefali Sharma, Jacob Matson, Kaleigh Gray, Arcan Guven, Shiva Kazerounian, Anne Diers, Rangaprasad Sarangarajan, Niven R. Narain, Vivek K. Vishnudas, Stephane Gesta
Publikováno v:
Cancer Research. 82:5321-5321
The ubiquitin-proteasome system (UPS) plays an important role in cellular processes for protein quality control and homeostasis and indeed, dysregulation within the pathway has implications in numerous diseases, especially cancer. Here, we introduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d58c14eb8a53b64204cd8f8d4b158e0
https://doi.org/10.1158/1538-7445.am2022-5321
https://doi.org/10.1158/1538-7445.am2022-5321
Autor:
Shiva Kazerounian, Mollie O'Hara, Arcan Guven, Kashni Grover, Nicole Pellegrino, Kayleigh Gray, Can Bruce, Gregory M. Miller, Maria-Dorothea Nastke, Michael A. Kiebish, Eric M. Grund, Rangaprasad Sarangarajan, Niven R. Narain, Stephane Gesta, Vivek K. Vishnudas
Publikováno v:
Cancer Research. 82:5320-5320
Gastric cancer is difficult to treat and exhibits poor survival with current therapies (five-year survival for all stages is 32% and 5% for metastatic gastric cancer) demonstrating a clear unmet clinical need. UBE2K was identified as a drug target fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::741db712a4431f2f26a077bd6e172985
https://doi.org/10.1158/1538-7445.am2022-5320
https://doi.org/10.1158/1538-7445.am2022-5320