Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Vivek J. Kadambi"'
Autor:
Mazin Derzi, Salima Darakjy, Nancy Bower, Daniel Lapadula, Vivek J. Kadambi, Akintunde Bello, James Hartke, F. Owen Fields, Aubrey Stoch, Maggie Liu, Judith S. Prescott
Publikováno v:
Clinical Pharmacology & Therapeutics. 107:514-520
A significant regulatory gap exists to facilitate global development of therapeutics for nononcology severely debilitating or life-threatening diseases or conditions (SDLTs). In a 2017 publication, a streamlined approach to the development of treatme
Autor:
Jean-Pierre Valentin, Lyn Rosenbrier-Ribeiro, Stephen Jenkinson, Jean-Michel Guillon, Sonia Roberts, Duncan Armstrong, Friedemann Schmidt, Vivek J. Kadambi, Peri Ravikumar
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 93:7-14
Introduction In 2015, IQ DruSafe conducted a survey of its membership to identify industry practices related to in vitro off target pharmacological profiling of small molecules. Methods An anonymous survey of 20 questions was submitted to IQ-DruSafe
Autor:
Todd B. Sells, Ryan Chau, Jeffrey A. Ecsedy, Rachel E. Gershman, Kara Hoar, Jessica Huck, David A. Janowick, Vivek J. Kadambi, Patrick J. LeRoy, Matthew Stirling, Stephen G. Stroud, Tricia J. Vos, Gabriel S. Weatherhead, Deborah R. Wysong, Mengkun Zhang, Suresh K. Balani, Joseph B. Bolen, Mark G. Manfredi, Christopher F. Claiborne
Publikováno v:
ACS Medicinal Chemistry Letters. 6:630-634
The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, select
Autor:
Thomas W. Jones, Timothy K. Hart, Maggie Liu, Michael W. Bolt, Donna Dambach, Vivek J. Kadambi, Douglas A. Keller, Thomas M. Monticello, David M. Potter
Publikováno v:
Toxicology and applied pharmacology. 334
The contribution of animal testing in drug development has been widely debated and challenged. An industry-wide nonclinical to clinical translational database was created to determine how safety assessments in animal models translate to First-In-Huma
Autor:
Vivek J. Kadambi, U. Iyer
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 64:207-212
Antibody drug conjugates (ADCs) consist of an antibody attached to a cytotoxic drug by means of a linker. ADCs provide a way to couple the specificity of a monoclonal antibody (mAb) to the cytotoxicity of a small-molecule drug and, therefore, are pro
Autor:
A. Lynn, Daniel Morton, Lee Silverman, Vivek J. Kadambi, A. Bourdeau, Frank D. Sistare, Carl L. Alden
Publikováno v:
Veterinary Pathology. 48:772-784
The pharmaceutical industry and regulatory agency toxicology testing paradigms in the United States currently appear successful, in part because of the continuously increasing life expectancy and the declining age-adjusted cancer rates in the United
Autor:
K. Cardoza, Vivek J. Kadambi, Arek Raczynski, E. Csizmadia, Lee Silverman, Carl L. Alden, Eric R. Fedyk, Chris Simpson, L. O’Brien, M. Gallacher, Vilmos Csizmadia
Publikováno v:
Veterinary Pathology. 47:358-367
Proteasome inhibitor therapeutics (PITs) have the potential to cause peripheral neuropathy. In a mouse model of PIT-induced peripheral neuropathy, the authors demonstrated that ubiquitin-positive multifocal protein aggregates with nuclear displacemen
Autor:
Brian D. Hoit, Richard A. Walsh, Raj Dash, Evangelia G. Kranias, Vivek J. Kadambi, Nancy Ball, Daniel A. Tramuta
Publikováno v:
Journal of Molecular and Cellular Cardiology. 31:2007-2015
Twelve mice with PLB overexpression (PLBOE), and 11 isogenic FVB/N wild-type (WT) controls, were anesthetized and instrumented with a 1.4 F Millar catheter in the LV and a 1 F pacemaker in the right atrium. At a cycle length of 200 ms and a fixed ext
Publikováno v:
Circulation Research. 84:360-364
Abstract —Vascular endothelial cells regulate vascular smooth muscle tone through Ca 2+ -dependent production and release of vasoactive molecules. Phospholamban (PLB) is a 24- to 27-kDa phosphoprotein that modulates activity of the sarco(endo)plasm
Autor:
Evangelia G. Kranias, Vivek J. Kadambi
Publikováno v:
Journal of Cardiac Failure. 4:349-361
The advent of mouse genetic manipulation coupled with the development of miniaturized technology to characterize the obtained phenotypes have provided significant insights into the genetic mechanisms underlying cardiovascular function in health and d