Aging and neurodegeneration are associated with increased mutations in single human neurons.

Autor: Lodato MA; Division of Genetics and Genomics, Manton Center for Orphan Disease, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.; Departments of Neurology and Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rodin RE; Division of Genetics and Genomics, Manton Center for Orphan Disease, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.; Departments of Neurology and Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Neuroscience and Harvard/MIT MD-PHD Program, Harvard Medical School, Boston, MA, USA., Bohrson CL; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Coulter ME; Division of Genetics and Genomics, Manton Center for Orphan Disease, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.; Departments of Neurology and Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Neuroscience and Harvard/MIT MD-PHD Program, Harvard Medical School, Boston, MA, USA., Barton AR; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Kwon M; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Sherman MA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Vitzthum CM; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Luquette LJ; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Yandava CN; Computational Statistics and Bioinformatics Group, Advanced Artificial Intelligence Research Laboratory, WuXi NextCODE, Cambridge, MA, USA., Yang P; Computational Statistics and Bioinformatics Group, Advanced Artificial Intelligence Research Laboratory, WuXi NextCODE, Cambridge, MA, USA., Chittenden TW; Computational Statistics and Bioinformatics Group, Advanced Artificial Intelligence Research Laboratory, WuXi NextCODE, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Hatem NE; Division of Genetics and Genomics, Manton Center for Orphan Disease, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.; Departments of Neurology and Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ryu SC; Division of Genetics and Genomics, Manton Center for Orphan Disease, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.; Departments of Neurology and Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Woodworth MB; Division of Genetics and Genomics, Manton Center for Orphan Disease, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.; Departments of Neurology and Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Park PJ; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. peter_park@hms.harvard.edu christopher.walsh@childrens.harvard.edu.; Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA., Walsh CA; Division of Genetics and Genomics, Manton Center for Orphan Disease, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA. peter_park@hms.harvard.edu christopher.walsh@childrens.harvard.edu.; Departments of Neurology and Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2018 Feb 02; Vol. 359 (6375), pp. 555-559. Date of Electronic Publication: 2017 Dec 07.