Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Vitya Vardanyan"'
Autor:
Magnus Chan, Harutyun Sahakyan, Jodene Eldstrom, Daniel Sastre, Yundi Wang, Ying Dou, Marc Pourrier, Vitya Vardanyan, David Fedida
Publikováno v:
eLife, Vol 12 (2023)
The cardiac IKs ion channel comprises KCNQ1, calmodulin, and KCNE1 in a dodecameric complex which provides a repolarizing current reserve at higher heart rates and protects from arrhythmia syndromes that cause fainting and sudden death. Pharmacologic
Externí odkaz:
https://doaj.org/article/972062197e2f4d61948dabb48632c42c
Autor:
Niklas Schütter, Yuri Correia Barreto, Vitya Vardanyan, Sönke Hornig, Stephen Hyslop, Sérgio Marangoni, Léa Rodrigues-Simioni, Olaf Pongs, Cháriston André Dal Belo
Publikováno v:
Toxins, Vol 11, Iss 6, p 335 (2019)
MiDCA1, a phospholipase A2 (PLA2) neurotoxin isolated from Micrurus dumerilii carinicauda coral snake venom, inhibited a major component of voltage-activated potassium (Kv) currents (41 ± 3% inhibition with 1 μM toxin) in mouse cultured dorsal root
Externí odkaz:
https://doaj.org/article/71016df68b4f4dc0984c9567cd98919c
Autor:
Astghik Abrahamyan, Jodene Eldstrom, Harutyun Sahakyan, Nare Karagulyan, Liana Mkrtchyan, Tatev Karapetyan, Ernest Sargsyan, Matthias Kneussel, Karen Nazaryan, Jürgen R. Schwarz, David Fedida, Vitya Vardanyan
Publikováno v:
Journal of General Physiology. 155
KCNQ1 voltage-gated K+ channels are involved in a wide variety of fundamental physiological processes and exhibit the unique feature of being markedly inhibited by external K+. Despite the potential role of this regulatory mechanism in distinct physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02aead83fc429d419d5fd0ebbb54d45c
https://doi.org/10.1085/jgp.202213205
https://doi.org/10.1085/jgp.202213205
Publikováno v:
Biophysical Journal. 100(4):885-894
Controlled opening and closing of an ion-selective pathway in response to changes of membrane potential is a fundamental feature of voltage-gated ion channels. In recent decades, various details of this process have been revealed with unprecedented p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d997281704190ede397b8803a99493
Autor:
Robert Bähring, Lijuan Ma, Yingxue Dong, Yanzong Yang, Jue Ye, Olaf Pongs, Rutai Hui, Chunxia Lin, Zhi-hu Lin, Vitya Vardanyan, Siyong Teng
Publikováno v:
Journal of Molecular Medicine. 82:189-196
We have found a novel nonsense mutation in the C-terminus of HERG in a four-generation Chinese family with long QT syndrome and investigated the molecular mechanism of this mutation in vitro. Six family members, including the proband, were clinically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b2bf5b4fdfcc568d613da98fc8a9a3
https://doi.org/10.1007/s00109-003-0504-1
https://doi.org/10.1007/s00109-003-0504-1
Publikováno v:
Molecular Membrane Biology. 21:19-25
The effect of Kvbeta3 subunit co-expression on currents mediated by the Shaker-related channels Kv1.1 to Kv1.6 in Chinese hamster ovary (CHO) cells was studied with patch-clamp techniques. In the presence of Kvbeta3, differences in the voltage depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac410828e1bb0e8a23de00524351aeb5
https://doi.org/10.1080/09687680310001597749
https://doi.org/10.1080/09687680310001597749
Autor:
Lijuan Ma, Liang Li, Olaf Pongs, Rutai Hui, Chunxia Lin, Vitya Vardanyan, Robert Bähring, Siyong Teng, Yongping Chai
Publikováno v:
Cardiovascular Research. 59:612-619
Objectives: To identify the underlying genetic basis of a Chinese pedigree with Long QT syndrome, the causally related genes were screened in a family and the functional consequence of the identified gene mutation was evaluated in vitro. Methods: Mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e815f471dd4d995b7b5acf04060a84f
https://doi.org/10.1016/s0008-6363(03)00510-8
https://doi.org/10.1016/s0008-6363(03)00510-8
Autor:
Chunxia Lin, Yisong Zhen, Robert Bähring, Vitya Vardanyan, Lijuan Ma, Olaf Pongs, Rutai Hui, Siyong Teng
Publikováno v:
Biochemical and Biophysical Research Communications. 303:808-813
The KCNE genes encode small, single transmembrane domain peptides that associate with pore-forming potassium channel subunits to form mixed complexes with unique characteristics. We have identified a novel member of the human KCNE gene family, hKCNE4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bde7dfe55ccdb8f3fbbaac2ef0a2bed
https://doi.org/10.1016/s0006-291x(03)00433-9
https://doi.org/10.1016/s0006-291x(03)00433-9
Autor:
Vitya Vardanyan
Publikováno v:
Biophysical Journal. 98(3)
The response of voltage-dependent K+ (Kv) channels to a change in membrane voltage involves a molecular device, which couples voltage-driven conformational changes to gate opening and closing within the channel's conduction pathway. To further our un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420b8d6defc7a7f8303f06ae80d9ff3f
Autor:
Vitya Vardanyan, Sönke Hornig, Karin Giller, Phanindra Velisetty, Olaf Pongs, Marc Baldus, Iris Ohmert, Stefan Becker, Robert Schneider, Christian Ader
Potassium (K(+))-channel gating is choreographed by a complex interplay between external stimuli, K(+) concentration and lipidic environment. We combined solid-state NMR and electrophysiological experiments on a chimeric KcsA-Kv1.3 channel to delinea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae88c9429920dc213e47e53a49382b3
https://dspace.library.uu.nl/handle/1874/44415
https://dspace.library.uu.nl/handle/1874/44415
