Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Vittorio Sebastiano"'
Autor:
Andrea Cipriano, Alessio Colantoni, Alessandro Calicchio, Jonathan Fiorentino, Danielle Gomes, Mahdi Moqri, Alexander Parker, Sajede Rasouli, Matthew Caldwell, Francesca Briganti, Maria Grazia Roncarolo, Antonio Baldini, Katja G. Weinacht, Gian Gaetano Tartaglia, Vittorio Sebastiano
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-39 (2024)
Abstract Background The Pharyngeal Endoderm (PE) is an extremely relevant developmental tissue, serving as the progenitor for the esophagus, parathyroids, thyroids, lungs, and thymus. While several studies have highlighted the importance of PE cells,
Externí odkaz:
https://doaj.org/article/f51958fa58764091b1141540dff228c9
Autor:
Mahdi Moqri, Andrea Cipriano, Daniel J. Simpson, Sajede Rasouli, Tara Murty, Tineke Anna de Jong, Daniel Nachun, Guilherme de Sena Brandine, Kejun Ying, Andrei Tarkhov, Karolina A. Aberg, Edwin van den Oord, Wanding Zhou, Andrew Smith, Crystal Mackall, Vadim N. Gladyshev, Steve Horvath, Michael P. Snyder, Vittorio Sebastiano
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract DNA methylation (DNAm) is one of the most reliable biomarkers of aging across mammalian tissues. While the age-dependent global loss of DNAm has been well characterized, DNAm gain is less characterized. Studies have demonstrated that CpGs wh
Externí odkaz:
https://doaj.org/article/903dd1a324284990bb38ba6fe77d4c37
Autor:
Sivakamasundari Vijayakumar, Roberta Sala, Gugene Kang, Angela Chen, Michelle Ann Pablo, Abidemi Ismail Adebayo, Andrea Cipriano, Jonas L. Fowler, Danielle L. Gomes, Lay Teng Ang, Kyle M. Loh, Vittorio Sebastiano
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Generating primordial germ cell-like cells (PGCLCs) from human pluripotent stem cells (hPSCs) advances studies of human reproduction and development of infertility treatments, but often entails complex 3D aggregates. Here we develop a simpli
Externí odkaz:
https://doaj.org/article/8e8d0192fda64084872f8d3b27e40339
Autor:
Miguel Angel Brieño-Enriquez, Francesca E. Duncan, Arjumand Ghazi, Michael Klutstein, Vittorio Sebastiano, Jessica Tyler
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/2937b91e6a4a44d69446dc320dee1efc
Autor:
Tapash Jay Sarkar, Marco Quarta, Shravani Mukherjee, Alex Colville, Patrick Paine, Linda Doan, Christopher M. Tran, Constance R. Chu, Steve Horvath, Lei S. Qi, Nidhi Bhutani, Thomas A. Rando, Vittorio Sebastiano
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Aging involves gradual loss of tissue function, and transcription factor (TF) expression can ameliorate this in progeroid mice. Here the authors show that transient TF expression reverses age-associated epigenetic marks, inflammatory profiles and res
Externí odkaz:
https://doaj.org/article/b88ee3f2918443da9a944c8371cd034e
Autor:
Derrick C. Wan, Stefanie L. Morgan, Andrew L. Spencley, Natasha Mariano, Erin Y. Chang, Gautam Shankar, Yunhai Luo, Ted H. Li, Dana Huh, Star K. Huynh, Jasmine M. Garcia, Cole M. Dovey, Jennifer Lumb, Ling Liu, Katharine V. Brown, Abel Bermudez, Richard Luong, Hong Zeng, Victoria L. Mascetti, Sharon J. Pitteri, Jordon Wang, Hua Tu, Marco Quarta, Vittorio Sebastiano, Roel Nusse, Thomas A. Rando, Jan E. Carette, J. Fernando Bazan, Kevin C. Wang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Royal jelly is the queen-maker for the honey bee that also has effects on longevity, fertility, and regeneration in mammals. Here the authors provide evidence that its major protein component Royalactin, and the mammalian structural analog Regina, ma
Externí odkaz:
https://doaj.org/article/6ac458ba736146368698999f73b60666
Autor:
Fang Fang, Ninuo Xia, Benjamin Angulo, Joseph Carey, Zackery Cady, Jens Durruthy-Durruthy, Theo Bennett, Vittorio Sebastiano, Renee A. Reijo Pera
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Self-renewal and pluripotency of human embryonic stem cells (hESCs) depends upon the function of the transcription factor OCT4. Here, the authors identified proteins associated with the OCT4 enhancer, notably ZNF207 that maintains both pluripotency a
Externí odkaz:
https://doaj.org/article/a35e6e487bc6412fa338cd4e9f76670f
Autor:
Jeewon Kim, Amirali Afshari, Ranjita Sengupta, Vittorio Sebastiano, Archana Gupta, Young H Kim, Reproducibility Project: Cancer Biology
Publikováno v:
eLife, Vol 7 (2018)
As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Lesnik et al., 2016) that described how we intended to replicate selected experiments from the paper ‘Melanoma exosomes educate bone marrow progenitor cells to
Externí odkaz:
https://doaj.org/article/11aacac91648440d8eebf1ecd948b469
Autor:
Han Qin, Miroslav Hejna, Yanxia Liu, Michelle Percharde, Mark Wossidlo, Laure Blouin, Jens Durruthy-Durruthy, Priscilla Wong, Zhongxia Qi, Jingwei Yu, Lei S. Qi, Vittorio Sebastiano, Jun S. Song, Miguel Ramalho-Santos
Publikováno v:
Cell Reports, Vol 14, Iss 10, Pp 2301-2312 (2016)
The human naive pluripotent stem cell (PSC) state, corresponding to a pre-implantation stage of development, has been difficult to capture and sustain in vitro. We report that the Hippo pathway effector YAP is nuclearly localized in the inner cell ma
Externí odkaz:
https://doaj.org/article/2128dba65f7d4003891ad45c8f7bc635
Autor:
Gennadi Glinsky, Jens Durruthy-Durruthy, Mark Wossidlo, Edward J. Grow, Jason L. Weirather, Kin Fai Au, Joanna Wysocka, Vittorio Sebastiano
Publikováno v:
Heliyon, Vol 4, Iss 6, Pp e00667- (2018)
Chromosome instability and aneuploidies occur very frequently in human embryos, impairing proper embryogenesis and leading to cell cycle arrest, loss of cell viability, and developmental failures in 50–80% of cleavage-stage embryos. This high frequ
Externí odkaz:
https://doaj.org/article/9866509ff21a4a32975ab6658cc2cdc1