Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Vittorio Maglione"'
Autor:
Giorgia Maria Ferlazzo, Anna Maria Gambetta, Sonia Amato, Noemi Cannizzaro, Silvia Angiolillo, Mattia Arboit, Linda Diamante, Elena Carbognin, Patrizia Romani, Federico La Torre, Elena Galimberti, Florian Pflug, Mirko Luoni, Serena Giannelli, Giuseppe Pepe, Luca Capocci, Alba Di Pardo, Paola Vanzani, Lucio Zennaro, Vania Broccoli, Martin Leeb, Enrico Moro, Vittorio Maglione, Graziano Martello
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Huntington’s disease (HD) is a neurodegenerative disorder caused by CAG-repeat expansions in the huntingtin (HTT) gene. The resulting mutant HTT (mHTT) protein induces toxicity and cell death via multiple mechanisms and no effective therap
Externí odkaz:
https://doaj.org/article/c1ac1fcec269480f96fa0a3e4fd588a3
Autor:
Johannes Burtscher, Barbara Strasser, Giuseppe Pepe, Martin Burtscher, Martin Kopp, Alba Di Pardo, Vittorio Maglione, Andy V. Khamoui
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4696 (2024)
Prominent pathological features of Huntington’s disease (HD) are aggregations of mutated Huntingtin protein (mHtt) in the brain and neurodegeneration, which causes characteristic motor (such as chorea and dystonia) and non-motor symptoms. However,
Externí odkaz:
https://doaj.org/article/fa664a9535894977a22ac1a6be20f4ae
Autor:
Maurizio Forte, Franca Bianchi, Maria Cotugno, Simona Marchitti, Rosita Stanzione, Vittorio Maglione, Sebastiano Sciarretta, Valentina Valenti, Roberto Carnevale, Francesco Versaci, Giacomo Frati, Massimo Volpe, Speranza Rubattu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-12 (2021)
Abstract The mitochondrial uncoupling protein 2 (UCP2) plays a protective function in the vascular disease of both animal models and humans. UCP2 downregulation upon high-salt feeding favors vascular dysfunction in knock-out mice, and accelerates cer
Externí odkaz:
https://doaj.org/article/d1968d31bf4c4de3b41dafd6f34d0fda
Autor:
Giuseppe Pepe, Salvatore Fioriniello, Federico Marracino, Luca Capocci, Vittorio Maglione, Maurizio D’Esposito, Alba Di Pardo, Floriana Della Ragione
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 606 (2023)
Rett syndrome (RTT, online MIM 312750) is a devastating neurodevelopmental disorder characterized by motor and cognitive disabilities. It is mainly caused by pathogenetic variants in the X-linked MECP2 gene, encoding an epigenetic factor crucial for
Externí odkaz:
https://doaj.org/article/f8b13bb92ed44651b12c02824c1dd910
Autor:
Giuseppe Pepe, Paola Lenzi, Luca Capocci, Federico Marracino, Ludovica Pizzati, Pamela Scarselli, Alba Di Pardo, Francesco Fornai, Vittorio Maglione
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5956 (2023)
Huntington’s disease is one of the most common dominantly inherited neurodegenerative disorders caused by an expansion of a polyglutamine (polyQ) stretch in the N-terminal region of huntingtin (Htt). Among all the molecular mechanisms, affected by
Externí odkaz:
https://doaj.org/article/7662e0065e72414aae69dee8d642b03b
Autor:
Paolo Rosa, Sofia Scibetta, Giuseppe Pepe, Giorgio Mangino, Luca Capocci, Sam J. Moons, Thomas J. Boltje, Francesco Fazi, Vincenzo Petrozza, Alba Di Pardo, Vittorio Maglione, Antonella Calogero
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9563 (2022)
Gliomas are the most common primary malignant brain tumors. Glioblastoma, IDH-wildtype (GBM, CNS WHO grade 4) is the most aggressive form of glioma and is characterized by extensive hypoxic areas that strongly correlate with tumor malignancy. Hypoxia
Externí odkaz:
https://doaj.org/article/ca29d9e96dad4387b51955dceb4fc20a
Autor:
Francesco Di Meo, Stefania Filosa, Michele Madonna, Gerarda Giello, Alba Di Pardo, Vittorio Maglione, Alfonso Baldi, Stefania Crispi
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-11 (2019)
Abstract Background A major limitation in the treatment for malignant mesothelioma is related to serious side effects caused by chemotherapeutics and to the development of cancer-resistance. Advances in cancer therapies have been reached thanks to th
Externí odkaz:
https://doaj.org/article/beb69be76020412e8c356970f43f5baa
Autor:
Johannes Burtscher, Giuseppe Pepe, Federico Marracino, Luca Capocci, Susy Giova, Grégoire P. Millet, Alba Di Pardo, Vittorio Maglione
Publikováno v:
Brain Sciences, Vol 11, Iss 10, p 1267 (2021)
Huntington’s disease (HD) is a rare hereditary neurodegenerative disorder characterized by multiple metabolic dysfunctions including defects in mitochondrial homeostasis and functions. Although we have recently reported age-related changes in the r
Externí odkaz:
https://doaj.org/article/a92bf5238b7f488aabdd4a42fc35ec97
Autor:
Alessandra Mingione, Francesca Pivari, Nicoletta Plotegher, Michele Dei Cas, Aida Zulueta, Tommaso Bocci, Marco Trinchera, Elisabetta Albi, Vittorio Maglione, Anna Caretti, Luigi Bubacco, Rita Paroni, Daniele Bottai, Riccardo Ghidoni, Paola Signorelli
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6469 (2021)
Parkinson’s disease (PD) is a proteinopathy associated with the aggregation of α-synuclein and the formation of lipid–protein cellular inclusions, named Lewy bodies (LBs). LB formation results in impaired neurotransmitter release and uptake, whi
Externí odkaz:
https://doaj.org/article/1c3a7d8ac9114d9f9af011b484954eba
Autor:
Alba Di Pardo, Enrico Amico, Abdul Basit, Andrea Armirotti, Piyush Joshi, M. Diana Neely, Romina Vuono, Salvatore Castaldo, Anna F. Digilio, Francesco Scalabrì, Giuseppe Pepe, Francesca Elifani, Michele Madonna, Se Kyoo Jeong, Bu-Mahn Park, Maurizio D’Esposito, Aaron B. Bowman, Roger A. Barker, Vittorio Maglione
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Huntington’s disease is characterized by a complex and heterogeneous pathogenic profile. Studies have shown that disturbance in lipid homeostasis may represent a critical determinant in the progression of several neurodegenerative disorder
Externí odkaz:
https://doaj.org/article/bf0f9516edd7471585e05c6cc1d03c10