Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Vittorio Fortino"'
Autor:
Otto Jokelainen, Teemu J. Rintala, Vittorio Fortino, Sanna Pasonen-Seppänen, Reijo Sironen, Timo K. Nykopp
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Hyaluronan (HA) accumulation in clear cell renal cell carcinoma (ccRCC) is associated with poor prognosis; however, its biology and role in tumorigenesis are unknown. RNA sequencing of 48 HA-positive and 48 HA-negative formalin-fixed paraffi
Externí odkaz:
https://doaj.org/article/776aee6536f440339bfd5fe199ef45b8
Autor:
Teemu J Rintala, Vittorio Fortino
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 8, p e1012275 (2024)
Recent research on multi-view clustering algorithms for complex disease subtyping often overlooks aspects like clustering stability and critical assessment of prognostic relevance. Furthermore, current frameworks do not allow for a comparison between
Externí odkaz:
https://doaj.org/article/ce6675965aa44d4084c3f1893e467653
Autor:
Antonio Federico, Lena Möbus, Zeyad Al-Abdulraheem, Alisa Pavel, Vittorio Fortino, Giusy del Giudice, Harri Alenius, Nanna Fyhrquist, Dario Greco
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease whose pathophysiology involves the interplay between genetic and environmental factors, ultimately leading to dysfunction of the epidermis. While several trea
Externí odkaz:
https://doaj.org/article/8b2ab85eecfc497e92b3317b3f61f1f0
Autor:
Antonio Federico, Alisa Pavel, Lena Möbus, David McKean, Giusy del Giudice, Vittorio Fortino, Hanna Niehues, Joe Rastrick, Kilian Eyerich, Stefanie Eyerich, Ellen van den Bogaard, Catherine Smith, Stephan Weidinger, Emanuele de Rinaldis, Dario Greco
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-16 (2022)
Abstract In recent years, a growing interest in the characterization of the molecular basis of psoriasis has been observed. However, despite the availability of a large amount of molecular data, many pathogenic mechanisms of psoriasis are still poorl
Externí odkaz:
https://doaj.org/article/8473f595cc8244e4b27dafb8dc20816a
Autor:
Vittorio Fortino, Pia Anneli Sofia Kinaret, Michele Fratello, Angela Serra, Laura Aliisa Saarimäki, Audrey Gallud, Govind Gupta, Gerard Vales, Manuel Correia, Omid Rasool, Jimmy Ytterberg, Marco Monopoli, Tiina Skoog, Peter Ritchie, Sergio Moya, Socorro Vázquez-Campos, Richard Handy, Roland Grafström, Lang Tran, Roman Zubarev, Riitta Lahesmaa, Kenneth Dawson, Katrin Loeschner, Erik Husfeldt Larsen, Fritz Krombach, Hannu Norppa, Juha Kere, Kai Savolainen, Harri Alenius, Bengt Fadeel, Dario Greco
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Nanomaterials have a range of potential applications, however, toxicity remains a concern, limiting application and requiring extensive testing. Here, the authors report on a predictive framework made using a range of tests linking materials properti
Externí odkaz:
https://doaj.org/article/cd868a81e9ec4d95b4b5c073cf9197e3
Autor:
Angela Serra, Laura Aliisa Saarimäki, Alisa Pavel, Giusy del Giudice, Michele Fratello, Luca Cattelani, Antonio Federico, Omar Laurino, Veer Singh Marwah, Vittorio Fortino, Giovanni Scala, Pia Anneli Sofia Kinaret, Dario Greco
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1413-1426 (2022)
The recent advancements in toxicogenomics have led to the availability of large omics data sets, representing the starting point for studying the exposure mechanism of action and identifying candidate biomarkers for toxicity prediction. The current l
Externí odkaz:
https://doaj.org/article/7024c22e1ca4432d9e811816d36ed4d3
Autor:
Marit Ilves, Pia Anneli Sofia Kinaret, Joseph Ndika, Piia Karisola, Veer Marwah, Vittorio Fortino, Yuri Fedutik, Manuel Correia, Nicky Ehrlich, Katrin Loeschner, Alexandros Besinis, Joanne Vassallo, Richard D. Handy, Henrik Wolff, Kai Savolainen, Dario Greco, Harri Alenius
Publikováno v:
Particle and Fibre Toxicology, Vol 16, Iss 1, Pp 1-21 (2019)
Abstract Background Copper oxide (CuO) nanomaterials are used in a wide range of industrial and commercial applications. These materials can be hazardous, especially if they are inhaled. As a result, the pulmonary effects of CuO nanomaterials have be
Externí odkaz:
https://doaj.org/article/d1f4557fd75142379a72a7396d13505f
Characterization of ENM Dynamic Dose-Dependent MOA in Lung with Respect to Immune Cells Infiltration
Autor:
Angela Serra, Giusy del Giudice, Pia Anneli Sofia Kinaret, Laura Aliisa Saarimäki, Sarah Søs Poulsen, Vittorio Fortino, Sabina Halappanavar, Ulla Vogel, Dario Greco
Publikováno v:
Nanomaterials, Vol 12, Iss 12, p 2031 (2022)
The molecular effects of exposures to engineered nanomaterials (ENMs) are still largely unknown. In classical inhalation toxicology, cell composition of bronchoalveolar lavage (BAL) is a toxicity indicator at the lung tissue level that can aid in int
Externí odkaz:
https://doaj.org/article/ffdf5fe19a2a4048b4105c7d488b2da9
Autor:
Audrey Gallud, Mathilde Delaval, Pia Kinaret, Veer Singh Marwah, Vittorio Fortino, Jimmy Ytterberg, Roman Zubarev, Tiina Skoog, Juha Kere, Manuel Correia, Katrin Loeschner, Zahraa Al‐Ahmady, Kostas Kostarelos, Jaime Ruiz, Didier Astruc, Marco Monopoli, Richard Handy, Sergio Moya, Kai Savolainen, Harri Alenius, Dario Greco, Bengt Fadeel
Publikováno v:
Advanced Science, Vol 7, Iss 22, Pp n/a-n/a (2020)
Abstract Despite considerable efforts, the properties that drive the cytotoxicity of engineered nanomaterials (ENMs) remain poorly understood. Here, the authors inverstigate a panel of 31 ENMs with different core chemistries and a variety of surface
Externí odkaz:
https://doaj.org/article/9a314f0b95114c6db6bf9e1d60d4034a
Autor:
Antonio Federico, Michele Fratello, Giovanni Scala, Lena Möbus, Alisa Pavel, Giusy del Giudice, Michele Ceccarelli, Valerio Costa, Alfredo Ciccodicola, Vittorio Fortino, Angela Serra, Dario Greco
Publikováno v:
Cancers, Vol 14, Iss 8, p 2043 (2022)
Despite remarkable efforts of computational and predictive pharmacology to improve therapeutic strategies for complex diseases, only in a few cases have the predictions been eventually employed in the clinics. One of the reasons behind this drawback
Externí odkaz:
https://doaj.org/article/5c67a8794a0a42b389948ece19b8b56a