Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Vittorio, de Franciscis"'
Autor:
Christopher J. LaFargue, Paola Amero, Kyunghee Noh, Lingegowda S. Mangala, Yunfei Wen, Emine Bayraktar, Sujanitha Umamaheswaran, Elaine Stur, Santosh K. Dasari, Cristina Ivan, Sunila Pradeep, Wonbeak Yoo, Chunhua Lu, Nicholas B. Jennings, Vinod Vathipadiekal, Wei Hu, Anca Chelariu-Raicu, Zhiqiang Ku, Hui Deng, Wei Xiong, Hyun-Jin Choi, Min Hu, Takae Kiyama, Chai-An Mao, Rouba Ali-Fehmi, Michael J. Birrer, Jinsong Liu, Ningyan Zhang, Gabriel Lopez-Berestein, Vittorio de Franciscis, Zhiqiang An, Anil K. Sood
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Antiangiogenic treatment targeting the vascular endothelial growth factor (VEGF) pathway is a powerful tool to combat tumor growth and progression; however, drug resistance frequently emerges. We identify CD5L (CD5 antigen-like precursor) as
Externí odkaz:
https://doaj.org/article/a4cffeff90ca418b8ed9c213a7bf3531
Autor:
Carla L. Esposito, Ida Autiero, Annamaria Sandomenico, H. Li, Mahmoud A. Bassal, Maria L. Ibba, Dongfang Wang, Lucrezia Rinaldi, Simone Ummarino, Giulia Gaggi, Marta Borchiellini, Piotr Swiderski, Menotti Ruvo, Silvia Catuogno, Alexander K. Ebralidze, Marcin Kortylewski, Vittorio de Franciscis, Annalisa Di Ruscio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Here the authors generate an RNA-based platform to neutralize the major epigenetic player DNMT1. Using this targeted approach, aberrant DNA methylation in cancer can be corrected.
Externí odkaz:
https://doaj.org/article/1ac7b00822ad42efaffe5d498c64c726
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 384-386 (2022)
Aptamers are RNAs that can bind proteins directly and modulate protein-protein interactions. Given their therapeutic potential, aptamers would be expected to capture the interest of both scientists and investors. However, concerns regarding safety, e
Externí odkaz:
https://doaj.org/article/c8935701525c40f489e850816443692c
Autor:
Carla Lucia Esposito, Cristina Quintavalle, Francesco Ingenito, Deborah Rotoli, Giuseppina Roscigno, Silvia Nuzzo, Renato Thomas, Silvia Catuogno, Vittorio de Franciscis, Gerolama Condorelli
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 982-994 (2021)
Breast cancer is a leading cause of cancer mortality in women. Despite advances in its management, the identification of new options for early-stage diagnosis and therapy of this tumor still represents a crucial challenge. Increasing evidence indicat
Externí odkaz:
https://doaj.org/article/c40392047de44fa0975ab4413f89e90d
Autor:
Alessandra Affinito, Cristina Quintavalle, Carla Lucia Esposito, Giuseppina Roscigno, Claudia Vilardo, Silvia Nuzzo, Lucia Ricci-Vitiani, Gabriele De Luca, Roberto Pallini, Anna S. Kichkailo, Ivan N. Lapin, Vittorio de Franciscis, Gerolama Condorelli
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 99-109 (2019)
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults. Despite progress in surgical and medical neuro-oncology, prognosis for GBM patients remains dismal, with a median survival of only 14–15 months. The modest benefit of conventi
Externí odkaz:
https://doaj.org/article/7de61e5fb69646a89fca5cc890fe7881
Autor:
Silvia Catuogno, Maria Teresa Di Martino, Silvia Nuzzo, Carla Lucia Esposito, Pierfrancesco Tassone, Vittorio de Franciscis
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 981-990 (2019)
B cell maturation antigen is highly expressed on malignant plasma cells in human multiple myeloma and has recently emerged as a very promising target for therapeutic interventions. Nucleic-acid-based aptamers are small oligonucleotides with high sele
Externí odkaz:
https://doaj.org/article/6eacff4f6e0b4359b5b19cd23eba5f0f
Autor:
Valentina Russo, Alessia Paciocco, Alessandra Affinito, Giuseppina Roscigno, Danilo Fiore, Francesco Palma, Marco Galasso, Stefano Volinia, Alfonso Fiorelli, Carla Lucia Esposito, Silvia Nuzzo, Giorgio Inghirami, Vittorio de Franciscis, Gerolama Condorelli
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 334-346 (2018)
MicroRNAs (miRNAs) are key regulators of different human processes that represent a new promising class of cancer therapeutics or therapeutic targets. Indeed, in several tumor types, including non-small-cell lung carcinoma (NSCLC), the deregulated ex
Externí odkaz:
https://doaj.org/article/c076190e86e845b698c2077731266200
Autor:
Carla Lucia Esposito, Silvia Nuzzo, Silvia Catuogno, Simona Romano, Filomena de Nigris, Vittorio de Franciscis
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 10, Iss , Pp 398-411 (2018)
Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor in adults, and despite advances in neuro-oncology, the prognosis for patients remains dismal. The signal transducer and activator of transcription-3 (STAT3) has been reported
Externí odkaz:
https://doaj.org/article/4282b9f693a6471598054e72cc554a78
Autor:
Carla L. Esposito, Katrien Van Roosbroeck, Gianluca Santamaria, Deborah Rotoli, Annamaria Sandomenico, William G. Wierda, Alessandra Ferrajoli, Menotti Ruvo, George A. Calin, Vittorio de Franciscis, Silvia Catuogno
Publikováno v:
Cancers, Vol 13, Iss 20, p 5220 (2021)
The transmembrane glycoprotein cluster of differentiation 19 (CD19) is a B cell–specific surface marker, expressed on the majority of neoplastic B cells, and has recently emerged as a very attractive biomarker and therapeutic target for B-cell mali
Externí odkaz:
https://doaj.org/article/bec828a0b55e41e0a65683a2c208977a
Autor:
Pinar Kanlikilicer, Bulent Ozpolat, Burcu Aslan, Recep Bayraktar, Nilgun Gurbuz, Cristian Rodriguez-Aguayo, Emine Bayraktar, Merve Denizli, Vianey Gonzalez-Villasana, Cristina Ivan, Ganesh L.R. Lokesh, Paola Amero, Silvia Catuogno, Monika Haemmerle, Sherry Yen-Yao Wu, Rahul Mitra, David G. Gorenstein, David E. Volk, Vittorio de Franciscis, Anil K. Sood, Gabriel Lopez-Berestein
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 251-262 (2017)
Despite substantial improvements in the treatment strategies, ovarian cancer is still the most lethal gynecological malignancy. Identification of drug treatable therapeutic targets and their safe and effective targeting is critical to improve patient
Externí odkaz:
https://doaj.org/article/30d18358dbe6414f995427ef4aed9541