A novel benzodiazepine derivative that suppresses microtubule dynamics and impairs mitotic progression

Autor: Siou Ku, Mathieu Métivier, Emmanuel Gallaud, Vittoria Pirani, Alexandre Thomas, Denis Chrétien, Lorenzo Corsi, Christelle Benaud, Régis Giet, Roberta Ettari

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2020, 133 (7), pp.jcs239244. ⟨10.1242/jcs.239244⟩
Journal of Cell Science, 2020, 133 (7), pp.jcs239244. ⟨10.1242/jcs.239244⟩

International audience; A novel 2,3-benzodiazepine-4 derivative, named 1g, has recently been shown to function as an anti-proliferative compound. We now show that it perturbs the formation of a functional mitotic spindle, inducing a spindle assembly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0440ebddcc53d74dfe2ba665936dd3ba
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02543756