Výsledky vyhledávání - "Vittoria Coppola"

Extreme assay sensitivity in molecular diagnostics further unveils intratumour heterogeneity in metastatic colorectal cancer as well as artifactual low-frequency mutations in the KRAS gene

Autor: Anna Sapino, Simona Osella-Abate, Cristiana Di Bello, Vittoria Coppola, Caterina Marchiò, Paola Francia di Celle, Paola Cassoni, Luca Bertero, Sara Mariani

Publikováno v: British Journal of Cancer

Background: Gene mutations in the RAS family rule out metastatic colorectal carcinomas (mCRCs) from anti-EGFR therapies. Methods: We report a retrospective analysis by Sequenom Massarray and fast COLD-PCR followed by Sanger sequencing on 240 mCRCs. R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd65e6db8a9c2c08c00d81f2b0452e9
https://doi.org/10.1038/bjc.2017.170

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Awareness of mutational artefacts in suboptimal DNA samples: possible risk for therapeutic choices

Autor: Paola Cassoni, Luca Bertero, Sara Mariani, Vittoria Coppola, Caterina Marchiò, Giorgio Maria Saracco, Paola Francia di Celle, Jasna Metovic, Alberto Arezzo

Background Technical biases due to PCR artefacts could represent an insidious obstacle for mutational analysis and precision medicine. Methods The authors report a retrospective analysis by fast COLD-PCR and sequencing of 31 suboptimal tumor DNA samp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deed6428def08c72d5de11dcd8e1b6ca
https://hdl.handle.net/2318/1668404

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