Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Vittoria, Colotta"'
Autor:
Sara Calenda, Daniela Catarzi, Flavia Varano, Erica Vigiani, Rosaria Volpini, Catia Lambertucci, Andrea Spinaci, Letizia Trevisan, Ilenia Grieco, Stephanie Federico, Giampiero Spalluto, Gianluca Novello, Veronica Salmaso, Stefano Moro, Vittoria Colotta
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 468 (2024)
Protein kinase CK1δ (CK1δ) is a serine-threonine/kinase that modulates different physiological processes, including the cell cycle, DNA repair, and apoptosis. CK1δ overexpression, and the consequent hyperphosphorylation of specific proteins, can l
Externí odkaz:
https://doaj.org/article/b944e2eddc9841ab94df3e8bb3daf1fb
Autor:
Martina Venturini, Federica Cherchi, Clara Santalmasi, Lucia Frulloni, Ilaria Dettori, Daniela Catarzi, Felicita Pedata, Vittoria Colotta, Flavia Varano, Elisabetta Coppi, Anna Maria Pugliese
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 894 (2023)
In recent years, the use of multi-target compounds has become an increasingly pursued strategy to treat complex pathologies, including cerebral ischemia. Adenosine and its receptors (A1AR, A2AAR, A2BAR, A3AR) are known to play a crucial role in synap
Externí odkaz:
https://doaj.org/article/967ca781ef344086a54e640f6929530b
Autor:
Andrea Spinaci, Michela Buccioni, Daniela Catarzi, Chang Cui, Vittoria Colotta, Diego Dal Ben, Eleonora Cescon, Beatrice Francucci, Ilenia Grieco, Catia Lambertucci, Gabriella Marucci, Davide Bassani, Matteo Pavan, Flavia Varano, Stephanie Federico, Giampiero Spalluto, Stefano Moro, Rosaria Volpini
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 167 (2023)
Based on a screening of a chemical library of A2A adenosine receptor (AR) antagonists, a series of di- and tri-substituted adenine derivatives were synthesized and tested for their ability to inhibit the activity of the enzyme casein kinase 1 delta (
Externí odkaz:
https://doaj.org/article/1f850dd815cb47c18c31a8c7ecb2492f
Autor:
Daniela Catarzi, Flavia Varano, Erica Vigiani, Sara Calenda, Fabrizio Melani, Katia Varani, Fabrizio Vincenzi, Silvia Pasquini, Natascia Mennini, Giulia Nerli, Diego Dal Ben, Rosaria Volpini, Vittoria Colotta
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 478 (2022)
A new set of amino-3,5-dicyanopyridines was synthesized and biologically evaluated at the adenosine receptors (ARs). This chemical class is particularly versatile, as small structural modifications can influence not only affinity and selectivity, but
Externí odkaz:
https://doaj.org/article/2d4d17b2c4234db89836b4d36ba4b954
Autor:
Flavia Varano, Daniela Catarzi, Erica Vigiani, Diego Dal Ben, Michela Buccioni, Gabriella Marucci, Lorenzo Di Cesare Mannelli, Elena Lucarini, Carla Ghelardini, Rosaria Volpini, Vittoria Colotta
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 657 (2021)
New compounds with a 7-amino-2-arylmethyl-thiazolo[5,4-d]pyrimidine structure were synthesized and evaluated in vitro for their affinity and/or potency at the human (h) A1, hA2A, hA2B, and hA3 adenosine receptors (ARs). Several compounds (5, 8–10,
Externí odkaz:
https://doaj.org/article/321d30349f8c4c519878eee1561c7b9f
Autor:
Lucia Squarcialupi, Marco Betti, Daniela Catarzi, Flavia Varano, Matteo Falsini, Annalisa Ravani, Silvia Pasquini, Fabrizio Vincenzi, Veronica Salmaso, Mattia Sturlese, Katia Varani, Stefano Moro, Vittoria Colotta
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 248-263 (2017)
New 7-amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives, substituted at the 5-position with aryl(alkyl)amino- and 4-substituted-piperazin-1-yl- moieties, were synthesized with the aim of targeting human (h) adenosine A1 and/or A2A receptor subtypes
Externí odkaz:
https://doaj.org/article/3becb9391fc64475b2620dd24841af0a
Publikováno v:
Pharmaceuticals, Vol 14, Iss 2, p 140 (2021)
The idea of promoting this Special Issue arises from the desire to witness the multidisciplinary efforts that are currently in progress to provide new insights into the pathophysiological role of adenosine [...]
Externí odkaz:
https://doaj.org/article/40e3c312806748c3b59639cf2a43ca5f
Autor:
Andrea, Spinaci, Michela, Buccioni, Daniela, Catarzi, Chang, Cui, Vittoria, Colotta, Diego Dal Ben, Eleonora, Cescon, Beatrice, Francucci, Ilenia, Grieco, Catia, Lambertucci, Gabriella, Marucci, Bassani, Davide, Pavan, Matteo, Flavia, Varano, Stephanie, Federico, Giampiero, Spalluto, Moro, Stefano, Rosaria, Volpini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3657::04f30cf1fb13eb226d665596b83a9386
https://hdl.handle.net/11577/3469385
https://hdl.handle.net/11577/3469385
Autor:
Flavia Varano, Daniela Catarzi, Erica Vigiani, Fabrizio Vincenzi, Silvia Pasquini, Katia Varani, Vittoria Colotta
Publikováno v:
Pharmaceuticals, Vol 13, Iss 8, p 161 (2020)
The therapeutic use of A2A adenosine receptor (AR) antagonists for the treatment of neurodegenerative disorders, such as Parkinson and Alzheimer diseases, is a very promising approach. Moreover, the potential therapeutic role of A2A AR antagonists to
Externí odkaz:
https://doaj.org/article/2d853d2dd4dc47f2b14d9c0af2df4f1c