Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever.

Autor: Kotliar D; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA. dkotliar@mgb.org.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA. dkotliar@mgb.org.; Department of Internal Medicine, Brigham and Women's Hospital, Boston, MA, USA. dkotliar@mgb.org., Raju S; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Tabrizi S; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Odia I; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Goba A; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Momoh M; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone.; Eastern Polytechnic College, Kenema, Sierra Leone., Sandi JD; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Nair P; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Phelan E; Prospr at Work Inc., Berlin, Germany., Tariyal R; NextGen Jane, Inc., Oakland, CA, USA., Eromon PE; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria.; African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Nigeria., Mehta S; Department of Critical Care Medicine, University of Maryland Medical Center, Baltimore, MA, USA., Robles-Sikisaka R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Siddle KJ; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Stremlau M; Equator Labs Incorporated, Washington, DC, USA., Jalloh S; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Gire SK; NextGen Jane, Inc., Oakland, CA, USA., Winnicki S; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Chak B; Biological Sciences Division, University of Chicago, Chicago, IL, USA., Schaffner SF; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA., Pauthner M; Vir Biotechnology, San Francisco, CA, USA., Karlsson EK; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.; Program in Molecular Medicine, UMass Chan Medical School, Worcester, MA, USA., Chapin SR; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Kennedy SG; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Branco LM; Zalgen Labs, Frederick, MD, USA., Kanneh L; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone., Vitti JJ; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Broodie N; New York-Presbyterian Hospital-Columbia and Cornell, New York, NY, USA., Gladden-Young A; Molecular Microbiology, Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA., Omoniwa O; Malaria Consortium, Abuja, Nigeria., Jiang PP; Google Medical Brain, Mountain View, CA, USA., Yozwiak N; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA., Heuklom S; San Francisco Community Health Center, San Francisco, CA, USA., Moses LM; Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Akpede GO; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria.; Department of Medicine, Ambrose Alli University, Ekpoma, Nigeria., Asogun DA; Department of Community Medicine, Ambrose Alli University, Ekpoma, Nigeria., Rubins K; National Aeronautics and Space Administration, Houston, TX, USA., Kales S; The Jackson Laboratory, Bar Harbor, ME, USA., Happi AN; African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Nigeria., Iruolagbe CO; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Dic-Ijiewere M; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Iraoyah K; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Osazuwa OO; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Okonkwo AK; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Kunz S; Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland., McCormick JB; UTHealth Houston School of Public Health, Brownsville Campus, Brownsville, TX, USA., Khan SH; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Honko AN; Boston University School of Medicine, Boston, MA, USA., Lander ES; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA., Oldstone MBA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Hensley L; National Institutes of Health Integrated Research Facility, Frederick, MA, USA., Folarin OA; African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Nigeria.; Department of Biological Sciences, Redeemer's University, Ede, Nigeria., Okogbenin SA; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Günther S; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany., Ollila HM; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Tewhey R; The Jackson Laboratory, Bar Harbor, ME, USA., Okokhere PO; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria.; Department of Medicine, Ambrose Alli University, Ekpoma, Nigeria.; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Schieffelin JS; Section of Infectious Disease, Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA., Andersen KG; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Reilly SK; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., Grant DS; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone.; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone., Garry RF; Tulane University School of Medicine, New Orleans, LA, USA., Barnes KG; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi.; Department of Vector Biology and Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK., Happi CT; African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Nigeria. happic@run.edu.ng.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA. happic@run.edu.ng.; Department of Biological Sciences, Redeemer's University, Ede, Nigeria. happic@run.edu.ng., Sabeti PC; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA. pardis@broadinstitute.org.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. pardis@broadinstitute.org.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA. pardis@broadinstitute.org.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA. pardis@broadinstitute.org.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. pardis@broadinstitute.org.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA. pardis@broadinstitute.org.

Publikováno v: Nature microbiology [Nat Microbiol] 2024 Mar; Vol. 9 (3), pp. 751-762. Date of Electronic Publication: 2024 Feb 07.

Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus.

Autor: Andersen KG; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA; The Scripps Research Institute, Scripps Translational Science Institute, La Jolla, CA 92037, USA. Electronic address: andersen@scripps.edu., Shapiro BJ; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA; Department of Biological Sciences, University of Montréal, Montréal, QC H2V 2S9, Canada., Matranga CB; Broad Institute, Cambridge, MA 02142, USA., Sealfon R; Broad Institute, Cambridge, MA 02142, USA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Lin AE; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA., Moses LM; Tulane Health Sciences Center, Tulane University, New Orleans, LA 70118, USA., Folarin OA; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria; Department of Biological Sciences, College of Natural Sciences, Redeemer's University, Redemption City, Osun State, Nigeria., Goba A; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone., Odia I; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Ehiane PE; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Momoh M; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone; Eastern Polytechnic College, Kenema, Eastern Province, Sierra Leone., England EM; Broad Institute, Cambridge, MA 02142, USA., Winnicki S; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA., Branco LM; Zalgen Labs, Germantown, MD 20876, USA., Gire SK; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA., Phelan E; Broad Institute, Cambridge, MA 02142, USA., Tariyal R; Broad Institute, Cambridge, MA 02142, USA., Tewhey R; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA., Omoniwa O; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Fullah M; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone; Eastern Polytechnic College, Kenema, Eastern Province, Sierra Leone., Fonnie R; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone., Fonnie M; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone., Kanneh L; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone., Jalloh S; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone., Gbakie M; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone., Saffa S; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone., Karbo K; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone., Gladden AD; Broad Institute, Cambridge, MA 02142, USA., Qu J; Broad Institute, Cambridge, MA 02142, USA., Stremlau M; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA., Nekoui M; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA., Finucane HK; Broad Institute, Cambridge, MA 02142, USA., Tabrizi S; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA., Vitti JJ; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Birren B; Broad Institute, Cambridge, MA 02142, USA., Fitzgerald M; Broad Institute, Cambridge, MA 02142, USA., McCowan C; Broad Institute, Cambridge, MA 02142, USA., Ireland A; Broad Institute, Cambridge, MA 02142, USA., Berlin AM; Broad Institute, Cambridge, MA 02142, USA., Bochicchio J; Broad Institute, Cambridge, MA 02142, USA., Tazon-Vega B; Broad Institute, Cambridge, MA 02142, USA., Lennon NJ; Broad Institute, Cambridge, MA 02142, USA., Ryan EM; Broad Institute, Cambridge, MA 02142, USA., Bjornson Z; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94304, USA., Milner DA Jr; Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA., Lukens AK; Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA., Broodie N; College of Medicine, Columbia University, New York, NY 10032, USA., Rowland M; Zalgen Labs, Germantown, MD 20876, USA., Heinrich M; Zalgen Labs, Germantown, MD 20876, USA., Akdag M; Zalgen Labs, Germantown, MD 20876, USA., Schieffelin JS; Tulane Health Sciences Center, Tulane University, New Orleans, LA 70118, USA., Levy D; Tulane Health Sciences Center, Tulane University, New Orleans, LA 70118, USA., Akpan H; Nigerian Federal Ministry of Health, Abuja, Federal Capital Territory, Nigeria., Bausch DG; Tulane Health Sciences Center, Tulane University, New Orleans, LA 70118, USA., Rubins K; The National Aeronautics and Space Administration, Johnson Space Center, Houston, TX 77058, USA., McCormick JB; The University of Texas School of Public Health, Brownsville, TX 77030, USA., Lander ES; Broad Institute, Cambridge, MA 02142, USA., Günther S; Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, 20259 Hamburg, Germany., Hensley L; NIAID Integrated Research Facility, Frederick, MD 21702, USA., Okogbenin S; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Schaffner SF; Broad Institute, Cambridge, MA 02142, USA., Okokhere PO; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Khan SH; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone., Grant DS; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone., Akpede GO; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Asogun DA; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Gnirke A; Broad Institute, Cambridge, MA 02142, USA., Levin JZ; Broad Institute, Cambridge, MA 02142, USA., Happi CT; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria; Department of Biological Sciences, College of Natural Sciences, Redeemer's University, Redemption City, Osun State, Nigeria. Electronic address: happic@run.edu.ng., Garry RF; Tulane Health Sciences Center, Tulane University, New Orleans, LA 70118, USA., Sabeti PC; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA; Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA. Electronic address: psabeti@oeb.harvard.edu.

Publikováno v: Cell [Cell] 2015 Aug 13; Vol. 162 (4), pp. 738-50.

Human evolutionary genomics: ethical and interpretive issues.

Autor: Vitti JJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA. vitti@broadinstitute.org, Cho MK, Tishkoff SA, Sabeti PC

Publikováno v: Trends in genetics : TIG [Trends Genet] 2012 Mar; Vol. 28 (3), pp. 137-45. Date of Electronic Publication: 2012 Jan 20.